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The salvage of deoxycytidine into dCDP-diacylglycerol by macrophages and lymphocytes.

Abstract：

:Extracellular deoxycytidine (CdR) was previously shown to be salvaged into water soluble [1] and also into lipidic [2] precursors of phospholipids in stimulated lymphocytes and in lymphoma cells [3]. In this paper we have described that non-dividing murine macrophages salvaged not only 5-3H-CdR but also tritiated thymidine (3H-TdR) mainly into the pools as nucleotides. Chlorpromazine shifted the CdR salvage into a lipidic compound of the cells which was identified as 3H-dCDP-diacylglycerol (dCDP-DAG). After 5-3H-CdR labeling the lipid/DNA ratio was eleven times higher in macrophages than in tonsillar lymphocytes. Thin layer chromatography (TLC) on borate impregnated silica gel plates gave clear separation of CDP-DAG from dCDP-DAG supporting that the extracellular precursor for it is exclusively deoxycytidine and not ribocytidine. No interconversion between deoxy- and and ribocytidine could be observed neither in lymphocytes nor in macrophages.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hrabák A,Spasokukotskaja T,Temesi A,Staub M

doi

10.1006/bbrc.1993.1611

subject

Has Abstract

pub_date

1993-05-28 00:00:00

pages

212-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)71611-6

journal_volume

193

pub_type

杂志文章

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