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Identification and localization of gene expression of a low M(r) GTP-binding protein, ram p25 in pituitary gland.

Abstract：

:The localization of gene expression of a low M(r) GTP-binding protein, ram p25, was examined throughout the entire brain of adult rat by in situ hybridization. ram-mRNA was expressed predominantly in anterior and intermediate lobes of pituitary gland (hypophysis), and weakly in hippocampal formation. In other parts of brain, no significant expression of ram-mRNA was detected, indicating that ram p25 may have an important role(s) in adenohypophysis. In 15-day-fetal rat, the mRNA was observed to be expressed strongly in the primitive anterior lobe of pituitary gland. The ram p25 was also detected in bovine pituitary gland by a specific antibody and was purified to near homogeneity by stepwise column chromatographies. Biochemical characterization of the purified ram p25 revealed that the profile of [35S]GTP gamma S-binding activity was almost the same as that of recombinant ram p25 expressed in E. coli.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nagata K,Sakagami H,Kondo H,Nozawa Y

doi

10.1006/bbrc.1995.2899

subject

Has Abstract

pub_date

1995-12-26 00:00:00

pages

1223-30

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)72899-9

journal_volume

217

pub_type

杂志文章

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