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Chloroform markedly stimulates the phosphorylation of myelin basic proteins.

Abstract：

:We have investigated the effect of chloroform on the phosphorylation of myelin basic proteins because tumor-promoting agents such as phorbol esters and chloroform are known to enhance the activity of protein kinase C. We report that the presence of chloroform, at a concentration known to enhance protein kinase C activity, stimulated the phosphorylation of myelin basic proteins 15-17 fold over control conditions. The phosphorylation of a 50 kiloDalton myelin protein was also stimulated but to a lesser extent. The concentration of chloroform required for the maximal phosphorylation of myelin basic proteins and the 50 kiloDalton protein was approximately 2% (v/v).

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ulmer JB,Braun PE

doi

10.1016/0006-291x(87)90758-3

subject

Has Abstract

pub_date

1987-08-14 00:00:00

pages

1084-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90758-3

journal_volume

146

pub_type

杂志文章

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