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Targeted optical imaging of cancer cells using lectin-binding BODIPY conjugated avidin.

Abstract：

:Lectins (asialo-receptor family) are expressed on a number of tumors that develop peritoneal metastases. To demonstrate that fluorescence imaging based on lectin binding is applicable for a variety of tumors, we conjugated BODIPY to avidin (avidin-BODIPY), and studied the efficacy of tumor targeting in 9 cancer cell lines in vitro and an ovarian cancer cell line in vivo using a murine peritoneal cancer model. All 9 cell lines showed specific intracellular accumulation with avidin-BODIPY on fluorescence microscopy and flow cytometry. In vivo spectral molecular imaging clearly visualized the peritoneal tumor foci with avidin-BODIPY, whereas, deglycosylated avidin-BODIPY (neutravidin-BODIPY) showed only minimal fluorescence from the tumor foci and was accompanied by higher background signals. These results suggest the lectin-targeted molecular imaging technique using a targeted green fluorescence probe is potentially useful in a wide variety of cancers with a proclivity for dissemination in the peritoneal space.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hama Y,Urano Y,Koyama Y,Choyke PL,Kobayashi H

doi

10.1016/j.bbrc.2006.07.169

subject

Has Abstract

pub_date

2006-09-29 00:00:00

pages

807-13

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)01617-2

journal_volume

348

pub_type

杂志文章

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