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Tubby domain superfamily protein is required for the formation of the 7S SNARE complex in Drosophila.

Abstract：

:Tubby domain superfamily protein (TUSP) is a distant member of the Tubby-like protein (TULP) family. Although other TULPs play important roles in sensation, metabolism, and development, the molecular functions of TUSP are completely unknown. Here, we explore the function of TUSP in the Drosophila nervous system where it is expressed in all neurons. Tusp mutant flies exhibit a temperature-sensitive paralysis. This paralysis can be rescued by tissue-specific expression of Tusp in the giant fibers and peripherally synapsing interneurons of the giant fiber system, a well-characterized neuronal circuit that mediates rapid escape behavior in flies. Consistent with this paralytic phenotype, we observed a profound reduction in the assembly of the ternary 7S SNARE complex that is required for neurotransmitter release despite seeing no changes in the expression of each individual SNARE complex component. Together, these data suggest TUSP is a novel regulator of SNARE assembly and, therefore, of neurotransmitter release.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yoon EJ,Jeong YT,Lee JE,Moon SJ,Kim CH

doi

10.1016/j.bbrc.2016.11.117

subject

Has Abstract

pub_date

2017-01-22 00:00:00

pages

814-820

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(16)31991-X

journal_volume

482

pub_type

杂志文章

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