Significance of isomerization in hydroxocobalamin.

abstract：:Oscillatory gene expression plays an important role in somite segmentation during the early developmental stages of vertebrates. Recent experimental studies have shown that microRNA can regulate gene expression by stimulating degradation of mRNA and/or repression of translation. In this communication, we incorporate m...

journal_title：Biochemical and biophysical research communications

authors： Xie ZR,Yang HT,Liu WC,Hwang MJ

更新日期：2007-07-06 00:00:00

abstract：:Vascular calcification increases the risk of developing cardiovascular disease, and it is closely associated with metabolic disorders such as diabetes mellitus and non-alcoholic fatty liver disease. We investigated whether the activators of AMP-activated protein kinase (AMPK), metformin, resveratrol, and exendin-4, im...

journal_title：Biochemical and biophysical research communications

authors： Lee J,Hong SW,Kim MJ,Kwon H,Park SE,Rhee EJ,Lee WY

更新日期：2020-09-17 00:00:00

abstract：:ERK8 is the most recent addition for the MAPK family, and its mechanism of activation and function are not yet known, mainly due to the lack of any known physiological stimulator. In this report, we describe the preparation of reagents for the use of a novel method, the ligand interaction scan (LIScan), to study the f...

journal_title：Biochemical and biophysical research communications

authors： Erster O,Seger R,Liscovitch M

更新日期：2010-08-13 00:00:00

abstract：:Polyribosomes were isolated without the use of detergents, irradiated with ultraviolet light and labelled in the presence of (gamma-32P) adenosine 5'-triphosphate. Poly(A)+RNA-protein structures separated by chromatography on oligo (dT)-cellulose contained up to 1o crosslinked proteins as shown by SDS-polyacrylamide g...

journal_title：Biochemical and biophysical research communications

authors： Schweiger A,Kostka G,Weiss E

更新日期：1986-04-14 00:00:00

abstract：:Impermeable ferricyanide stimulates the growth of HeLa cells in absence of fetal bovine serum or other growth factors. A series of impermeable oxidants with redox potentials down to -125 mV stimulate equivalent growth. All of these oxidants are reduced by the transplasma membrane electron transport system. Oxidants wi...

journal_title：Biochemical and biophysical research communications

authors： Sun IL,Crane FL,Löw H,Grebing C

更新日期：1984-12-14 00:00:00

abstract：:Long-term glyburide therapy has been reported to improve glucose-induced insulin secretion in patients with NIDDM. We examined the effects of glyburide on the synthesis and release of insulin and insulin gene expression in isolated islets in vitro. Incubation with glyburide (500 ng/ml) significantly increased insulin ...

journal_title：Biochemical and biophysical research communications

authors： Yamato E,Ikegami H,Tahara Y,Fukuda M,Cha T,Kawaguchi Y,Fujioka Y,Noma Y,Shima K,Ogihara T

更新日期：1994-02-28 00:00:00

abstract：:Functional biopolymer scaffolds are in high demand for tissue regeneration. In this study, we incorporated functionalized CNT in collagen or silk protein solution to generate biocomposite fibers by electrospinning. The addition of CNT reinforced the strength of the scaffolds and rendered the fibers electrical conducti...

journal_title：Biochemical and biophysical research communications

authors： Chi N,Wang R

更新日期：2018-09-26 00:00:00

abstract：:p21-activated kinase (PAK) and Rho-associated kinase (Rho-kinase) have been shown to induce Ca(2+)-independent contraction of smooth muscle. PAK-induced contraction of Triton-skinned smooth muscle correlates with increased phosphorylation of caldesmon and desmin, although the role of desmin phosphorylation has remaine...

journal_title：Biochemical and biophysical research communications

authors： Ohtakara K,Inada H,Goto H,Taki W,Manser E,Lim L,Izawa I,Inagaki M

更新日期：2000-06-16 00:00:00

abstract：:Sphingolipids have been reported to regulate the growth and death of mammalian and yeast cells, but their precise mechanisms are unknown. In this paper, it was shown that the deletion of the oxysterol binding protein homologue 3 (OSH3) gene confers hyper resistance against ISP-1, an inhibitor of sphingolipid biosynthe...

journal_title：Biochemical and biophysical research communications

authors： Yano T,Inukai M,Isono F

更新日期：2004-02-27 00:00:00

abstract：:To date, little is known about the molecular mechanisms controlling the regulation of phospholipase C-delta1 (PLC-delta1) gene expression. To understand the mechanisms responsible for the regulation of PLC-delta1 gene expression, the 5'-flanking region of the mouse PLC-delta1 gene was isolated from a mouse genomic DNA...

journal_title：Biochemical and biophysical research communications

authors： Kim JK,Lee WK,Nam HW,Lee KH,Han H,Rha HK,Jun TY,Kim KS,Choi CR

更新日期：2000-06-24 00:00:00

abstract：:Actin-myosin interaction in aortic actomyosin reportedly requires phosphorylation of the 20,000 dalton myosin light chains. A spontaneously active phosphatase which dephosphorylates phosphorylase a and isolated phosphorylated cardiac myosin light chains was extracted from bovine aortic smooth muscle. This enzyme, when...

journal_title：Biochemical and biophysical research communications

authors： Di Salvo J,Gifford D,Bialojan C,Rüegg JC

更新日期：1983-03-29 00:00:00

abstract：:The distribution, labeling and interrelationship of microsomal and lysosomal dolichol and dolichyl-P in rat liver was investigated. After membrane induction with phenobarbital, N-nitrosodiethylamine and diethylhexylphthalate, the amount of microsomal and lysosomal dolichols are modulated independently. Liposomal label...

journal_title：Biochemical and biophysical research communications

authors： Edlund C,Chojnacki T,Dallner G

更新日期：1983-09-30 00:00:00

abstract：:Glial cells have been shown to induce enzyme activities, which are characteristically high in brain capillaries, in cerebral and non cerebral endothelial cells in culture. We evaluated the activity of gamma-glutamyl transpeptidase (gamma GT) in freshly isolated (ex vivo) bovine blood (BEC) and lymphatic (LEC) endothel...

journal_title：Biochemical and biophysical research communications

authors： Weber E,Lorenzoni P,Raffaelli N,Cavina N,Sacchi G

更新日期：1996-08-23 00:00:00

abstract：:The Mrr protein of Escherichia coli K12 is a cryptic Type IV restriction endonuclease whose activity appears to be triggered by high pressure stress. In this report we used high pressure to isolate and analyze several Mrr mutants, and generated a new structural model of the Mrr protein. The activity of a number of spo...

journal_title：Biochemical and biophysical research communications

authors： Orlowski J,Mebrhatu MT,Michiels CW,Bujnicki JM,Aertsen A

更新日期：2008-12-19 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a major cause of heart failure in younger individuals. Its prognosis is poor with 40-50% of patients dying within 2 years after diagnosis. Although the etiology of DCM is poorly understood, there is increasing evidence that DCM may represent an autoimmune disease in a significant subset...

journal_title：Biochemical and biophysical research communications

authors： Nickenig G,Wolff M,Stäblein A,Pfister H,Böhm M

更新日期：1999-12-20 00:00:00

abstract：:Advanced glycation end products (AGE) are involved in tissue damage and remodeling. This study investigated whether AGE could elicit inflammatory and fibrogenic reactions in fibroblast cell line MRC-5 cells via autocrine production of aldosterone and if nifedipine could block the AGE actions through mineralocorticoid ...

journal_title：Biochemical and biophysical research communications

authors： Matsui T,Takeuchi M,Yamagishi S

更新日期：2010-05-28 00:00:00

abstract：:Activation of the classical IκB kinases (IKKα and IKKβ) was previously shown to contribute to obesity-induced inflammation and insulin resistance. Using knockout mice, we investigated whether the related isoform IKKε plays a similar metabolic role. IKKε(-/-) mice had reduced body weight, leptin levels, as well as high...

journal_title：Biochemical and biophysical research communications

authors： Scheja L,Heese B,Seedorf K

更新日期：2011-04-08 00:00:00

abstract：:Akt signaling plays a pivotal role in acute myeloid leukemia (AML) development and progression. In the present study, we evaluated the potential anti-AML activity by a novel Akt kinase inhibitor A-674563. Our results showed that A-674563 dose-dependently inhibited survival and proliferation of U937 AML cells and six l...

journal_title：Biochemical and biophysical research communications

authors： Xu L,Zhang Y,Gao M,Wang G,Fu Y

更新日期：2016-04-15 00:00:00

abstract：:Britannin (Bri), isolated from Inula aucheriana, is a sesquiterpene lactone (SL), a class of secondary metabolites. Previous studies have suggested the anti-cancer potential of Bri; however, the molecular mechanism remains elusive. The present study investigated the effects of Bri on liver cancer progression. Our find...

journal_title：Biochemical and biophysical research communications

authors： Cui YQ,Liu YJ,Zhang F

更新日期：2018-03-11 00:00:00

abstract：:Abnormal plasma ascorbic acid (AA) and dehydroascorbic acid (DHAA) levels observed in diabetes may be correlated to a deficiency in the recycling of AA. Ascorbic acid and DHAA levels are altered in diabetic liver in the present study. In addition, a coupling of the hexose monophosphate (HMP) shunt by way of NADPH to g...

journal_title：Biochemical and biophysical research communications

authors： Bode AM,Yavarow CR,Fry DA,Vargas T

更新日期：1993-03-31 00:00:00

abstract：:Autophosphorylation of phosphorylase kinase from rabbit skeletal muscle was stimulated by acidic phospholipids such as phosphatidic acid (PA), phosphatidylinositol, and phosphatidyl-serine. PA stimulated an initial velocity of autophosphorylation 3.8-fold. When fully autophosphorylated, about 11 mol of phosphate per t...

journal_title：Biochemical and biophysical research communications

authors： Negami AI,Sasaki H,Yamamura H

更新日期：1985-09-16 00:00:00

abstract：:Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system and is mediated by complement-dependent cytotoxicity (CDC) of NMO-specific immunoglobulin G (IgG) antibodies (NMO-IgG). Glycyrrhizic acid (GA) has numerous pharmacological effects including inhibition of the complement pa...

journal_title：Biochemical and biophysical research communications

authors： Kim JS,Cheon S,Kim SW,Kim B,Kim H,Park KD,Kim SM

更新日期：2016-09-16 00:00:00

abstract：:Antibody-dependent cell-mediated cytotoxicity bridges humoral immunity and cellular immunity. Thus vaccine candidates which can elicit both broadly neutralizing antibodies and potent antibody-dependent cell-mediated cytotoxicity (ADCC) are recommended. Previously, a panel of functional epitopes that can elicit ADCC ef...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Liu M,Ding N,Li Y,Shao J,Zhu M,Xie Z,Sun K

更新日期：2018-09-10 00:00:00

abstract：:Cardiac differentiation involves a cascade of coordinated gene expression that regulates cell proliferation and matrix protein formation in a defined temporo-spatial manner. The zinc-finger-containing transcription factor has been implicated as a critical regulator of multiple cardiac-expressed genes as well as a regu...

journal_title：Biochemical and biophysical research communications

authors： Liu H,Zhu C,Luo J,Wang Y,Li D,Li Y,Zhou J,Yuan W,Ou Y,Liu M,Wu X

更新日期：2004-07-16 00:00:00

abstract：:Colorectal carcinoma (CRC) is one of the most frequently diagnosed cancers and the leading cause of cancer-related death for both men and women. Recent studies have revealed that a small sub-population of cancer cells, termed cancer stem-like cells (CSCs)/cancer-initiating cells (CICs), are endowed with tumor-initiati...

journal_title：Biochemical and biophysical research communications

authors： Wang L,Hirohashi Y,Ogawa T,Shen M,Takeda R,Murai A,Yamamoto E,Kubo T,Nakatsugawa M,Kanaseki T,Tsukahara T,Nishidate T,Okita K,Kutomi G,Sato N,Takemasa I,Torigoe T

更新日期：2017-04-29 00:00:00

abstract：:Periplasmic proteins of Gram-negative bacteria like Escherichia coli are subjected to immediate affect of environmental fluctuation that may unfold proteins, due to the permeability of the outer membrane to small molecules. They are thus supposedly protected by certain molecular chaperones. Nevertheless, no homologues...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Fu X,Shen J,Zhang H,Hong W,Chang Z

更新日期：2004-04-09 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development...

journal_title：Biochemical and biophysical research communications

authors： Murayama MA,Kakuta S,Maruhashi T,Shimizu K,Seno A,Kubo S,Sato N,Saijo S,Hattori M,Iwakura Y

更新日期：2014-01-03 00:00:00

abstract：:While recent evidence has uncovered that circular RNAs (circRNAs) are vital regulators of carcinogenesis, their role in papillary thyroid cancer (PTC) is not clearly understood. In this study, we reveal that lower levels of circRNA circ-ITCH are expressed in PTC tissues than in normal adjacent tissues. Gain-of-functio...

journal_title：Biochemical and biophysical research communications

authors： Wang M,Chen B,Ru Z,Cong L

更新日期：2018-09-26 00:00:00

abstract：:BIK, a member of the Bcl-2 family, has been reported to induce cell apoptosis but the underlying mechanisms are not well delineated. We used siRNA targeting caspase-12 to examine the effect of caspase-12 on apoptosis induced by BIK. In this study, we show that caspase-12 was activated by BIK. With caspase-12 knocked d...

journal_title：Biochemical and biophysical research communications

authors： Zhao X,Sun Y,Yu H,Ye L,Zhang L,Lu J,Yuan Y,Qian G,Ge S

更新日期：2007-08-10 00:00:00

abstract：:When TT virus (TTV) DNA was quantitated in whole blood and plasma aliquots from 27 viremic individuals by real-time detection PCR that can detect essentially all TTV genotypes, the TTV load was 6.9 +/- 3.5 (mean +/- standard deviation)-fold higher in the whole blood than in the plasma samples [P < 0.002 (paired t test...

journal_title：Biochemical and biophysical research communications

authors： Takahashi M,Asabe S,Gotanda Y,Kishimoto J,Tsuda F,Okamoto H

更新日期：2002-01-11 00:00:00