Abstract:
:Cigarette smoke is a major risk factor for lung cancer and respiratory infections. This increased susceptibility may result from cigarette smoke-induced impairment of the immune system. In this study, we evaluated the effect of nicotine on the production of inflammatory mediators by activated macrophages. Pretreatment with nicotine caused a significant inhibition of LPS-induced IL-1, IL-8, and PGE2 expression at the transcriptional level in U937 cells. Nicotine inhibited the activation of a transcription factor, NF-kappaB, which in turn, binds to and mediates transcriptional activation of these genes. These inhibitory effects of nicotine may contribute to cigarette smoke-induced immunosuppression.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Sugano N,Shimada K,Ito K,Murai Sdoi
10.1006/bbrc.1998.9599subject
Has Abstractpub_date
1998-11-09 00:00:00pages
25-8issue
1eissn
0006-291Xissn
1090-2104pii
S0006291X98995997journal_volume
252pub_type
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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doi:10.1006/bbrc.1998.9150
更新日期:1998-08-19 00:00:00
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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更新日期:2017-01-22 00:00:00
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journal_title:Biochemical and biophysical research communications
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doi:10.1006/bbrc.1997.7690
更新日期:1997-11-26 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1006/bbrc.1999.1750
更新日期:1999-12-09 00:00:00
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pub_type: 杂志文章
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更新日期:2005-01-28 00:00:00