当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase.

Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase.

Abstract：

:The gene encoding the human puromycin-sensitive aminopeptidase (PSA) has been cloned and characterized. The human PSA gene is composed of 23 exons and 22 introns and spans approximately 40 kb of chromosome 17 at the interval 17q12-21. An analysis of the 5' end of the human PSA transcript reveals that the translational start site corresponds to nt 210 of the human PSA cDNA, as suggested by RT-PCR, 5' RACE, and computer analysis of expressed sequence tags. A comparison of the exon/exon boundaries of the human PSA gene with those of the human aminopeptidase N (APN) gene shows little conservation, suggesting that the two genes, which are closely related in protein sequence, diverged early during evolution.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Thompson MW,Tobler A,Fontana A,Hersh LB

doi

10.1006/bbrc.1999.0604

subject

Has Abstract

pub_date

1999-05-10 00:00:00

pages

234-40

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(99)90604-6

journal_volume

258

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Identification of a rapidly dephosphorylating 95-kDa protein as elongation factor 2 during 8-Br-cAMP treatment of N1E115 neuroblastoma cells.

    abstract：:Treatment of 8-Br-cAMP promotes neurite outgrowth and neuronal differentiation in N1E115 mouse neuroblastoma cells. Prior or simultaneous treatment of PMA blocks 8-Br-cAMP-mediated neurite outgrowth. Phosphorylation of cellular proteins during these treatments was examined in a permeabilized cell system. While PMA pro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2754

    authors： Li H,Chen HC,Huang FL

    更新日期：1995-12-05 00:00:00

  • The characterization of 5 histidine-serine mutants of human 5-lipoxygenase.

    abstract：:The physical and catalytic properties of 5 histidine-serine mutants of human 5-lipoxygenase (5-LO) have been characterized. The mutants HS363, HS391 and HS400 have activities, pH optima and stabilities similar to those of the wild type enzyme. The iron content of each of these mutants is 0.30-0.53 mol Fe/mol 5-LO whic...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81542-6

    authors： Percival MD,Ouellet M

    更新日期：1992-08-14 00:00:00

  • Upregulation of miR-181a impairs lipid metabolism by targeting PPARα expression in nonalcoholic fatty liver disease.

    abstract：:Recent studies have reported elevated expression of miR-181a in patients with non-alcoholic fatty liver disease (NAFLD), suggesting that it may play an important role in liver lipid metabolism and insulin resistance. We aimed to investigate the effect of miR-181a in lipid metabolism and find new treatments for NAFLD. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.12.061

    authors： Huang R,Duan X,Liu X,Cao H,Wang Y,Fan J,Wang B

    更新日期：2019-01-22 00:00:00

  • Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2).

    abstract：:We previously found that p53 binds to the catalytic subunit of the p34(cdc2)/cyclin B1-kinase. In the present study we analyzed the functional consequences of this interaction. Binding of wild-type p53 to p34(cdc2)/cyclin B1 results in a significant decrease of its histone H1 kinase activity. Binding of p53 to the kin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4792

    authors： Ababneh M,Götz C,Montenarh M

    更新日期：2001-05-04 00:00:00

  • Islet-specific monoamine oxidase A and B expression depends on MafA transcriptional activity and is compromised in type 2 diabetes.

    abstract：:Lack or dysfunction of insulin producing β cells results in the development of type 1 and type 2 diabetes mellitus, respectively. Insulin secretion is controlled by metabolic stimuli (glucose, fatty acids), but also by monoamine neurotransmitters, like dopamine, serotonin, and norepinephrine. Intracellular monoamine l...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.11.002

    authors： Ganic E,Johansson JK,Bennet H,Fex M,Artner I

    更新日期：2015-12-25 00:00:00

  • Induction of apoptosis and endothelin-1 secretion in primary human lung endothelial cells by HIV-1 gp120 proteins.

    abstract：:Pulmonary hypertension associated with human immunodeficiency virus (HIV) infection also involves injury to the lung endothelium. However, the pathogenesis of HIV-induced pulmonary hypertension is not known; we hypothesized that HIV or secreted viral proteins could play a role in vascular injury and the increased freq...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.05.198

    authors： Kanmogne GD,Primeaux C,Grammas P

    更新日期：2005-08-12 00:00:00

  • NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide.

    abstract：:Glucose-dependent insulinotropic polypeptide is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. The glucose-dependent action of GIP on pancreatic beta-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. Use of NMR or X-ray...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.10.033

    authors： Alaña I,Hewage CM,Malthouse JP,Parker JC,Gault VA,O'Harte FP

    更新日期：2004-12-03 00:00:00

  • Generation of an ABCG2(GFPn-puro) transgenic line--a tool to study ABCG2 expression in mice.

    abstract：:The ATP-binding cassette (ABC) transporter 2 (ABCG2) is expressed by stem cells in many organs and in stem cells of solid tumors. These cells are isolated based on the side population (SP) phenotype, a Hoechst 3342 dye efflux property believed to be conferred by ABCG2. Because of the limitations of this approach we ge...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.04.089

    authors： Orford M,Mean R,Lapathitis G,Genethliou N,Panayiotou E,Panayi H,Malas S

    更新日期：2009-06-26 00:00:00

  • Identification of disease-associated proteins by proteomic approach in ankylosing spondylitis.

    abstract：:Ankylosing spondylitis (AS) is a chronic systemic inflammatory disorder of the axial skeleton and shows significant inherited susceptibility. Auto-immune responses have been traditionally considered as a putative pathogenetic event in AS. However, no consistent self-antigen has been identified to responsible for the d...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.03.179

    authors： Liu J,Zhu P,Peng J,Li K,Du J,Gu J,Ou Y

    更新日期：2007-06-01 00:00:00

  • Perfluorooctane sulfonate triggers tight junction "opening" in brain endothelial cells via phosphatidylinositol 3-kinase.

    abstract：:Perfluorooctane sulfonate (PFOS), an environmental pollutant, is widely distributed in humans and wildlife. Accumulation of PFOS in the brain and its neurotoxicity has been reported. Whether PFOS has any effect on the blood-brain barrier (BBB) remains unknown. In this study, human brain microvascular endothelial cells...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.05.128

    authors： Wang X,Li B,Zhao WD,Liu YJ,Shang DS,Fang WG,Chen YH

    更新日期：2011-07-01 00:00:00

  • Engagement of spectrin and actin in capping of FcgammaRII revealed by studies on permeabilized U937 cells.

    abstract：:Plasma membrane receptors can undergo translocation in the plane of plasma membrane after binding of polyvalent ligands. Ligand/receptor clusters, named patches, can collect into a polar cap, presumably due to their association with the submembrane actin-based cytoskeleton. We found that the assembly of Fcgamma recept...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0769

    authors： Kwiatkowska K,Sobota A

    更新日期：1999-06-07 00:00:00

  • R-spondin 2 facilitates differentiation of proliferating chondrocytes into hypertrophic chondrocytes by enhancing Wnt/β-catenin signaling in endochondral ossification.

    abstract：:Endochondral ossification is a crucial process for longitudinal growth of bones. Differentiating chondrocytes in growth cartilage form four sequential zones of proliferation, alignment into column, hypertrophy, and substitution of chondrocytes with osteoblasts. Wnt/β-catenin signaling is essential for differentiation ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.03.089

    authors： Takegami Y,Ohkawara B,Ito M,Masuda A,Nakashima H,Ishiguro N,Ohno K

    更新日期：2016-04-22 00:00:00

  • Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling.

    abstract：:Toll-like receptor 4 (TLR4) activates two distinct signaling pathways inducing production of proinflammatory cytokines or type I interferons (IFNs), respectively. MyD88 and TIRAP/Mal are essential adaptor molecules for the former but not for the latter pathway. In contrast, TRIF/TICAM-1 and TRAM/TICAM-2 are essential ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.01.061

    authors： Tanimura N,Saitoh S,Matsumoto F,Akashi-Takamura S,Miyake K

    更新日期：2008-03-28 00:00:00

  • Metabolic stability of the LHRH antagonist antide to cell-surface peptidases.

    abstract：:The susceptibility to hydrolysis of LHRH and the decapeptide analogue Antide has been compared. The hydrolysis of LHRH by pig kidney brush border membranes is inhibited by phosphoramidon (I50 = 5.6 nM) implicating endopeptidase-24.11 in the initiation of hydrolysis. Under conditions in which LHRH is fully degraded by ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90884-a

    authors： Medeiros Mdos S,Turner AJ,Ljungqvist A,Folkers K

    更新日期：1991-04-15 00:00:00

  • Isolation of distantly related members in a multigene family using the polymerase chain reaction technique.

    abstract：:We have designed a strategy to isolate and identify genes (cDNAs) coding for distantly-related members within a large multigene family. We have used limited protein sequence information data to delineate conserved regions where members of a supergene family are related. Comparison of the nucleotide sequences of such c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91747-g

    authors： Zhao ZY,Joho RH

    更新日期：1990-02-28 00:00:00

  • Nanomolar concentrations of lysophosphatidylcholine recruit monocytes and induce pro-inflammatory cytokine production in macrophages.

    abstract：:Lysophosphatidylcholine (LPC) has been attributed a pro-inflammatory role in atherosclerosis. Cell culture studies have identified stimulation of cytokine expression and chemotaxis by micromolar (muM) concentrations of LPC. In the present study we have investigated if LPC, in similarity with many other lipid mediators...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.03.087

    authors： Olofsson KE,Andersson L,Nilsson J,Björkbacka H

    更新日期：2008-05-30 00:00:00

  • PTH(7-84) inhibits PTH(1-34)-induced 1,25-(OH)2D3 production in murine renal tubules.

    abstract：:To elucidate whether PTH(7-84), a degradation product of PTH(1-84), which inhibits PTH(1-84)-induced bone resorption, also exerts an antagonistic effect on the kidney, we studied the effect of PTH(7-84) on PTH(1-34)-induced production of 1,25-(OH)2D3 in primary cultured murine renal tubules. Neonatal mouse renal tubul...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.02.023

    authors： Nakajima K,Nohtomi K,Sato M,Takano K,Sato K

    更新日期：2009-04-03 00:00:00

  • A newly identified iron-binding protein in rat liver: purification and characterization.

    abstract：:A novel iron-binding protein from rat liver homogenates was purified 1,800-fold with a 5.7% yield, to apparent homogeneity. The molecular weight of the protein was estimated to be 16,000, by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. The purified protein exhibited 0.43 mol of iron bi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81434-2

    authors： Furukawa T,Taketani S,Kohno H,Tokunaga R

    更新日期：1991-11-27 00:00:00

  • In vivo characterisation of the human UCP3 gene minimal promoter in mice tibialis anterior muscles.

    abstract：:Transcriptional mechanisms controlling human UCP3 gene expression in skeletal muscle remain poorly understood. Experiments based on plasmid electrotransfer into tibialis anterior muscle of C57/BL6 male mice were set up in order to functionally analyze the hUCP3 gene promoter. These transfection experiments showed that...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.10.034

    authors： Riquet FB,Rodriguez M,Guigal N,Dromaint S,Naime I,Boutin JA,Galizzi JP

    更新日期：2003-11-21 00:00:00

  • Inhibition by TRPA1 agonists of compound action potentials in the frog sciatic nerve.

    abstract：:Although TRPV1 and TRPM8 agonists (vanilloid capsaicin and menthol, respectively) at high concentrations inhibit action potential conduction, it remains to be unknown whether TRPA1 agonists have a similar action. The present study examined the actions of TRPA1 agonists, cinnamaldehyde (CA) and allyl isothiocyanate (AI...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.02.127

    authors： Matsushita A,Ohtsubo S,Fujita T,Kumamoto E

    更新日期：2013-04-26 00:00:00

  • Turpentine-induced decrease of alpha 1-foetoprotein in the serum of the developing rat: a novel parameter of the inflammatory response.

    abstract：:The acute phase of an inflammation induced in young rats, at various ages between 1 and 21 days after birth, by a single subcutaneous turpentine injection, is accompanied by a 35%-45% decrease of the alpha 1-foetoprotein serum concentrations. This fall is demonstrated with equilibrium dialysis binding methods, evidenc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91032-x

    authors： Savu L,Zouaghi H,Nunez EA

    更新日期：1983-02-10 00:00:00

  • Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages.

    abstract：:There is considerable evidence indicating that intracellular Ca2+ participates as a second messenger in TLR4-dependent signaling. However, how intracellular free Ca2+ concentrations ([Ca2+]i) is increased in response to LPS and how they affect cytokine production are poorly understood. Here we examined the role of tra...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.06.082

    authors： Yamashiro K,Sasano T,Tojo K,Namekata I,Kurokawa J,Sawada N,Suganami T,Kamei Y,Tanaka H,Tajima N,Utsunomiya K,Ogawa Y,Furukawa T

    更新日期：2010-07-23 00:00:00

  • Aggravation of brain infarction through an increase in acrolein production and a decrease in glutathione with aging.

    abstract：:We previously reported that tissue damage during brain infarction was mainly caused by inactivation of proteins by acrolein. This time, it was tested why brain infarction increases in parallel with aging. A mouse model of photochemically induced thrombosis (PIT) was studied using 2, 6, and 12 month-old female C57BL/6 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.03.137

    authors： Uemura T,Watanabe K,Ishibashi M,Saiki R,Kuni K,Nishimura K,Toida T,Kashiwagi K,Igarashi K

    更新日期：2016-04-29 00:00:00

  • Cysteine protease antigens cleave CD123, the α subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion.

    abstract：:Th2 type immune responses are essential for protective immunity against parasites and play crucial roles in allergic disorders. Helminth parasites secrete a variety of proteases for their infectious cycles including for host entry, tissue migration, and suppression of host immune effector cell function. Furthermore, a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.03.022

    authors： Nishikado H,Fujimura T,Taka H,Mineki R,Ogawa H,Okumura K,Takai T

    更新日期：2015-05-01 00:00:00

  • Substance P regulates the function of rabbit cultured osteoclast; increase of intracellular free calcium concentration and enhancement of bone resorption.

    abstract：:The effects of substance P on cultured rabbit osteoclasts were investigated. The intracellular Ca(2+) concentration ([Ca(2+)](i)) which was monitored by the microfluorometric technique using fura-2, in osteoclasts elevated by the addition of substance P (0.3-5 microM). The EC(50) value of substance P was about 200 nM....

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1220

    authors： Mori T,Ogata T,Okumura H,Shibata T,Nakamura Y,Kataoka K

    更新日期：1999-08-27 00:00:00

  • Inhibition of cell death-inducing p53 target 1 through miR-210-3p overexpression attenuates reactive oxygen species and apoptosis in rat adipose-derived stem cells challenged with Angiotensin II.

    abstract：:Hypoxic preconditioning is a well-known strategy to improve the survival and therapeutic potential of stem cells against various challenges including hemodynamic and neurohormonal modulations. However, the mechanism involved in hypoxia-induced benefits on stem cells is still ambiguous. In pathological hypertension, th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.07.052

    authors： Lai CH,Barik P,Hsieh DJ,Day CH,Ho TJ,Chen RJ,Kuo WW,Padma VV,Shibu MA,Huang CY

    更新日期：2020-11-12 00:00:00

  • The role of the N-terminal leucine residue in snake venom cardiotoxin II (Naja naja atra).

    abstract：:The N-terminal leucine residue of snake venom cardiotoxin II (CTX II) (Naja naja atra) was systematically replaced with D-leucine (CTXII-L1-D-L), glycine (CTXII-L1G) or deleted [CTXII-(2-60)] to study the role of leucine residue in CTX II molecule. CTX II, CTXL1-D-L, CTXL1G and CTX(2-60) were produced by chemical synt...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6503

    authors： Wu CY,Chen WC,Ho CL,Chen ST,Wang KT

    更新日期：1997-04-28 00:00:00

  • No evidence for mutations in a putative subunit of the beta-cell ATP-sensitive potassium channel (K-ATP channel) in Japanese NIDDM patients.

    abstract：:The ATP-sensitive K channel (K-ATP channel) in pancreatic beta cells is believed to play a crucial role in glucose-stimulated insulin release. We investigated whether defects in the recently cloned gene for a putative subunit of this channel (KATP-2) could be a cause of diabetes in Japanese patients. The coding region...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1915

    authors： Yasuda K,Sakura H,Mori Y,Iwamoto K,Shimokawa K,Kadowaki H,Hagura R,Akanuma Y,Adelman JP,Yazaki Y

    更新日期：1995-06-26 00:00:00

  • Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.

    abstract：:A primary cellular target of the clinical nitrogenous bisphosphonates is the isoprenoid biosynthetic pathway. Specifically these drugs inhibit the enzyme farnesyl pyrophosphate synthase and deplete cells of larger isoprenoids. Inhibition of this enzyme results in impaired processing of both farnesylated and geranylger...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.094

    authors： Wiemer AJ,Tong H,Swanson KM,Hohl RJ

    更新日期：2007-02-23 00:00:00

  • Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors.

    abstract：:We have cloned the cDNA encoding human PICK1 (protein interacting with C kinase 1), a PDZ domain-containing protein of 415 amino acids, and also identified the Drosophila homologue by search of the databank. Northern blot analysis shows a single mRNA of about 2.0 kb ubiquitously expressed in human tissues. Although PI...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1932

    authors： Takeya R,Takeshige K,Sumimoto H

    更新日期：2000-01-07 00:00:00