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OGT functions as a catalytic chaperone under heat stress response: a unique defense role of OGT in hyperthermia.

Abstract：

:Protein O-GlcNAcylation is proceeded by O-linked GlcNAc transferase (OGT) in nucleocytoplasm and is involved in many biological processes although its physiological role is not clearly defined. To identify the functional significance of O-GlcNAcylation, we investigated heat stress effects on protein O-GlcNAcylation. Here, we found that protein O-GlcNAcylation was significantly increased in vivo during acute heat stress in mammalian cells and simultaneously, the enhanced protein O-GlcNAcylation was closely associated with cell survival in hyperthermia. Our results demonstrate that hyperthermal cytotoxicity may considerably be facilitated under the condition of insufficient level of protein O-GlcNAcylation inside cells. Furthermore, OGT reaction might be crucial for triggering thermotolerance to recover hyperthermal sensitivity without particular induction of heat shock proteins (hsps). Thus, we propose that OGT can respond rapidly to heat stress through the enhancement of nucleocytoplasmic protein O-GlcNAcylation for a rescue from the early phase of hyperthermal cytotoxicity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sohn KC,Lee KY,Park JE,Do SI

doi

10.1016/j.bbrc.2004.08.023

subject

Has Abstract

pub_date

2004-09-24 00:00:00

pages

1045-51

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)01751-6

journal_volume

322

pub_type

杂志文章

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