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NS5A protein of HCV enhances HBV replication and resistance to interferon response.

Abstract：

:HCV and HBV are the major causes of chronic liver diseases worldwide. Patients with both viruse's co-infection tend to develop severer liver diseases and are at high risk of liver-related death. NS5A protein of HCV plays key roles in HCV replication and inhibition of host immune responses. In this study, we described the establishment of HepG2-derived cell line that stably expresses NS5A protein and the application of a cellular system for HBV replication based on a recombinant adenovirus carrying HBV genome. Our results demonstrated that NS5A enhances the expression of S and E proteins of HBV, as well as the synthesis of viral DNA. Moreover, we showed that NS5A assists HBV to escape interferon responses. These data suggested that NS5A of HCV may employ multiple strategies contributing to the enhancement of HBV replication and interferon resistance during the co-infection of HCV and HBV.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Pan Y,Wei W,Kang L,Wang Z,Fang J,Zhu Y,Wu J

doi

10.1016/j.bbrc.2007.05.052

subject

Has Abstract

pub_date

2007-07-20 00:00:00

pages

70-5

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01006-6

journal_volume

359

pub_type

杂志文章

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