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Antibody-induced activation of the epidermal growth factor receptor tyrosine kinase requires the presence of detergent.

Abstract：

:Activation of the epidermal growth factor receptor (EGF-R) tyrosine kinase was investigated in membrane preparations as well as intact A431 cells, using anti-EGF-R antibodies directed against extra- and intracellular receptor domains. In vitro assay conditions were mimicked on whole cells by a mild detergent treatment. We show that, irrespective of the recognition site on the EGF-R, antibodies induce EGF-R autophosphorylation and tyrosine kinase activity towards other endogenous and exogenous substrates, but only when detergent is present. We propose that the primary effect of detergent is to create conditions in the lipid environment of the EGF-R that allow antibodies to induce receptor-receptor interactions necessary for tyrosine kinase activation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Spaargaren M,Defize LH,de Laat SW,Boonstra J

doi

10.1016/0006-291x(90)91228-k

subject

Has Abstract

pub_date

1990-09-14 00:00:00

pages

882-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)91228-K

journal_volume

171

pub_type

杂志文章

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