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Intracellular redox state regulation by parthenolide.

Abstract：

:In the present paper, we report a strong intracellular antioxidant activity of the sesquiterpene lactone parthenolide in the hippocampal HT22 cells. This effect is mediated by an increase of total glutathione at both, low (5 microM) and high (10 microM), concentrations. Parthenolide also increases the activation of the antioxidant/electrophile response element. This effect is the possible mediator of glutathione increase, since the limiting enzyme on its synthesis possesses this response element on its promoter. Finally, we demonstrate that its antioxidant properties do not mediate its antiproliferative effect nor its inhibition of NF-kappaB.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Herrera F,Martin V,Rodriguez-Blanco J,García-Santos G,Antolín I,Rodriguez C

doi

10.1016/j.bbrc.2005.04.131

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

321-5

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)00917-4

journal_volume

332

pub_type

杂志文章

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