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Low-level oxidative stress causes cell-cycle specific arrest in cultured cells.

Abstract：

:Oxidative stress is involved in a multitude of pathological conditions. In the present study, cell cycle arrest was demonstrated in monolayer cultures of Chinese hamster ovary cells subjected to low-level oxidative stress induced by the addition of hydrogen peroxide. Fluorescence-activated cell sorting analysis characterized this arrest as occurring in both the G1 and G2/M phases of the cell cycle. Upon exposure to oxidative stress, cells in G1 arrest in G1, while S-phase cells complete DNA synthesis and subsequently arrest in G2/M. Nitroxide spin labels with differing permeabilities are able to protect the cells, which suggests that both the G1 and the G2/M arrest involve oxidation of targets located at the cell surface.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Clopton DA,Saltman P

doi

10.1006/bbrc.1995.1645

subject

Has Abstract

pub_date

1995-05-05 00:00:00

pages

189-96

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)71645-2

journal_volume

210

pub_type

杂志文章

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