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Concanavalin A can trap insulin and increase insulin internalization into cells cultured in monolayer.

Abstract：

:When rat hepatoma cells (R-Y121B) were incubated with insulin at 37 degrees C, concanavalin A increased insulin internalization into cells. When R-Y121B cells were first incubated with labeled insulin at 4 degrees C then with concanavalin A at various concentrations at 37 degrees C, the total cellular radioactivity was much higher at high lectin concentrations than at low lectin concentrations. This increase was not only due to an increase in insulin internalization into cells but also to an increase in insulin binding to cell surfaces. Concanavalin A can trap insulin on the insulin receptors - a "trapping" effect. It has been concluded that insulin and concanavalin A binding sites are very close to each other on the insulin receptors.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sorimachi K,Yasumura Y

doi

10.1016/0006-291x(84)90460-1

subject

Has Abstract

pub_date

1984-07-18 00:00:00

pages

204-11

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(84)90460-1

journal_volume

122

pub_type

杂志文章

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