Paradoxical stimulation of both lipocortin and prostaglandin production in human amnion cells by dexamethasone.

Abstract:

:Glucocorticoids inhibit prostaglandin biosynthesis by inducing the formation of lipocortins. In human amnion cells dexamethasone elicited a concentration-dependent increase in prostaglandin production and raised intracellular lipocortin 1 concentrations. Dexamethasone could also potentiate the epidermal growth factor (EGF)-induced stimulation of prostaglandin production. EGF alone or in combination with dexamethasone increased lipocortin 1 formation in amnion cells. Human amnion cells may provide a unique insight into interactions between glucocorticoids, lipocortin and eicosanoid biosynthesis.

authors

Mitchell MD,Lytton FD,Varticovski L

doi

10.1016/0006-291x(88)90569-4

subject

Has Abstract

pub_date

1988-02-29 00:00:00

pages

137-41

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(88)90569-4

journal_volume

151

pub_type

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