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The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.

Abstract：

:Bile acids have recently emerged as key metabolic hormones with beneficial impacts in multiple metabolic diseases. We previously discovered that hepatic bile acid overload distally modulates glucose and fatty acid metabolism in adipose tissues to exert anti-obesity effects. However, the detailed mechanisms that explain the salutary effects of serum bile acid elevation remain unclear. Here, proteomic profiling identified a new hepatokine, Orosomucoid (ORM) that governs liver-adipose tissue crosstalk. Hepatic ORMs were highly induced by both genetic and dietary bile acid overload. To address the direct metabolic effects of ORM, purified ORM proteins were administered during adipogenic differentiation of 3T3-L1 cells and mouse stromal vascular fibroblasts. ORM suppressed adipocyte differentiation and strongly inhibited gene expression of adipogenic transcription factors such as C/EBPβ, KLF5, C/EBPα, and PPARγ. Taken together, our data clearly suggest that bile acid-induced ORM secretion from the liver blocks adipocyte differentiation, potentially linked to anti-obesity effect of bile acids.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lee SH,Choi JM,Jung SY,Cox AR,Hartig SM,Moore DD,Kim KH

doi

10.1016/j.bbrc.2020.10.086

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

864-870

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)32015-5

journal_volume

534

pub_type

杂志文章

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