当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers.

Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers.

Abstract：

:The family of G-protein-activated inward-rectifiers K+ channels presently comprise at least 3 cloned members called GIRK1, GIRK2 and GIRK3. A close structural parent of GIRK channels has recently been described as being an ATP-sensitive K+ channel. This paper shows that Xenopus expression of this new channel that we call GIRK4 does not produce an ATP-inhibitable activity with a pharmacological activation by pinacidil as previously described but instead a G-protein activated inward-rectifier. While oocyte expression of single subunits is infrequent and relatively modest in intensity, expression of GIRK1,2, GIRK1,4 and GIRK2,4 mixtures leads to routine and robust expression of K+ channels indicating that heterologous subunit assembly is necessary for activity. Activity of GIRK1,2, GIRK1,4 and GIRK2,4 channels required the presence of ATP acting as an activator at the cytoplasmic face and is further activated by the beta gamma subunits.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Duprat F,Lesage F,Guillemare E,Fink M,Hugnot JP,Bigay J,Lazdunski M,Romey G,Barhanin J

doi

10.1006/bbrc.1995.2019

subject

Has Abstract

pub_date

1995-07-17 00:00:00

pages

657-63

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)72019-0

journal_volume

212

pub_type

杂志文章

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