The catalytic mechanism of Escherichia coli aspartate carbamoyltransferase: a molecular modelling study.

abstract：:Human bone marrow cells express both a truncated and full-length form of the erythropoietin receptor (EpoR-T and EpoR-F, respectively). Transfection experiments using the murine interleukin (IL)-3-dependent cell line, Ba/F3, revealed that the cells coexpressing EpoR-F and EpoR-T (Ba/F3-FT) were more likely to undergo ...

journal_title：Biochemical and biophysical research communications

authors： Shimizu R,Komatsu N,Nakamura Y,Nakauchi H,Nakabeppu Y,Miura Y

更新日期：1996-05-06 00:00:00

abstract：:The presence of at least two distinct Mg2+- or Mn2+-dependent, Ca2+-independent endonuclease activities was shown in the myeloid leukemia cell line P39. One of them was recovered from nuclear extracts and the other from a cytoplasmic fraction. The molecular size of the former was 30 kDa in both gel filtration and acti...

journal_title：Biochemical and biophysical research communications

authors： Kawabata H,Anzai N,Masutani H,Hirama T,Hishita T,Dodo M,Masuda T,Yoshida Y,Okuma M

更新日期：1997-04-07 00:00:00

abstract：:Glucocorticoids inhibit prostaglandin biosynthesis by inducing the formation of lipocortins. In human amnion cells dexamethasone elicited a concentration-dependent increase in prostaglandin production and raised intracellular lipocortin 1 concentrations. Dexamethasone could also potentiate the epidermal growth factor ...

journal_title：Biochemical and biophysical research communications

authors： Mitchell MD,Lytton FD,Varticovski L

更新日期：1988-02-29 00:00:00

abstract：:The localization of gene expression of a low M(r) GTP-binding protein, ram p25, was examined throughout the entire brain of adult rat by in situ hybridization. ram-mRNA was expressed predominantly in anterior and intermediate lobes of pituitary gland (hypophysis), and weakly in hippocampal formation. In other parts of...

journal_title：Biochemical and biophysical research communications

authors： Nagata K,Sakagami H,Kondo H,Nozawa Y

更新日期：1995-12-26 00:00:00

abstract：:Licochalcone (LA) is a novel estrogenic flavonoid isolated from PC-SPES composition herb licorice root that was reported to show significant antitumor activity in various malignant human cell lines. To better understand its anti-CaP activities, we have investigated LA-elicited growth control and induction of apoptosis...

journal_title：Biochemical and biophysical research communications

authors： Fu Y,Hsieh TC,Guo J,Kunicki J,Lee MY,Darzynkiewicz Z,Wu JM

更新日期：2004-09-10 00:00:00

abstract：:Humoral hypercalcemia of malignancy (HHM) occurs when secretion of parathyroid hormone-related peptide (PTHrP) by cancer cells causes hypercalcemia in the absence of skeletal metastases. High extracellular calcium (Ca(2+)(o)) increases secretion of PTH-like bioactivity by rat H-500 leydig cells, a transplantable model...

journal_title：Biochemical and biophysical research communications

authors： Sanders JL,Chattopadhyay N,Kifor O,Yamaguchi T,Brown EM

更新日期：2000-03-16 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. Inhibitors of CaMKII are useful tools for investigating the CaMKII functions. Here we identified a novel CaMKII inhibitor protein (CaM-KIIN) from the human dendritic cell cDNA...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Li N,Yu J,Zhang W,Cao X

更新日期：2001-07-13 00:00:00

abstract：:The conformations of the neuropeptide galanin in water and trifluoroethanol solutions have been examined by 1H NMR spectroscopy. Analysis of two-dimensional NMR experiments enabled the assignment of virtually all the 1H resonances of galanin in trifluoroethanol solution and many of the 1H resonances in aqueous solutio...

journal_title：Biochemical and biophysical research communications

authors： Wennerberg AB,Cooke RM,Carlquist M,Rigler R,Campbell ID

更新日期：1990-02-14 00:00:00

abstract：BACKGROUND:PTK6 is involved in cell proliferation, invasion and migration. Patients with lower PTK6 expression predicts poor prognosis of LSCC. However, the mechanism of PTK6 in LSCC progression remains unclear. We investigated the role of PTK6 in the pathogenesis of LSCC. METHODS:Human LSCC tissues and paired adjacen...

journal_title：Biochemical and biophysical research communications

authors： Wu D,Zhang X,Liu Z,Yan H,Mai J,Zhao Z,Zhong Q,Liu X

更新日期：2018-09-10 00:00:00

abstract：:In epithelial cells progression through the G1 phase of the cell cycle and preparing the cell for the S phase is regulated by cyclin D1-cdk4. Cells that express the retinoblastoma protein (pRb) are dependent on cyclin D1-cdk4 activity for their proliferation while cells that do not express pRb are not. Overexpression ...

journal_title：Biochemical and biophysical research communications

authors： Kent LL,Hull-Campbell NE,Lau T,Wu JC,Thompson SA,Nori M

更新日期：1999-07-14 00:00:00

abstract：:Hypercoagulability is associated with chronic kidney disease (CKD). Tissue factor/factor VIIa complex and factor Xa in the coagulation cascade are known to activate protease-activated receptor 2 (PAR2), and to cause inflammation and tissue injury. Although PAR2 is highly expressed in the kidney, it is unclear whether ...

journal_title：Biochemical and biophysical research communications

authors： Hayashi S,Oe Y,Fushima T,Sato E,Sato H,Ito S,Takahashi N

更新日期：2017-01-29 00:00:00

abstract：:Hydrogen sulfide (H2S), a gaseous signaling molecule produced by cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS), influences bone remodeling in many ways. Osteoclasts play an important role in bone remodeling during tooth movement induced by mechanical loading, which increases the rate of tooth movement...

journal_title：Biochemical and biophysical research communications

authors： Mo S,Hua Y

更新日期：2018-06-22 00:00:00

abstract：:After a peripheral nerve injury, the remaining Schwann cells undergo proliferation and adopt a migratory phenotype to prepare for the regeneration of nerves. Celsr2 has been reported to play an important role in the development and maintenance of the function of the nervous system. However, the role and mechanism of C...

journal_title：Biochemical and biophysical research communications

authors： Zhou X,Zhan Z,Tang C,Li J,Zheng X,Zhu S,Qi J

更新日期：2020-12-17 00:00:00

abstract：:The concept of a glycolytic cancer cell was introduced by Warburg over 70 years ago. This perception has since become the rationale that drives a considerable proportion of basic research on cancer, and it influences the current strategies for the diagnosis, monitoring, and treatment of cancer. Here we review the data...

journal_title：Biochemical and biophysical research communications

authors： Zu XL,Guppy M

更新日期：2004-01-16 00:00:00

abstract：:The microbial degradative characteristics of butyl benzyl phthalate (BBP) were investigated by the Gordonia sp. strain MTCC 4818 isolated from creosote-contaminated soil. The test organism can utilize a number of phthalate esters as sole sources of carbon and energy, where BBP was totally degraded within 4 days under ...

journal_title：Biochemical and biophysical research communications

authors： Chatterjee S,Dutta TK

更新日期：2003-09-12 00:00:00

abstract：:Intricate cross-talks exist among multiple post-translational modifications that play critical roles in various cellular events, such as the control of gene expression and regulation of protein function. Here, the cross-talk between O-GlcNAcylation and ubiquitination was investigated in HEK293T cells. By PCR array, 84...

journal_title：Biochemical and biophysical research communications

authors： Feng Z,Hui Y,Ling L,Xiaoyan L,Yuqiu W,Peng W,Lianwen Z

更新日期：2013-08-23 00:00:00

abstract：:We have reported previously that X-irradiated MOLT-4 cells during their rapid cell death exhibited dose and time dependently a new protein named p41 detected by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE). An antibody, AM-1, raised against partial peptide of p41 stained two spots, p41 and p42, unexpe...

journal_title：Biochemical and biophysical research communications

authors： Morita A,Suzuki N,Matsumoto Y,Hirano K,Enomoto A,Zhu J,Sakai K

更新日期：2000-11-30 00:00:00

abstract：:Unbalanced DNA mixture is still a difficult problem for forensic practice. DIP-STRs are useful markers for detection of minor DNA but they are not widespread in the human genome and having long amplicons. In this study, we proposed a novel type of genetic marker, termed DIP-SNP. DIP-SNP refers to the combination of IN...

journal_title：Biochemical and biophysical research communications

authors： Liu Z,Liu J,Wang J,Chen D,Liu Z,Shi J,Li Z,Li W,Zhang G,Du B

更新日期：2018-03-04 00:00:00

abstract：:We have compared the sequence and gene order of meta-cleavage pathway operons from alpha- and gamma-subgroups of the Proteobacteria with operons from Burkholderia sp. strain RP007 which belongs to the beta-subgroup of the Proteobacteria. Burkholderia RP007 was isolated for its ability to degrade phenanthrene and conta...

journal_title：Biochemical and biophysical research communications

authors： Laurie AD,Lloyd-Jones G

更新日期：1999-08-19 00:00:00

abstract：:Mutations in protein kinase Cgamma (PKCgamma) cause the neurodegenerative disease spinocerebellar ataxia type 14 (SCA14). In this study, expression of an extensive panel of known SCA14-associated PKCgamma mutations as fusion proteins in cell culture led to the consistent formation of cytoplasmic aggregates in response...

journal_title：Biochemical and biophysical research communications

authors： Doran G,Davies KE,Talbot K

更新日期：2008-08-01 00:00:00

abstract：INTRODUCTION:SIRT2 is a NAD(+)-dependent deacetylases and associated with numerous processes such as infection, carcinogenesis, DNA damage and cell cycle regulation. However, the role of SIRT2 in inflammatory process in macrophage remains unclear. MATERIALS AND METHODS:In the present study, we have evaluated the regul...

journal_title：Biochemical and biophysical research communications

authors： Lee AS,Jung YJ,Kim D,Nguyen-Thanh T,Kang KP,Lee S,Park SK,Kim W

更新日期：2014-08-08 00:00:00

abstract：:We have reported that activation of protein kinase C (PKC) increases ecto-5'-nucleotidase activity, which may contribute to the infarct size-limiting effect of ischemic preconditioning. Since we have reported that Ca(2+)- and phospholipid-sensitive PKC is activated due to ischemic preconditioning, we further tested 1)...

journal_title：Biochemical and biophysical research communications

authors： Kitakaze M,Funaya H,Minamino T,Node K,Sato H,Ueda Y,Okuyama Y,Kuzuya T,Hori M,Yoshida K

更新日期：1997-10-09 00:00:00

abstract：:The interaction between isolated adrenal medullary plasma membranes and chromaffin granules has been proposed as a cell-free model for exocytosis. Phosphorylation experiments showed that isolated chromaffin granules as well as isolated plasma membranes contain protein kinases and phosphate accepting membranous protein...

journal_title：Biochemical and biophysical research communications

authors： Konings F,De Potter W

更新日期：1983-01-14 00:00:00

abstract：:Interleukin (IL)-19 belongs to the IL-10 family which includes IL-19, IL-20, IL-22, AK155, and MDA-7. IL-10 is a potent immunomodulatory cytokine with implications for pathogenesis in various autoimmune diseases. Polymorphism of the IL-10 promoter region correlates with disease outcome. To understand the gene regulati...

journal_title：Biochemical and biophysical research communications

authors： Chen PJ,Wei CC,Wang C,Chen FW,Hsu YH,Chang MS

更新日期：2006-06-09 00:00:00

abstract：:The Drosophila Toll-1 receptor is involved in embryonic development, innate immunity, and tissue homeostasis. Currently, as a ligand for the Toll-1 receptor, only Spätzle (Spz) has been identified and characterized. We previously reported that Drosophila larva-derived tissue extract contains ligand activity for the To...

journal_title：Biochemical and biophysical research communications

authors： Nonaka S,Kawamura K,Hori A,Salim E,Fukushima K,Nakanishi Y,Kuraishi T

更新日期：2018-11-30 00:00:00

abstract：:Earlier, we showed that antibodies specific for human serum albumin are able to bind to erythrocyte-associated albumin and inhibit complement mediated hemolysis. In the present study we determine if inhibition is occurring at the membrane attack phase of complement activation or at an earlier step. We show that althou...

journal_title：Biochemical and biophysical research communications

authors： Houle JJ,Hoffmann EM

更新日期：1994-04-15 00:00:00

abstract：:Osteoporosis is a common bone disorder with adverse effects on oral osseointegration, and the effects of metformin on bone metabolism have received increasing attention. The aim of the present study was to test the hypothesis that metformin promoted osteogenesis of bone mesenchymal stem cells (BMSCs) and osseointegrat...

journal_title：Biochemical and biophysical research communications

authors： Lin J,Xu R,Shen X,Jiang H,Du S

更新日期：2020-10-15 00:00:00

abstract：:Explaining why type I collagens are preferentially preserved in the geological time scale remains a challenge. Several pieces of evidence indicate that its rich content in the bone and its unique, stable structure played key roles in its preservation. By considering the distinct thermal stability of amino acids, we re...

journal_title：Biochemical and biophysical research communications

authors： Wang SY,Cappellini E,Zhang HY

更新日期：2012-05-25 00:00:00

abstract：:1-Methyl-4-phenylpyridinium (MPP+)-treated human neuroblastoma SH-SY5Y cells have been generally accepted as a cellular model for Parkinson's disease. To understand comprehensive metabolic disturbances in this model, both cell lysates and culture supernatants were subjected to metabolomic analysis. As expected from th...

journal_title：Biochemical and biophysical research communications

authors： Amo T,Oji Y,Saiki S,Hattori N

更新日期：2019-11-12 00:00:00

abstract：:Aplastic anemia (AA) is a serious blood system disease that threatens human health. At present, the main cause of this disease is believed to be immune hyperfunction. However, the specific metabolic mode involved in the occurrence of lymphocytes in AA is still unknown. In addition, whether rapamycin, a specific blocke...

journal_title：Biochemical and biophysical research communications

authors： Liu SL,Zhou YM,Tang DB,Zhou N,Zheng WW,Tang ZH,Duan CW,Chen J

更新日期：2019-10-15 00:00:00