Getting mitochondria to center stage.

abstract：:Since conventional chemotherapy (gemcitabine and cisplatin) has marginal survival benefit in patients with advanced cholangiocarcinoma (CCA), an effective targeted therapeutic agent is urgently required. Activation of the PI3K/Akt/mTOR signaling pathway is frequently observed in CCA, and thus, PI3K and mTOR are promis...

journal_title：Biochemical and biophysical research communications

authors： Jang DK,Lee YG,Chan Chae Y,Lee JK,Paik WH,Lee SH,Kim YT,Ryu JK

更新日期：2020-09-03 00:00:00

abstract：:Depression is a common psychiatric disorder that affects millions of people around the world, however, little is known about the pathophysiology of depression and the therapeutic strategy for anti-depression. In this study, we investigated the role of irisin, a regulator of energy metabolism, in the modulation of depr...

journal_title：Biochemical and biophysical research communications

authors： Wang S,Pan J

更新日期：2016-05-20 00:00:00

abstract：:Identifying Mycobacterium tuberculosis membrane proteins involved in binding to and invasion of host cells is important in designing subunit-based anti-tuberculosis vaccines. The Rv2969c gene sequence was identified by PCR in M. tuberculosis complex strains, being transcribed in M. tuberculosis H37Rv, M. tuberculosis ...

journal_title：Biochemical and biophysical research communications

authors： Patarroyo MA,Plaza DF,Ocampo M,Curtidor H,Forero M,Rodriguez LE,Patarroyo ME

更新日期：2008-08-08 00:00:00

abstract：:Based on molecular modelling study, we propose that the reaction between L-aspartate an carbamoylphosphate, catalyzed by E. coli aspartate carbamoyltransferase, may proceed via a tetrahedral intermediate and that the breakdown of the intermediate is facilitated by an intramolecular proton transfer between the amino gr...

journal_title：Biochemical and biophysical research communications

authors： Gouaux JE,Krause KL,Lipscomb WN

更新日期：1987-02-13 00:00:00

abstract：:The trophoblast-like choriocarcinoma cell line BeWo expresses a receptor for vascular endothelial growth factor (VEGF) and proliferates in response to VEGF. Nitric oxide (NO) seems to play a key role in the VEGF-induced proliferation of endothelial cells but the NO mechanistic regulation of VEGF-stimulated trophoblast...

journal_title：Biochemical and biophysical research communications

authors： Cha MS,Lee MJ,Je GH,Kwak JY

更新日期：2001-04-13 00:00:00

abstract：:The 65 kDa C8-binding protein or homologous restriction factor (C8bp/HRF) protects cells from complement (C)-mediated lysis by binding to C8 and abrogating lytic channel formation. Human C8bp/HRF is shown here to be immunologically related to human C8 and C9 and to murine lymphocyte poreforming protein (PFP, perforin)...

journal_title：Biochemical and biophysical research communications

authors： Young JD,Rosse WF,Hasselkus-Light CS

更新日期：1990-01-30 00:00:00

abstract：:It is widely considered that it is not appropriate to treat beta-pairs in isolation, since other secondary structural models (such as helices, coils), protein topology and protein tertiary structures would limit beta-strand pairing. However, to understand the underlying mechanisms of beta-sheet formation, studies ough...

journal_title：Biochemical and biophysical research communications

authors： Zhang N,Ruan J,Duan G,Gao S,Zhang T

更新日期：2009-08-28 00:00:00

abstract：:Free methionine-R-sulfoxide reductase (fRMsr) is a new type of methionine sulfoxide reductase that catalyzes the reduction of free methionine-R-sulfoxide to methionine. This enzyme cannot reduce oxidized methionine residues in proteins. While three Cys residues, Cys-91, Cys-101 and Cys-125, have been demonstrated to b...

journal_title：Biochemical and biophysical research communications

authors： Kwak GH,Kim MJ,Kim HY

更新日期：2010-05-07 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPAR gamma) belongs to a nuclear receptor super family that functions as a master regulator of adipocyte differentiation. PPAR gamma binds its DNA response element together with a partner, retinoid X receptor (RXR), in fat cells. Five RXR ligands (HX600, HX630, DA022, ...

journal_title：Biochemical and biophysical research communications

authors： Sato M,Yajima Y,Kawashima S,Tanaka K,Kagechika H

更新日期：2001-01-26 00:00:00

abstract：:Activation of protein kinase C has been shown to be involved in the activation pathway of many cell types. Recently, a number of investigations have suggested that protein kinase C plays an essential role in T lymphocyte activation. The recent synthesis of the protein kinase inhibitors, H-7 and HA1004, have now made p...

journal_title：Biochemical and biophysical research communications

authors： Clark RB,Love JT Jr,Sgroi D,Lingenheld EG,Sha'afi RI

更新日期：1987-06-15 00:00:00

abstract：:Despite the fact that the phosphorylation-mediated regulation of L-type Ca channels is viewed as a model of ion channel regulation, much remains to be learned about the protein phosphorylation and dephosphorylation reactions that underlie the regulation of the channels. The channel isoform most well studied biochemica...

journal_title：Biochemical and biophysical research communications

authors： Zhao XL,Gutierrez LM,Chang CF,Hosey MM

更新日期：1994-01-14 00:00:00

abstract：:We have isolated and sequenced a cDNA encoding the follicle stimulating hormone (FSH) receptor. The deduced amino acid sequence (678 residues) containing seven putative transmembrane segments which displays sequence similarity to G protein-coupled receptors. The receptor consists of 359 residue extracellular domain wh...

journal_title：Biochemical and biophysical research communications

authors： Minegishi T,Nakamura K,Takakura Y,Ibuki Y,Igarashi M,Minegish T corrected to Minegishi T

更新日期：1991-03-29 00:00:00

abstract：:Cytokine induced pancreatic beta-cell destruction seen in Type 1 diabetes and islet graft rejection involves multiple intracellular signaling pathways that directly or indirectly lead to inflammatory damage or programmed cell death. IL-1beta has been shown to stimulate the 12-lipoxygenase pathway product 12-HETE, in R...

journal_title：Biochemical and biophysical research communications

authors： Bleich D,Chen S,Wen Y,Nadler JL

更新日期：1997-01-13 00:00:00

abstract：:Thymoquinone (TQ), a component derived from the bioactive constituent of black seed (Nigella sativa), has been shown to exert biological activity on various types of human cancers. However, there are few studies addressing its effects on gastric cancer. Here, we present the first report describing the chemosensitizing...

journal_title：Biochemical and biophysical research communications

authors： Lei X,Lv X,Liu M,Yang Z,Ji M,Guo X,Dong W

更新日期：2012-01-13 00:00:00

abstract：:The DNA-binding activity of a 42-kDa phosphoprotein from salivary gland cells and cultured epithelial cells of Chironomus tentans have been analyzed by the Southwestern technique. Both the salivary gland and the epithelial cell 42-kDa polypeptides were found to be single-stranded DNA-binding proteins. They bind to sin...

journal_title：Biochemical and biophysical research communications

authors： Stigare J,Egyhazi E

更新日期：1991-05-15 00:00:00

abstract：:Tetrodotoxin-binding sites were covalently labelled with a highly tritiated derivative of tetrodotoxin. Cross-linking experiments, using dissucinimidyl suberate, on partially purified tetrodotoxin-binding component from electroplax of Electrophorus electricus, revealed covalent labelling of a single polypeptide chain ...

journal_title：Biochemical and biophysical research communications

authors： Lombet A,Norman RI,Lazdunski M

更新日期：1983-07-18 00:00:00

abstract：:Two-dimensional polyacrylamide gel electrophoresis (2-DE) profiles of human lung squamous carcinoma tissue and paired surrounding normal bronchial epithelial tissue were compared. Selected differential protein-spots were identified with peptide mass fingerprinting based on matrix-assisted laser desorption/ionization t...

journal_title：Biochemical and biophysical research communications

authors： Li C,Chen Z,Xiao Z,Wu X,Zhan X,Zhang X,Li M,Li J,Feng X,Liang S,Chen P,Xie JY

更新日期：2003-09-12 00:00:00

abstract：:Within the first external loop of mouse and human TRESK subunits one or two N-glycosylation consensus sites were identified, respectively. Using site directed mutagenesis and Western immunoblotting a single residue of both orthologues was found to be glycosylated upon heterologous expression. Two-electrode voltage-cla...

journal_title：Biochemical and biophysical research communications

authors： Egenberger B,Polleichtner G,Wischmeyer E,Döring F

更新日期：2010-01-08 00:00:00

abstract：:The molecular mechanisms of multiple myeloma are not well defined. EEN is an endocytosis-regulating molecule. Here we report that EEN regulates the proliferation and survival of multiple myeloma cells, by regulating IGF-1 secretion. In the present study, we observed that EEN expression paralleled with cell proliferati...

journal_title：Biochemical and biophysical research communications

authors： Huang EW,Xue SJ,Li XY,Xu SW,Cheng JD,Zheng JX,Shi H,Lv GL,Li ZG,Li Y,Liu CH,Chen XH,Liu H,Li J,Liu C

更新日期：2014-05-02 00:00:00

abstract：:Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders and is characterized by impaired attention, hyperactivity, and impulsivity. While multiple etiologies are implicated in ADHD, its underlying mechanism(s) remain unclear. Although previous studies have suggested dysre...

journal_title：Biochemical and biophysical research communications

authors： Nguyen Nguyen HT,Kato H,Sato H,Yamaza H,Sakai Y,Ohga S,Nonaka K,Masuda K

更新日期：2019-06-11 00:00:00

abstract：:This investigation is aimed to determine whether the biosynthesis of H(2)S, an endogenous vasodilator gas, is altered in the streptozotocin-diabetic rat. Plasma H(2)S concentration as well as the activity, and expression, of H(2)S synthesizing enzymes (namely cystathionine-gamma-lyase (CSE) and cystathionine-beta-synt...

journal_title：Biochemical and biophysical research communications

authors： Yusuf M,Kwong Huat BT,Hsu A,Whiteman M,Bhatia M,Moore PK

更新日期：2005-08-12 00:00:00

abstract：:In the present study, we characterized two new SF-1 binding sites, SF-209 and SF-98, in the promoter of the human ACTH receptor (hACTH-R) gene. Both sites, together with the previously described SF-35 site, are required for full constitutive activity of this gene. This was demonstrated by the use of constructs contain...

journal_title：Biochemical and biophysical research communications

authors： Naville D,Penhoat A,Durand P,Begeot M

更新日期：1999-02-05 00:00:00

abstract：:The aim of this study was to understand the mechanism of action through which carnosine (beta-alanyl-L-histidine) acts as a quencher of cytotoxic alpha,beta-unsaturated aldehydes, using 4-hydroxy-trans-2,3-nonenal (HNE) as a model aldehyde. In phosphate buffer solution (pH 7.4), carnosine was 10 times more active as a...

journal_title：Biochemical and biophysical research communications

authors： Aldini G,Carini M,Beretta G,Bradamante S,Facino RM

更新日期：2002-11-15 00:00:00

abstract：:Ubiquitylation is an essential posttranslational protein modification that is implicated in a diverse array of cellular functions. Although cells contain eight structurally distinct types of polyubiquitin chains, detailed function of several chain types including K29-linked chains has remained largely unclear. Current...

journal_title：Biochemical and biophysical research communications

authors： Tsuchiya H,Tanaka K,Saeki Y

更新日期：2013-06-28 00:00:00

abstract：:Human artificial chromosome (HAC) has several advantages as a gene therapy vector, including stable episomal maintenance and the ability to carry large gene inserts. Induced pluripotent stem (iPS) cells also have a great potential for gene therapy, which can be generated from an individual's own tissues and contribute...

journal_title：Biochemical and biophysical research communications

authors： Yakura Y,Ishihara C,Kurosaki H,Kazuki Y,Komatsu N,Okada Y,Doi T,Takeya H,Oshimura M

更新日期：2013-02-08 00:00:00

abstract：:Circadian rhythmic disorders induced by high-fat diet are associated with metabolic diseases. Resveratrol could improve metabolic disorder, but few reports focused on its effects on circadian rhythm disorders in a variety of studies. The aim of the present study was to analyze the potential effects of resveratrol on h...

journal_title：Biochemical and biophysical research communications

authors： Sun L,Wang Y,Song Y,Cheng XR,Xia S,Rahman MR,Shi Y,Le G

更新日期：2015-02-27 00:00:00

abstract：:Limited proteolysis converts the 39200 molecular weight catalytic domain of rat tyrosine hydroxylase to a monomer with a molecular weight of 37600. The purified monomer is almost fully active, with minor changes in kinetic parameters at pH 7. Mass spectral analysis and N-terminal sequencing of the proteolytically gene...

journal_title：Biochemical and biophysical research communications

authors： Lohse DL,Fitzpatrick PF

更新日期：1993-12-30 00:00:00

abstract：:Sorting motifs are involved in the transport of diverse proteins. In the present study, we identified a hydrophobic peptide (WRPWRNFWWSIRVPWRRN) that was able to target enhanced green fluorescent protein- or DsRed2-enriched vesicular-like sub-compartments of the endoplasmic reticulum (ER). Analysis of mutation constru...

journal_title：Biochemical and biophysical research communications

authors： Nie YW,Wang M,Zhang P,Huan L,Liu DJ

更新日期：2016-04-22 00:00:00

abstract：:Two fragments of the E. coli rrnB ribosomal RNA P1 promoter Upstream Activation Region exhibit a constant gel retardation, over a polyacrylamide gel concentration range of 3% to 10%. Gel retardation is usually seen to increase with polyacrylamide gel concentration as in the case of the 219 base pair Crithidia fascicul...

journal_title：Biochemical and biophysical research communications

authors： Wheeler D

更新日期：1993-05-28 00:00:00

abstract：:Helicobacter pylori is a bacterium that causes chronic active gastritis and peptic ulcers. Drugs targeting H. pylori phosphopantetheine adenylyltransferase (HpPPAT), which is involved in CoA biosynthesis, may be useful. Herein, we report the expression in Escherichia coli and purification of recombinant HpPPAT and des...

journal_title：Biochemical and biophysical research communications

authors： Cheng CS,Chen CH,Luo YC,Chen WT,Chang SY,Lyu PC,Kao MC,Yin HS

更新日期：2011-05-06 00:00:00