Ultraviolet light-induced crosslinking of two major phosphoproteins and poly(A)+RNA from free polyribosomes; changes in phosphorylation by inhibitors of transcription and translation.

abstract：:Alisol B-23-acetate (AB23A), a tetracyclic triterpenoid isolated from the rhizome of Alisma orientale, has been reported to exert anti-proliferative activities in human colon, ovarian and gastric cancer cells. However, the anti-cancer effect of this compound on human lung cancer cells has not yet been thoroughly eluci...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Li H,Wang X,Shen T,Wang S,Ren D

更新日期：2018-11-10 00:00:00

abstract：:Succinate-ubiquinone reductase (complex II) is an important enzyme complex in aerobic respiration and the tricarboxylic acid cycle. We recently identified two distinct cDNAs for the human flavoprotein subunit (Fp) from a single individual and demonstrated mRNAs of these two isoforms, Type I Fp and Type II Fp, in skele...

journal_title：Biochemical and biophysical research communications

authors： Tomitsuka E,Goto Y,Taniwaki M,Kita K

更新日期：2003-11-21 00:00:00

abstract：:The purpose of this study was to elucidate the involvement of H2O2 production in cisplatin-induced nephrotoxicity. The S3 cells were more sensitive than OMCT cells in cell viability and H2O2 production during cisplatin treatment. The cytotoxicity and H2O2 production induced by cisplatin were terminated by treatment wi...

journal_title：Biochemical and biophysical research communications

authors： Tsutsumishita Y,Onda T,Okada K,Takeda M,Endou H,Futaki S,Niwa M

更新日期：1998-01-14 00:00:00

abstract：:The effect of the length of ANF peptides on the inhibition of the norepinephrine-induced contraction was studied. Starting from the 26 residues ANF (Arg101-Tyr126), shorter N- and/or C-terminal fragments were produced, either by N-terminal chemical cleavage or C-terminal enzymatic digestion of ANF or both respectively...

journal_title：Biochemical and biophysical research communications

authors： Garcia R,Thibault G,Seidah NG,Lazure C,Cantin M,Genest J,Chrétien M

更新日期：1985-01-16 00:00:00

abstract：:The chemopreventive effect of nitric oxide-releasing aspirin (NO-ASA) against gastrointestinal tumorigenesis was evaluated in Min (APC(Min/+)) mice. NO-ASA consists of a traditional ASA that bears covalently attached to it an NO-releasing moiety. Four groups (N=10) of six-week-old female C57BL/6J APC(Min/+) and the co...

journal_title：Biochemical and biophysical research communications

authors： Williams JL,Kashfi K,Ouyang N,del Soldato P,Kopelovich L,Rigas B

更新日期：2004-01-16 00:00:00

abstract：:The small GTPase Rheb binds and activates mTORC1, which plays a pivotal role in diverse cellular physiologies. To increase our understanding of how Rheb regulates mTORC1 signaling, we set out to identify Rheb binding proteins using shotgun proteomics approaches. In this study, we characterized HSP70, one of the identi...

journal_title：Biochemical and biophysical research communications

authors： Ryu HH,Ha SH

更新日期：2020-12-17 00:00:00

abstract：:Gastric cancer is one of the major causes of cancer death worldwide; however, the mechanism of carcinogenesis is complex and poorly understood. Long non-coding RNA HOTAIR (HOX transcript antisense RNA) recently emerged as a promoter of metastasis in various cancers including gastric cancer. Here we investigated the im...

journal_title：Biochemical and biophysical research communications

authors： Lee NK,Lee JH,Park CH,Yu D,Lee YC,Cheong JH,Noh SH,Lee SK

更新日期：2014-08-22 00:00:00

abstract：:We examined the mechanism of arachidonate release induced by somatostatin-14 (SS14) in CHO-K1 cells overexpressing rat hippocampal somatostatin receptor SSTR4. SSTR4 couples to pertussis toxin (PTX)-sensitive G-protein in CHO cells and does not lead to phosphoinositides breakdown or intracellular calcium ([Ca2+]i) mob...

journal_title：Biochemical and biophysical research communications

authors： Sakanaka C,Ferby I,Waga I,Bito H,Shimizu T

更新日期：1994-11-30 00:00:00

abstract：:The ferromagnetic transduction model proposed by J.L. Kirschvink (Phys. Rev. A (1992) 46, 2178-2184) suggests that the coupling of biogenic magnetic particles in the human brain to mechanosensitive membrane ion gates may provide a mechanism for interactions of environmental magnetic fields with humans. Extremely low f...

journal_title：Biochemical and biophysical research communications

authors： Dobson J,St Pierre T

更新日期：1996-10-23 00:00:00

abstract：:Thioredoxin-interacting protein (TXNIP) has multiple disease-associated functions including inducing oxidative stress by inhibiting the anti-oxidant and thiol reducing activity of thioredoxin (TRX), reducing cellular glucose transport, and is a component of the activated inflammasome complex. Increased expression of T...

journal_title：Biochemical and biophysical research communications

authors： Buyandelger U,Walker DG,Taguchi H,Yanagisawa D,Tooyama I

更新日期：2020-11-19 00:00:00

abstract：:Endostatin, a natural angiogenesis inhibitor, had been identified for years. It opened a new approach for cancer therapy. Sequence analysis revealed that endostatin is the NC1 domain (non-triple-helical domain) of collagen XVIII. In this report, the cDNA of NC1 domain of type VIII collagen (alpha 1) was cloned and exp...

journal_title：Biochemical and biophysical research communications

authors： Xu R,Yao ZY,Xin L,Zhang Q,Li TP,Gan RB

更新日期：2001-11-23 00:00:00

abstract：:In this paper, based on the approach by combining the "functional domain composition" [K.C. Chou, Y. D. Cai, J. Biol. Chem. 277 (2002) 45765] and the pseudo-amino acid composition [K.C. Chou, Proteins Struct. Funct. Genet. 43 (2001) 246; Correction Proteins Struct. Funct. Genet. 2044 (2001) 2060], the Nearest Neighbou...

journal_title：Biochemical and biophysical research communications

authors： Cai YD,Chou KC

更新日期：2003-05-30 00:00:00

abstract：:Glycosylation of endothelin (ET) receptors was found to occur in rat cerebellar and atrial membranes. Specifically, we investigated whether the ETA and ETB receptor subtypes differed in their sensitivity to deglycosylation treatment and whether the two affinity states (nanomolar and picomolar) observed in each recepto...

journal_title：Biochemical and biophysical research communications

authors： Shraga-Levine Z,Sokolovsky M

更新日期：1998-05-19 00:00:00

abstract：:S-Adenosyl-l-methionine (SAM) is the biological methyl-group donor for the enzymatic methylation of numerous substrates including proteins. SAM has been reported to activate smooth muscle derived ryanodine receptor calcium release channels. Therefore, we examined the effects of SAM on the cardiac isoform of the ryanod...

journal_title：Biochemical and biophysical research communications

authors： Kampfer AJ,Balog EM

更新日期：2008-07-11 00:00:00

abstract：:Oxygen has always been recognized as an essential element of many life forms, initially through its role as a terminal electron acceptor for the energy-generating pathways of oxidative phosphorylation. In 1955, Hayaishi et al. [Mechanism of the pyrocatechase reaction, J. Am. Chem. Soc. 77 (1955) 5450-5451] presented t...

journal_title：Biochemical and biophysical research communications

authors： Sligar SG,Makris TM,Denisov IG

更新日期：2005-12-09 00:00:00

abstract：:Lectins (asialo-receptor family) are expressed on a number of tumors that develop peritoneal metastases. To demonstrate that fluorescence imaging based on lectin binding is applicable for a variety of tumors, we conjugated BODIPY to avidin (avidin-BODIPY), and studied the efficacy of tumor targeting in 9 cancer cell l...

journal_title：Biochemical and biophysical research communications

authors： Hama Y,Urano Y,Koyama Y,Choyke PL,Kobayashi H

更新日期：2006-09-29 00:00:00

abstract：:This study was undertaken to determine whether the response of smooth muscle cells to mitogens can be inhibited by inactivating ras with the ral GDS like protein-2 ras-binding domain (RGL2-RBD). RGL2 is a member of the ral GDS family of proteins that contains a carboxy terminal ras-binding domain which binds the GTP l...

journal_title：Biochemical and biophysical research communications

authors： Fischer TH,Brittain J,Trabalzini L,Banes AJ,White GC,Smith CJ,Nichols TC

更新日期：2003-06-13 00:00:00

abstract：:Two peptide analogs of the 37-62 sequence region of the HIV TAT protein bind tightly to the surface of A431 breast carcinoma cells. After conjugation to either of two poorly internalized anti-tumor antibody Fab fragments, the analogs enhanced the in vitro cell surface retention and internalization of the Fab fragments...

journal_title：Biochemical and biophysical research communications

authors： Anderson DC,Nichols E,Manger R,Woodle D,Barry M,Fritzberg AR

更新日期：1993-07-30 00:00:00

abstract：:The potential antiatherogenic actions of the angiotensin II receptor antagonist, losartan were investigated in apolipoprotein (apo) E deficient mice, an animal model with severe hypercholesterolemia and extensive atherosclerosis. In these animals accelerated atherosclerosis is associated with increased lipid peroxidat...

journal_title：Biochemical and biophysical research communications

authors： Keidar S,Attias J,Smith J,Breslow JL,Hayek T

更新日期：1997-07-30 00:00:00

abstract：:Ritonavir, an inhibitor of HIV-1 protease, has been reported to also inhibit the Ca2+-dependent cysteine protease, calpain. We have investigated these claims with an in vitro study of the effect of ritonavir on the m-calpain and mu-calpain isoforms. Ritonavir failed to block either autolytic or hydrolytic calpain acti...

journal_title：Biochemical and biophysical research communications

authors： Cuerrier D,Nie Z,Badley AD,Davies PL

更新日期：2005-02-04 00:00:00

abstract：:We have examined the role of K+ channels in mediating vasorelaxation produced by bacterial lipopolysaccharide (LPS) in endothelial-denuded strips of rat aorta precontracted with phenylephrine (1 microM). Salmonella typhosa LPS (0.1 microgram/ml) caused significant relaxation of tension which peaked at approximately 4h...

journal_title：Biochemical and biophysical research communications

authors： Hall S,Turcato S,Clapp L

更新日期：1996-07-05 00:00:00

abstract：:The Fas/FasL signaling pathway, controlled by nuclear factor-κB (NFκB) at the transcriptional level, is critical for triggering germ cell apoptosis in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell (SC) injury, but the exact regulation mechanism remain unknown. Here, we discovered that expressio...

journal_title：Biochemical and biophysical research communications

authors： Chen S,Dong Y,Xu C,Jiang L,Chen Y,Jiang C,Hou W,Li W

更新日期：2013-11-01 00:00:00

abstract：:Dual effect of dibromothymoquinone ( DBMIB ), inhibitor and reducing agent at the donor side of Photosystem I, was investigated in isolated intact chloroplasts by flash-induced absorbance changes at 820 and 515 nm. We show that in the absence of other electron donors, rereduction of P700+ by DBMIB proceeds at a very l...

journal_title：Biochemical and biophysical research communications

authors： Farineau J,Bottin H,Garab G

更新日期：1984-05-16 00:00:00

abstract：:Oncogenes c-myc, H-ras, c-fos and erb-B were constitutively expressed in immature chick oviduct withdrawn from estrogen administration for 2.5 weeks after 10 d of primary estrogen stimulation. Following secondary estrogen stimulation of the withdrawn chicks, synthesis of egg white proteins is rapidly induced and remai...

journal_title：Biochemical and biophysical research communications

authors： Cohrs RJ,Goswami BB,Sharma OK

更新日期：1988-01-15 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin resistance, dyslipidemia and a systemic pro-inflammatory response, a leading cause of cirrhosis and hepatocellular carcinoma. Here, we showed that PDZ-LIM domain-containing protein 2 (PDLIM2) was an effective suppressor of steatoh...

journal_title：Biochemical and biophysical research communications

authors： Hao YR,Tang FJ,Zhang X,Wang H

更新日期：2018-09-05 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that catalyzes the synthesis of ADP-ribose polymers from NAD(+). The function of PARP-1 is related to important nuclear processes including DNA repair and transcription. Previous studies demonstrated a specific physical interaction between PARP-1 and the trans...

journal_title：Biochemical and biophysical research communications

authors： Oei SL,Shi Y

更新日期：2001-06-08 00:00:00

abstract：:The calmodulin-like domain of calpain is important for the association of the calpain large and small subunits. We expressed the calmodulin-like domains of the large subunits of rabbit mu- and m-calpains and their small subunits in E. coli and purified them to homogeneity. Unlike the full-length subunits, the calmodul...

journal_title：Biochemical and biophysical research communications

authors： Suo S,Koike H,Sorimachi H,Ishiura S,Suzuki K

更新日期：1999-04-02 00:00:00

abstract：:Leigh syndrome (LS) is an incurable, nearly always fatal, neurodegenerative, pediatric disorder that results from respiratory chain failure. The most common mitochondrial DNA (mtDNA) mutations that result in LS are m.8993T→C/G and m.9176T→C/G, which were previously found in several patients with early-onset Leigh synd...

journal_title：Biochemical and biophysical research communications

authors： Ronchi D,Bordoni A,Cosi A,Rizzuti M,Fassone E,Di Fonzo A,Servida M,Sciacco M,Collotta M,Ronzoni M,Lucchini V,Mattioli M,Moggio M,Bresolin N,Corti S,Comi GP

更新日期：2011-08-26 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by the presence of the PML-RARα fusion protein. We have previously found that PML-RARα-regulated miR-125b is highly expressed in APL; however, the characteristics of the regulatory effects and mechanisms of miR-125b involved in APL proliferation have yet to be clarif...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Zeng C,Lu S,Qin T,Yang L,Chen S,Chen J,Li Y

更新日期：2016-09-30 00:00:00

abstract：:The fission yeast S-phase regulator Mcl1, an orthologue of budding yeast Ctf4, is an interacting protein of DNA polymerase alpha and an important factor to ensure DNA replication and sister chromatid cohesion. Deletion of this protein results in severe cohesion defects, however, the function and cellular role of this ...

journal_title：Biochemical and biophysical research communications

authors： Mamnun YM,Katayama S,Toda T

更新日期：2006-11-10 00:00:00