Abstract:
:IGF-I, when added to TSH-primed FRTL-5 cells, induces a long lasting Ca2+ influx and then DNA synthesis. Ca2+ channel agonist, BAYK 8644, is capable to mimic these effects on cell proliferation. We studied the effect of genistein, a specific tyrosine kinase inhibitor, on BAY K8644- or IGF-I- induced cell cycle progression in FRTL-5 cells. Genistein inhibited DNA synthesis induced by BAY K8644 and by IGF-I. In contrast, Ca2+ influx stimulated by BAY K8644 was not inhibited. These data demonstrate that the signal transduction pathway induced by BAY K8644 or IGF-I may possibly involve genistein-sensitive process at the downstream step of Ca2+ entry.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Takano T,Takada K,Tada H,Nishiyama S,Amino Ndoi
10.1006/bbrc.1993.1120subject
Has Abstractpub_date
1993-02-15 00:00:00pages
801-7issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(83)71120-4journal_volume
190pub_type
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pub_type: 杂志文章
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