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SPTLC1 inhibits cell growth via modulating Akt/FOXO1 pathway in renal cell carcinoma cells.

Abstract：

:Serine palmitoyltransferase long chain-1 (SPTLC1), which is the rate-limiting enzyme for sphingolipid biosynthesis, has been indicated to be essential for carcinoma cell survival and proliferation in recent, but its role in the regulation of renal cell carcinoma (RCC) remains unknown. In the present study, we found that SPTLC1 expression was significantly decreased in RCC tissues compared to non-tumor tissues, and low SPTLC1 expression was associated with poor overall survival of RCC patients. In addition, our results revealed that forced expression of SPTLC1 could significantly inhibit cell growth in vitro and in vivo via, at least in part, modulating Akt/FOXO1 signaling pathway, thus representing a novel role of SPTLC1 in the regulation of tumor growth in RCC for the first time.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kong Z,Guo X,Zhao Z,Wu W,Luo L,Zhu Z,Yin S,Cai C,Wu W,Wang D,Liu Y,Duan X

doi

10.1016/j.bbrc.2019.09.073

subject

Has Abstract

pub_date

2019-11-26 00:00:00

pages

1-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(19)31800-5

journal_volume

520

pub_type

杂志文章

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