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Nerve growth factor mRNA in brain: localization by in situ hybridization.

Abstract：

:Nerve Growth Factor is a 118 amino acid polypeptide that plays an important role in the differentiation and survival of neurons. The recent discovery that a mRNA that encodes beta Nerve Growth Factor is present in brain suggests that the Nerve Growth Factor gene may not only regulate gene expression of peripheral but also of central neurons. To identify the site(s) of Nerve Growth Factor mRNA production in the brain and to determine which cells express the Nerve Growth Factor gene, the technique of in situ hybridization was employed. A 32P-labeled RNA probe complementary to Nerve Growth Factor mRNA hybridized to cells in the stratum granulosum of the dentate gyrus and the stratum pyramidale of the hippocampus. These observations identify for the first time cellular sites of Nerve Growth Factor gene expression in the central nervous system, and suggest that Nerve Growth Factor mRNA is produced by neurons.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Rennert PD,Heinrich G

doi

10.1016/s0006-291x(86)80569-1

subject

Has Abstract

pub_date

1986-07-31 00:00:00

pages

813-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(86)80569-1

journal_volume

138

pub_type

杂志文章

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