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Aggravation of brain infarction through an increase in acrolein production and a decrease in glutathione with aging.

Abstract：

:We previously reported that tissue damage during brain infarction was mainly caused by inactivation of proteins by acrolein. This time, it was tested why brain infarction increases in parallel with aging. A mouse model of photochemically induced thrombosis (PIT) was studied using 2, 6, and 12 month-old female C57BL/6 mice. The size of brain infarction in the mouse PIT model increased with aging. The volume of brain infarction in 12 month-old mice was approximately 2-fold larger than that in 2 month-old mice. The larger brain infarction in 12 month-old mice was due to an increase in acrolein based on an increase in the activity of spermine oxidase, together with a decrease in glutathione (GSH), a major acrolein-detoxifying compound in cells, based on the decrease in one of the subunits of glutathione biosynthesizing enzymes, γ-glutamylcysteine ligase modifier subunit, with aging. The results indicate that aggravation of brain infarction with aging was mainly due to the increase in acrolein production and the decrease in GSH in brain.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Uemura T,Watanabe K,Ishibashi M,Saiki R,Kuni K,Nishimura K,Toida T,Kashiwagi K,Igarashi K

doi

10.1016/j.bbrc.2016.03.137

subject

Has Abstract

pub_date

2016-04-29 00:00:00

pages

630-5

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(16)30449-1

journal_volume

473

pub_type

杂志文章

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