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A novel protein kinase activity in rabbit gastric gland cytosol.

Abstract：

:A novel protein kinase activity was characterized from the cytosolic fraction of isolated rabbit gastric glands. The kinase phosphorylated a major 33,000 Da endogenous protein (pp33) and was stimulated by Zn2+ and Mn2+ with Kact of 1.0 and 7.5 mM, respectively. Mg2+ and Ca2+ failed to stimulate any pp33 kinase activity. The kinase utilized both ATP and GTP as phosphate donors with a Km of 10 microM for both. The pp33 protein displayed an isoelectric point of 7.5 to 7.8 and was phosphorylated predominantly on threonine residues. The kinase activity is clearly differentiable from all reported kinase activities and appeared to be enriched in rabbit gastric fundic mucosa. The results indicate that gastric fundic mucosa contains a novel protein kinase activity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Goldenring JR,Oddsdottir M,Modlin IM

doi

10.1016/0006-291x(87)90310-x

subject

Has Abstract

pub_date

1987-01-30 00:00:00

pages

559-66

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90310-X

journal_volume

142

pub_type

杂志文章

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