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The cytotoxic eosinophil cationic protein (ECP) has ribonuclease activity.

Abstract：

:The eosinophil cationic protein (ECP) is a specific cytotoxic constituent of granules. In this work we demonstrated that ECP has a ribonuclease activity. Purified ECP was resolved by ion exchange chromatography into subfractions, which all showed ribonuclease activity. Another eosinophil granule protein, EPX, identical with eosinophil-derived neurotoxin (EDN) had a 125-fold higher RNase activity than ECP. ECP may exert its cytotoxic effects on parasites and cells because of its extreme basicity alone or it may be internalized and act by degrading mRNA.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Gullberg U,Widegren B,Arnason U,Egesten A,Olsson I

doi

10.1016/s0006-291x(86)80310-2

subject

Has Abstract

pub_date

1986-09-30 00:00:00

pages

1239-42

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(86)80310-2

journal_volume

139

pub_type

杂志文章

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