Low density lipoprotein (LDL) inhibits histamine release from human mast cells.

abstract：:In continuation of our recent observations indicating the presence of a lone calcineurin-dependent response element (CDRE) in the -3730bp upstream region of copper-induced metallothionein (CuMT) gene of Neurospora [K.S. Kumar, S. Dayananda, C. Subramanyam, Copper alone, but not oxidative stress, induces copper-metallo...

journal_title：Biochemical and biophysical research communications

authors： Kumar KS,Ravi Kumar B,Siddavattam D,Subramanyam C

更新日期：2006-07-07 00:00:00

abstract：:We prepared a cleavage site-directed antiserum against Caspase-3 (anti-p20/17), which reacts with the p20/17 fragment (p20/17) activated by cleavage but not proCaspase-3 (p32), and examined the relationship between the activation of Caspase-3 and apoptosis. We identified p20/17-positive cells where cell death occurs n...

journal_title：Biochemical and biophysical research communications

authors： Kouroku Y,Urase K,Fujita E,Isahara K,Ohsawa Y,Uchiyama Y,Momoi MY,Momoi T

更新日期：1998-06-29 00:00:00

abstract：:The ability to prevent methylene blue (MB), a photosensitizer, from being reduced by plasma reductases will greatly improve its efficacy in photodynamic therapy (PDT) applications. We have developed a delivery approach for PDT by encapsulating MB using nanoparticle platforms (NPs). The 30-nm polyacrylamide-based NPs p...

journal_title：Biochemical and biophysical research communications

authors： Tang W,Xu H,Park EJ,Philbert MA,Kopelman R

更新日期：2008-05-02 00:00:00

abstract：:We have isolated calpromotin, a protein reported abundant in human red cells and shown to be of significance for KCl transport. We show that calpromotin is identical to a radical scavenger protein, thiol-specific antioxidant protein (TSA). Calpromotin is known to exist partially as a large complex of identical subunit...

journal_title：Biochemical and biophysical research communications

authors： Kristensen P,Rasmussen DE,Kristensen BI

更新日期：1999-08-19 00:00:00

abstract：:This investigation of Ca2+ requirements for the mitogenic activation of lymphocytes by periodic acid has shown that oxidation by periodate causes an immediate and transient increase of Ca2+ influx and efflux in oxidized cells. Oxidized lymphocytes maintained in the medium containing 0.2 mM Ca2+ failed to proliferate o...

journal_title：Biochemical and biophysical research communications

authors： Hornicek FJ,Malinin GI,Malinin TI

更新日期：1992-02-28 00:00:00

abstract：:Our previous study indicates that hyperinsulinemia in metabolic syndrome in the absence of nephropathy may promote hypertension by stimulating renal proximal tubule (PT) sodium transport via insulin receptor substrate (IRS) 2/phosphoinositide 3-kinase pathway. In the present study we showed that the stimulatory effect...

journal_title：Biochemical and biophysical research communications

authors： Nakamura M,Satoh N,Suzuki M,Kume H,Homma Y,Seki G,Horita S

更新日期：2015-05-22 00:00:00

abstract：:Hyaluronan synthase 2 (HAS2) is an integral membrane protein composed of multi-membrane-spanning regions and a large intracellular loop (HAS2-loop). We previously examined the effect of phorbol 12-myristate 13-acetate (PMA) and/or 4-methylumbelliferone (4-MU) on the synthesis of hyaluronan (HA) in human skin fibroblas...

journal_title：Biochemical and biophysical research communications

authors： Kasai K,Kuroda Y,Takabuchi Y,Nitta A,Kobayashi T,Nozaka H,Miura T,Nakamura T

更新日期：2020-12-17 00:00:00

abstract：:DC-SIGN, a C-type lectin receptor expressed in dendritic cells (DCs), has been identified as a receptor for human immunodeficiency virus type 1, hepatitis C virus, Ebola virus, cytomegalovirus, dengue virus, and the SARS coronavirus. We used H5N1 pseudotyped and reverse-genetics (RG) virus particles to study their abi...

journal_title：Biochemical and biophysical research communications

authors： Wang SF,Huang JC,Lee YM,Liu SJ,Chan YJ,Chau YP,Chong P,Chen YM

更新日期：2008-09-05 00:00:00

abstract：:A rabbit cytochrome P-450IIE2 full-length cDNA was cloned into a yeast episomal plasmid (YEp13) between the copper-responsive yeast metallothionein gene promoter (CUP1) and the iso-1-cytochrome c gene terminator (CYC1), and the cytochrome P-450 was expressed in Saccharomyces cerevisiae. The microsomal fraction prepare...

journal_title：Biochemical and biophysical research communications

authors： Pernecky SJ,Porter TD,Coon MJ

更新日期：1990-11-15 00:00:00

abstract：:Starch branching enzyme (SBE) catalyzes the cleavage of α-1,4-linkages and the subsequent transfer of α-1,4 glucan to form an α-1,6 branch point in amylopectin. We determined the crystal structure of the rice branching enzyme I (BEI) in complex with maltopentaose at a resolution of 2.2Å. Maltopentaose bound to a hydro...

journal_title：Biochemical and biophysical research communications

authors： Chaen K,Noguchi J,Omori T,Kakuta Y,Kimura M

更新日期：2012-08-03 00:00:00

abstract：:Earlier investigations have shown that (a) antibodies against a carrier-coupled 20-residue synthetic peptide (C-20), (200)HACQKKLLKFEALQQEEGEE(219), corresponding to the C-terminal partially helical sequence of chicken riboflavin carrier protein (RCP; 219 AA) curtail pregnancy in mammals and (b) helix stabilization by...

journal_title：Biochemical and biophysical research communications

authors： Subramanian S,Karande AA,Adiga PR

更新日期：2001-09-14 00:00:00

abstract：:Hypothesis of non-enzymatic recognition of primordial tRNA and mRNA precursors is experimentally approached. DNA hairpins containing a different number of deoxyguanosine residues in the loop are analyzed for their binding ability to a chemically fixed single-strand of oligo(dC). In presence of small Mg2+ concentration...

journal_title：Biochemical and biophysical research communications

authors： Baumann U,Frank R,Blöcker H

更新日期：1988-12-30 00:00:00

abstract：:Neurotrophins are essential for the development and survival of catecholaminergic neurons. However, the critical pathway for expression of the tyrosine hydroxylase (TH) gene induced by neurotrophin is still unclear. Here we found that Ras/MEK pathway is required for NGF-induced expression of the TH gene in PC12D cells...

journal_title：Biochemical and biophysical research communications

authors： Suzuki T,Kurahashi H,Ichinose H

更新日期：2004-03-05 00:00:00

abstract：:We have demonstrated the existence of two distinct subtypes of the angiotensin II receptor in the rat adrenal gland using radioligand binding and tissue section autoradiography. The identification of the subtypes was made possible by the discovery of two structurally dissimilar, nonpeptide compounds, DuP 753 and EXP65...

journal_title：Biochemical and biophysical research communications

authors： Chiu AT,Herblin WF,McCall DE,Ardecky RJ,Carini DJ,Duncia JV,Pease LJ,Wong PC,Wexler RR,Johnson AL

更新日期：1989-11-30 00:00:00

abstract：:Telomeres, specialized domains assembled at the ends of linear chromosomes, are essential for genomic stability in eukaryotes. The formation and maintenance of telomeres are governed by numerous factors such as telomeric repeats, telomere-binding proteins, heterochromatin proteins, and telomerase. Here, we report Sde2...

journal_title：Biochemical and biophysical research communications

authors： Sugioka-Sugiyama R,Sugiyama T

更新日期：2011-03-18 00:00:00

abstract：:Staurosporine (STAR), a potent protein kinase C (PKC) antagonist, was found to modulate the chemoattractant-induced respiratory burst of human polymorphonuclear leukocytes (PMNs) according to drug concentration. Low STAR concentrations from 10 to 200 nM potentiated the N-formyl-methionyl-leucyl-phenylalanine (fMLP) an...

journal_title：Biochemical and biophysical research communications

authors： Combadière C,Hakim J,Giroud JP,Périanin A

更新日期：1990-04-16 00:00:00

abstract：:Hydrogen peroxide, tert-butyl hydroperoxide, cumene hydroperoxide, and 3-chloroperoxybenzoic acid (CPB) and 15-HPETE relaxed, in a concentration dependent manner rat aortic rings contracted with PGF2 alpha (1 X 10(-5)). Relaxation is not inhibited by either indomethacin (2 X 10(-5) M), a cyclo-oxygenase inhibitor or e...

journal_title：Biochemical and biophysical research communications

authors： Thomas G,Ramwell P

更新日期：1986-08-29 00:00:00

abstract：:Lysenin, a hemolytic protein derived from the body fluid of earthworm, was incorporated into artificial bilayer membranes. Upon insertion, it formed a voltage-dependent large conductance channel in asolectin bilayers in a sphingomyelin-dependent manner. The channel had low ion-selectivity. Single-channel conductance w...

journal_title：Biochemical and biophysical research communications

authors： Ide T,Aoki T,Takeuchi Y,Yanagida T

更新日期：2006-07-21 00:00:00

abstract：:A Balb/c mouse was immunized with chick synaptic plasma membranes and monoclonal antibodies were produced by fusion of spleen cells with NS-1 mouse myeloma cells. One antibody, MAC-L1, immunoprecipitated more than 90% of the [3H]PN200-110-labeled calcium channels but only 20% of the omega -conotoxin receptor solubiliz...

journal_title：Biochemical and biophysical research communications

authors： Takahashi M,Fujimoto Y

更新日期：1989-09-15 00:00:00

abstract：:The ras family of oncogenes, as well as the transplasma membrane electron transport system, have been implicated in cellular growth control. Here we present evidence that the Ha-ras oncoprotein increases the activity of the transplasma membrane electron transport system in the mouse embryonic fibroblast cell line C3H1...

journal_title：Biochemical and biophysical research communications

authors： Crowe RA,Taparowsky EJ,Crane FL

更新日期：1993-10-29 00:00:00

abstract：:The human poly(rC)-binding protein (PCBP) 2 is known to interact with enteroviral RNA. Here, the interaction of PCBP2 with RNA target sequences at the 5' end of the coxsackievirus B3 genome was investigated. Using the electrophoretic mobility shift assay and the yeast three-hybrid system, a short oligo(rC) tract conne...

journal_title：Biochemical and biophysical research communications

authors： Zell R,Ihle Y,Seitz S,Gündel U,Wutzler P,Görlach M

更新日期：2008-02-22 00:00:00

abstract：:Upon N-demethylation of caffeine (CA) by rat and human liver microsomes, theobromine (TB), paraxanthine (PX), and theophylline (TP) are produced. The optimal pHs for the formation of TB, PX, and TP from CA by rat liver microsomes are 7.4 (most), 8.2 (minor) and 8.6 (moderate). At pH 7.4, PX is the primary metabolite f...

journal_title：Biochemical and biophysical research communications

authors： Chung WG,Cha YN

更新日期：1997-06-27 00:00:00

abstract：:In order to establish a working cellular model for the study of post-receptor signaling events, insulin-dependent phosphatidylinositol 3' (PtdIns 3')-kinase activity was investigated in circulating mononuclear cells from normal subjects. The p85 alpha regulatory subunit of PtdIns 3'-kinase co-precipitated with activat...

journal_title：Biochemical and biophysical research communications

authors： Renard E,Grigorescu F,Lavabre C,Kahn CR

更新日期：1995-04-06 00:00:00

abstract：:Tubby domain superfamily protein (TUSP) is a distant member of the Tubby-like protein (TULP) family. Although other TULPs play important roles in sensation, metabolism, and development, the molecular functions of TUSP are completely unknown. Here, we explore the function of TUSP in the Drosophila nervous system where ...

journal_title：Biochemical and biophysical research communications

authors： Yoon EJ,Jeong YT,Lee JE,Moon SJ,Kim CH

更新日期：2017-01-22 00:00:00

abstract：:NEMO is an essential regulatory component of the IkappaB kinase (IKK) complex, which controls activation of the NF-kappaB signaling pathway. Herein, we show that NEMO exists as a disulfide-bonded dimer when isolated from several cell types and analyzed by SDS-polyacrylamide gel electrophoresis under non-reducing condi...

journal_title：Biochemical and biophysical research communications

authors： Herscovitch M,Comb W,Ennis T,Coleman K,Yong S,Armstead B,Kalaitzidis D,Chandani S,Gilmore TD

更新日期：2008-02-29 00:00:00

abstract：:An organic extract of Nitzschia alba cells possesses ionophoretic activity towards silicate, as it induces silicate transport across an organic phase or across synthetic lipid membranes. The activity is dependent upon Na+ and prefers silicon to germanium, a congener. The activity can be resolved into two apparently pu...

journal_title：Biochemical and biophysical research communications

authors： Bhattacharyya P,Volcani BE

更新日期：1983-07-18 00:00:00

abstract：:Inhibitors of poly(ADP-ribose) synthetase, namely nicotinamide, benzamide, m-methoxybenzamide and 3-aminobenzamide, augmented chondrocytic differentiation chick embryo limb bud mesenchymal cells, in culture. These inhibitors stimulated early appearance and massive formation of cartilage nodules in micromass cultures s...

journal_title：Biochemical and biophysical research communications

authors： Nishio A,Nakanishi S,Doull J,Uyeki EM

更新日期：1983-03-16 00:00:00

abstract：:Insulin-like growth factor-II (IGF-II) is a potent mitogen for cells in culture. The H19 gene is a developmentally regulated gene with putative tumor suppressor activity, and loss of H19 expression may be involved in tumorigenesis. The H19 gene is closely linked to the human IGF-II gene (IGF2) on chromosome 11p15.5 an...

journal_title：Biochemical and biophysical research communications

authors： Kiess W,Paquette J,Koepf G,Wolf E,Deal C

更新日期：1999-02-16 00:00:00

abstract：:A mitochondrial DNA mutation at nucleotide position 14,484 was found in 14 independent probands with Leber hereditary optic neuropathy and in 0/250 controls. The 14,484 mutation, which changes methionine-64 to valine in a conserved domain of the ND-6 gene, occurred in association with a mitochondrial DNA haplotype tha...

journal_title：Biochemical and biophysical research communications

authors： Johns DR,Neufeld MJ,Park RD

更新日期：1992-09-30 00:00:00

abstract：:Mutations in the Treacher Collins syndrome gene, TCOF1, cause a disorder of craniofacial development. We manipulated the levels of Tcof1 and its protein treacle in a murine neuroblastoma cell line to identify downstream changes in gene expression using a microarray platform. We identified a set of genes that have simi...

journal_title：Biochemical and biophysical research communications

authors： Mogass M,York TP,Li L,Rujirabanjerd S,Shiang R

更新日期：2004-12-03 00:00:00