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Expression of enhancer binding factors associated with various cell types of lung cancer.

Abstract：

:Differential expression of nuclear factors binding specifically to AP-1, AP-2, AP-3, and NF-I/CTF enhancer elements was found in the various cell types of human lung carcinoma cells. Adenocarcinoma and squamous carcinoma cells seemed to express higher levels of these factors than large-cell carcinoma and small-cell carcinoma cells. Among small-cell carcinoma cells, variant small-cell carcinoma cells which presumably are closer than classical small-cell carcinoma cells to non-small-cell carcinoma cells in terms of differentiation characteristics also expressed higher levels of these factors. Furthermore, nuclear extracts from the various cell types of carcinoma cells were found to produce different patterns of electrophoretic mobility shift even with the same enhancer element, suggesting the presence of multiple species of specific enhancer-binding activities in these cells. Thus, these enhancer elements may be used as probes for cell-type specificity in the study of differentiation of lung carcinomas.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wong YC,Bernal SD

doi

10.1016/s0006-291x(05)81174-x

subject

Has Abstract

pub_date

1991-10-31 00:00:00

pages

1064-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)81174-X

journal_volume

180

pub_type

杂志文章

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