Glucose-induced glutathione reduction in mitochondria is involved in the first phase of pancreatic β-cell insulin secretion.

abstract：:The effect of acetaminophen (APAP) dose on the cytochrome P450s responsible for its bioactivation was examined in control mice and mice treated with acetone to induce CYP2E1, or beta-napthaflavone to induce CYP1A2. In non-induced mice, 150 mg/kg APAP caused minimal hepatotoxicity and loss of CYP2E1- but not CYP1A2-dep...

journal_title：Biochemical and biophysical research communications

authors： Snawder JE,Roe AL,Benson RW,Roberts DW

更新日期：1994-08-30 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis and its activation during T cell receptor stimulation has recently been reported. In this study, we examined the role of AMPK in interleukin (IL)-2 production in T cells. Inhibition of AMPK by compound C, a specific inhibitor of AMPK or small...

journal_title：Biochemical and biophysical research communications

authors： Jhun BS,Lee JY,Oh YT,Lee JH,Choe W,Baik HH,Kim SS,Yoon KS,Ha J,Kang I

更新日期：2006-12-29 00:00:00

abstract：:Insulin-like growth factor 1 receptor (IGF1R) is expressed in many types of solid tumors including non-small cell lung cancer (NSCLC), and enhanced activation of IGF1R is thought to reflect cancer progression. Epithelial-mesenchymal transition (EMT) has been established as one of the mechanisms responsible for cancer ...

journal_title：Biochemical and biophysical research communications

authors： Nurwidya F,Takahashi F,Kobayashi I,Murakami A,Kato M,Minakata K,Nara T,Hashimoto M,Yagishita S,Baskoro H,Hidayat M,Shimada N,Takahashi K

更新日期：2014-12-12 00:00:00

abstract：:The crude extracts from Sphingomonas paucimobilus containing 2-hydroxy fatty acid-rich sphingolipids were found to oxidize [1-14C]-myristate to 2-hydroxymyristate in the presence of NADH. The myristate-oxidation activity was partially purified about 290-fold from the cell-free extracts by ammonium sulfate fractionatio...

journal_title：Biochemical and biophysical research communications

authors： Matsunaga I,Kusunose E,Yano I,Ichihara K

更新日期：1994-06-30 00:00:00

abstract：:The cyclic pyrimidine nucleotide, cCMP, is an endogenous substance in mammalian cells but little is known on its functional role. We studied the effects of cCMP, its cell-permeant analogue, N4,2'-O-dibutyryl cytidine 3':5'-cyclic monophosphate (Bt2cCMP), and of butyrate on superoxide (O2-) formation and cytosolic Ca2+...

journal_title：Biochemical and biophysical research communications

authors： Ervens J,Seifert R

更新日期：1991-01-15 00:00:00

abstract：:The phosphonodifluoromethyl phenylalanine (F2Pmp) is superior to phosphonomethyl phenylalanine (Pmp) as a non-hydrolyzable phosphotyrosine (pTyr) mimetic. The difluoromethyl moiety increases the inhibitory potency of a F2Pmp-containing peptide over a Pmp-containing counterpart by 1000-fold toward the protein tyrosine ...

journal_title：Biochemical and biophysical research communications

authors： Chen L,Wu L,Otaka A,Smyth MS,Roller PP,Burke TR Jr,den Hertog J,Zhang ZY

更新日期：1995-11-22 00:00:00

abstract：:12-O-tetradecanoyl phorbol 13-acetate (TPA) and 1,2-dioctanoyl-sn-glycerol (diC8) activate protein kinase C (PKC) in transformed fetal bovine aortic endothelial GM 7373 cells. Both molecules cause a similar increase in membrane-associated PKC activity and in the phosphorylation of a PKC-specific endogenous 87-kDa subs...

journal_title：Biochemical and biophysical research communications

authors： Maier JA,Presta M,Ragnotti G

更新日期：1989-04-28 00:00:00

abstract：:Voltage-gated sodium channels (Na(v)) consist of a pore-forming alpha subunit (Na(v)alpha) associated with beta regulatory subunits (Na(v)beta). Adult skeletal myocytes primarily express Na(v)1.4 channels. We found, however, using neonatal L6E9 myocytes, that myofibers acquire a Na(v)1.5-cardiac-like phenotype efficie...

journal_title：Biochemical and biophysical research communications

authors： David M,Martínez-Mármol R,Gonzalez T,Felipe A,Valenzuela C

更新日期：2008-04-11 00:00:00

abstract：:Mutations in mitochondrial DNA (mtDNA) are associated with diverse pathological states in humans, notably sensorineural deafness. In humans, mtDNA4977 deletion, known as common deletion, is thought to play a critical role in presbyacusis. A similar mtDNA deletion occurs in the naturally aging rats is mtDNA4834 deletio...

journal_title：Biochemical and biophysical research communications

authors： Kong WJ,Hu YJ,Wang Q,Wang Y,Han YC,Cheng HM,Kong W,Guan MX

更新日期：2006-05-26 00:00:00

abstract：:microRNA-222 (miR-222) has been shown to initiate the activation of hepatic stellate cells, which plays an important role in the pathogenesis of liver fibrosis. The aim of our study was to evaluate the role of miR-22 in a mouse model of biliary atresia (BA) induced by Rhesus Rotavirus (RRV) infection. New-born Balb/c ...

journal_title：Biochemical and biophysical research communications

authors： Shen WJ,Dong R,Chen G,Zheng S

更新日期：2014-03-28 00:00:00

abstract：:An inhibitor against the egg beta-D-N-acetylglucosaminidase (GlcNAcase) was purified from the vitelline coat of eggs of the ascidian, Halocynthia roretzi. The purified inhibitor gave a single band with an apparent molecular mass of 70 kDa on SDS-PAGE under non-reducing conditions. The GlcNAcase inhibitor potently inhi...

journal_title：Biochemical and biophysical research communications

authors： Matsuura K,Sawada H,Yokosawa H

更新日期：1995-08-04 00:00:00

abstract：:CD1d is a specific ligand for the invariant Valpha24Vbeta11-natural killer T (iNKT) cells that play an important role in placental development during early human pregnancy. The localization and regulation of placental CD1d expression remain unclear. Immunohistochemistry of human early gestational placentas revealed CD...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto J,Kawana K,Nagamatsu T,Schust DJ,Fujii T,Sato H,Hyodo H,Yasugi T,Kozuma S,Taketani Y

更新日期：2008-06-27 00:00:00

abstract：:We have previously reported that salmosin, a novel disintegrin, was isolated from Korean snake (Agkistrodon halys brevicaudus) venom and significantly inhibited solid tumor growth in mice by perturbation of tumor-specific angiogenesis via blocking alphavbeta3 integrin expressed on vascular endothelial cells. In this s...

journal_title：Biochemical and biophysical research communications

authors： Kang IC,Kim DS,Jang Y,Chung KH

更新日期：2000-08-18 00:00:00

abstract：:An antifungal protein that inhibits the growth of filamentous fungal pathogens was isolated from Chinese cabbage (Brassica campestris L. ssp. pekinensis) by affinity chromatography on Affi-gel blue gel and ion exchange chromatography on CM-Sepharose. The N-terminal amino acid sequence of the protein was highly homolog...

journal_title：Biochemical and biophysical research communications

authors： Lee JR,Park SC,Kim JY,Lee SS,Park Y,Cheong GW,Hahm KS,Lee SY

更新日期：2007-02-16 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disorder characterised by extracellular accumulation of the Abeta peptide, derived from the amyloid precursor protein (APP). The function of APP as a cell surface receptor was examined by ligand-mimicking using an antibody against the APP extracellular domain. Alterations in ...

journal_title：Biochemical and biophysical research communications

authors： Nilsson T,Malkiewicz K,Gabrielsson M,Folkesson R,Winblad B,Benedikz E

更新日期：2006-03-24 00:00:00

abstract：:Although it is widely accepted that insulin stimulates leptin secretion, a dual action was observed using a validated in vitro system, i.e., an early (less than 48 h) inhibitory action, followed later (48-96 h) by a clear-cut stimulation. While the inhibitory phase was observed at every glucose concentration tested (f...

journal_title：Biochemical and biophysical research communications

authors： Casabiell X,Piñeiro V,De la Cruz LF,Gualillo O,Folgar L,Diéguez C,Casanueva FF

更新日期：2000-09-24 00:00:00

abstract：:The P-type ATPases affected in Menkes and Wilson diseases, ATP7A and ATP7B, respectively, are key copper transporters that regulate copper homeostasis. The N termini of these proteins are critical in regulating their function and activity, and contain six copper-binding motifs MxCxxC. In this study, we describe the id...

journal_title：Biochemical and biophysical research communications

authors： Lim CM,Cater MA,Mercer JF,La Fontaine S

更新日期：2006-09-22 00:00:00

abstract：:Therapeutic effects of combination of angiogenic growth factors for the treatment of ischemia after myocardial infarction are largely unknown. Plasmids expressing basic fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF-BB) or their combination with a 1:1 mass ratio were injected into hearts with 7-...

journal_title：Biochemical and biophysical research communications

authors： Hao X,Månsson-Broberg A,Gustafsson T,Grinnemo KH,Blomberg P,Siddiqui AJ,Wärdell E,Sylvén C

更新日期：2004-03-19 00:00:00

abstract：:IL-10 producing B (B10) cells, a subset of regulatory B (Breg) cells, produce IL-10 and play immunosuppressive roles in antitumor immunity. B10 cells are associated with enhanced tumor-aggressiveness and a poorer prognosis. To specifically inhibit the IL-10 secreted by B cells, we constructed the recombinant plasmid p...

journal_title：Biochemical and biophysical research communications

authors： Zhao R,Liu M,Li X,Chen H,Deng J,Huang C,Zhang XL,Pan Q

更新日期：2018-12-02 00:00:00

abstract：:Hepatic glucokinase is induced by insulin and repressed by glucagon. The effects of epidermal growth factor (EGF) on glucokinase expression were investigated in rat hepatocytes. EGF does not affect the decline in glucokinase activity in hepatocytes cultured for 48h in the absence of insulin, but it counteracts the inc...

journal_title：Biochemical and biophysical research communications

authors： Beresford GW,Agius L

更新日期：1994-06-15 00:00:00

abstract：:The two zinc fingers of the DNA binding domain of the human retinoic acid receptor-beta were labelled with 113Cd. Two- and three-dimensional heteronuclear nuclear magnetic resonance (NMR) experiments show that the first eight conserved cysteine residues coordinate the two zinc ions tetrahedrally. The ninth conserved c...

journal_title：Biochemical and biophysical research communications

authors： Knegtel RM,Boelens R,Ganadu ML,George AV,van der Saag PT,Kaptein R

更新日期：1993-04-30 00:00:00

abstract：:We report the cloning and characterization of both the cDNA (tufA) and genomic clones encoding for a chloroplast translation elongation factor (EF-Tu) from pea. The analysis of the deduced amino acids of the cDNA clone reveals the presence of putative transit peptide sequence and four GTP binding domains and two EF-Tu...

journal_title：Biochemical and biophysical research communications

authors： Singh BN,Mishra RN,Agarwal PK,Goswami M,Nair S,Sopory SK,Reddy MK

更新日期：2004-07-23 00:00:00

abstract：:The tumor suppressor p53, a 393-amino acid transcription factor with four domains, induces cell cycle arrest, senescence, and apoptosis in response to diverse stress. Tetramer formation is critical for the function of p53. The tetramerization domain permits the tetramerization of p53, where bundled four DNA-binding do...

journal_title：Biochemical and biophysical research communications

authors： Inobe T,Nozaki M,Nukina N

更新日期：2015-11-13 00:00:00

abstract：:Insect midgut peritrophic membrane (PM) is a functional structure that protects insects against chemical damage and microorganism infection. The essential component in PM is chitin and its synthesis is catalyzed by Class B chitin synthase (CHSB), which plays a unique role in chitin-containing organisms and thus repres...

journal_title：Biochemical and biophysical research communications

authors： Qu M,Liu T,Yang J,Yang Q

更新日期：2011-01-07 00:00:00

abstract：:The pathway employed for pentachlorophenol (PCP) degradation by an aerobic, chlorophenol-utilizing Flavobacterium sp. was initiated by conversion of PCP to tetrachloro-p-hydroquinone (TCH). 18O labelling experiments demonstrated that the first dechlorination, where a hydroxyl replaced the chlorine at PCP ring position...

journal_title：Biochemical and biophysical research communications

authors： Steiert JG,Crawford RL

更新日期：1986-12-15 00:00:00

abstract：:Pancreatic elastase has been implicated in the pathophysiology of severe acute pancreatitis, characterized by systemic inflammatory response, distant organ failure, and high mortality. Here we show that pancreatic elastase activates transcription factors NF-kappaB, AP-1, and NFAT in human myeloid cells (U-937 and THP-...

journal_title：Biochemical and biophysical research communications

authors： Hietaranta A,Mustonen H,Puolakkainen P,Haapiainen R,Kemppainen E

更新日期：2004-10-08 00:00:00

abstract：:Caspase-3 and caspase-7 are structurally closely related and demonstrate overlapping substrate specificity. However, during apoptosis, they are differentially regulated and show distinct subcellular localizations, implying the presence of specific substrates. In this study, to identify caspase-7 substrates, we treated...

journal_title：Biochemical and biophysical research communications

authors： Jang M,Park BC,Lee AY,Na KS,Kang S,Bae KH,Myung PK,Chung BC,Cho S,Lee DH,Park SG

更新日期：2007-11-16 00:00:00

abstract：:The Fru-6-P/Fru-2,6-P2 exchange reaction of rat liver 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase was almost entirely dependent on the presence of Pi. This exchange was not due to a reversal of the bisphosphatase nor to trace amounts of adenine nucleotide in the enzyme. Exchange activity was maximal at pH 7, ...

journal_title：Biochemical and biophysical research communications

authors： El-Maghrabi MR,Pate TM,Pilkis SJ

更新日期：1984-09-17 00:00:00

abstract：:In this study, acetosyringone was identified as one of the major extracellular phenolics in tobacco suspension cells and was shown to have bioactive properties that influence early events in plant-bacterial pathogenesis. In our model system, tobacco cell suspensions treated with bacterial isolate Pseudomonas syringae ...

journal_title：Biochemical and biophysical research communications

authors： Baker CJ,Mock NM,Whitaker BD,Roberts DP,Rice CP,Deahl KL,Aver'yanov AA

更新日期：2005-03-04 00:00:00

abstract：:Apoaequorin was targeted to the cytosol, nucleus, and endoplasmic reticulum of HeLa cells in order to determine the effect of Ca(2+) release from the ER on protein degradation. In resting cells apoaequorin had a rapid half-life (ca. 20-30 min) in the cytosol or nucleus, but was relatively stable for up to 24 h in the ...

journal_title：Biochemical and biophysical research communications

authors： Jeffery J,Kendall JM,Campbell AK

更新日期：2000-02-24 00:00:00