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Role of apoptosis in growth and differentiation of proximal tubule cells in primary cultures.

Abstract：

:In this study, we assessed the profile of cell proliferation, Na,K-ATPase activity and apoptosis in primary cultures of proximal tubule cells. Freshly isolated proximal tubules exhibited apoptosis very early in culture: floated cells within 6 hr; attached tubule cells within 20 hr. The onset of apoptosis in either attached or floated proximal tubules was accompanied by a decline of Na,K-ATPase activity, indicating a close relationship between apoptosis and dedifferentiation. The ratio of apoptosis was highest at the lag phase and lowest at the rapid growth phase, reflecting an inverse relationship between mitogenesis and apoptosis. Our data indicate that apoptosis is involved in the growth and early downregulation of Na,K-ATPase activity in primary cultures of proximal tubule cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tang MJ,Cheng YR,Lin HH

doi

10.1006/bbrc.1996.0118

subject

Has Abstract

pub_date

1996-01-26 00:00:00

pages

658-64

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)90118-7

journal_volume

218

pub_type

杂志文章

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