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Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I.

Abstract：

:Gene-recombinant human growth hormone (rhGH) elicited a dose-dependent stimulation of the proliferation of osteoblast-like cells (OB), when grown in strictly serum-free longterm cultures. A half-maximal effect was observed at concentrations of 15-20 ng/ml and the maximal stimulation was 160% of hormone-free controls. The rhGH-induced effect on proliferation could be inhibited dose-dependently by the addition of an insulin-like growth factor (IGF) I-antiserum to the medium. Moreover, IGF I and rhGH had additive effects only when the exogenous IGF I concentration exceeded that of endogenously produced IGF I by a large margin. Thus, direct stimulation of OB proliferation by rhGH is, at least in part, mediated by IGF I-like immunoreactivity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ernst M,Froesch ER

doi

10.1016/0006-291x(88)90570-0

subject

Has Abstract

pub_date

1988-02-29 00:00:00

pages

142-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(88)90570-0

journal_volume

151

pub_type

杂志文章

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