Corticotropin-releasing factor stimulates Ca2+ influx in cultured rat astrocytes.

abstract：:Internal backbone dynamic motions are essential for different protein functions and occur on a wide range of time scales, from femtoseconds to seconds. Molecular dynamic (MD) simulations and nuclear magnetic resonance (NMR) spin relaxation measurements are valuable tools to gain access to fast (nanosecond) internal mo...

journal_title：Biochemical and biophysical research communications

authors： Liu Q,Shi C,Yu L,Zhang L,Xiong Y,Tian C

更新日期：2015-02-13 00:00:00

abstract：:We previously found that p53 binds to the catalytic subunit of the p34(cdc2)/cyclin B1-kinase. In the present study we analyzed the functional consequences of this interaction. Binding of wild-type p53 to p34(cdc2)/cyclin B1 results in a significant decrease of its histone H1 kinase activity. Binding of p53 to the kin...

journal_title：Biochemical and biophysical research communications

authors： Ababneh M,Götz C,Montenarh M

更新日期：2001-05-04 00:00:00

abstract：:We have used electron paramagnetic resonance (EPR) to examine the structural impact of oxidizing specific methionine (M) side chains in calmodulin (CaM). It has been shown that oxidation of either M109 or M124 in CaM diminishes CaM regulation of the muscle calcium release channel, the ryanodine receptor (RyR), and tha...

journal_title：Biochemical and biophysical research communications

authors： McCarthy MR,Thompson AR,Nitu F,Moen RJ,Olenek MJ,Klein JC,Thomas DD

更新日期：2015-01-09 00:00:00

abstract：:Cysteinyl leukotrienes (cysLTs), which include leukotriene C4 (LTC4), are the predominant class of LTs synthesized by mast cells. CysLTs can induce many of the abnormalities seen in asthma. LTC4 is generated by the conjugation of LTA4 with reduced glutathione (GSH) by LTC4 synthase. During screening of the effects of ...

journal_title：Biochemical and biophysical research communications

authors： Seki K,Hisada T,Kawata T,Kamide Y,Dobashi K,Yamada M,Mori M,Okajima F,Ishizuka T

更新日期：2013-09-27 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Today, AD can be diagnosed with certainty only post-mortem, by histopathologic staining of Abeta plaques and neurofibrillary tangles in brain tissue sections. We have developed an ultra-sensitive assay potential...

journal_title：Biochemical and biophysical research communications

authors： Funke SA,Birkmann E,Henke F,Görtz P,Lange-Asschenfeldt C,Riesner D,Willbold D

更新日期：2007-12-28 00:00:00

abstract：:An amino acid substitution of Met for Val at position 30 of plasma prealbumin is known to be closely related to heredo-familial amyloidotic polyneuropathy(FAP). As a first step in development of a direct method for diagnosis of the disease, cDNA for normal human prealbumin was cloned and its nucleotide sequence was de...

journal_title：Biochemical and biophysical research communications

authors： Sasaki H,Sakaki Y,Matsuo H,Goto I,Kuroiwa Y,Sahashi I,Takahashi A,Shinoda T,Isobe T,Takagi Y

更新日期：1984-12-14 00:00:00

abstract：:The catalytic and immunological properties of acid phosphatases (EC 3.1.3.2.) in different tissues were studied. It was demonstrated that high uptake forms of lysosomal enzymes like beta-galactosidase isolated from human platelets and bovine testis are mature enzymes, which have not lost their mannose-6phosphate marke...

journal_title：Biochemical and biophysical research communications

authors： Hu P,Parenti G,Keulemans J,Hoogeveen AT

更新日期：1990-03-16 00:00:00

abstract：:Highly purified bovine heart protein phosphatase 2A catalytic subunit lost virtually all of its activity during storage at -70 degrees. When the enzyme was preincubated with Co2+, over 35% of the original activity was restored. Freshly prepared protein phosphatase 2A purified from bovine heart was stimulated at least ...

journal_title：Biochemical and biophysical research communications

authors： Cai L,Chu Y,Wilson SE,Schlender KK

更新日期：1995-03-08 00:00:00

abstract：:Mammary epithelial cells derived from the entire mammary parenchyma or only end buds were isolated by collagenase digestion of mammary glands from virgin mice. Cells were cultured within collagen gels in serum-free medium containing insulin. Keratinocyte growth factor (KGF or FGF-7) and acidic fibroblast growth factor...

journal_title：Biochemical and biophysical research communications

authors： Imagawa W,Cunha GR,Young P,Nandi S

更新日期：1994-11-15 00:00:00

abstract：:Using both a 25 mM Lithium di-iodosalicylic acid (LIS) and a 2M NaCl extraction procedure to extract nuclear matrices from white cells we have identified a 0.9 kb nuclear matrix associated region (MAR) in the human pro alpha 2(I) collagen gene. The MAR is located towards the 3' coding end of the gene, it is completely...

journal_title：Biochemical and biophysical research communications

authors： Ellis GC,Grobler-Rabie AF,Hough FS,Bester AJ

更新日期：1988-12-15 00:00:00

abstract：:The stromal cell-derived factor-1α/C-X-C chemokine receptor 4 (SDF-1/CXCR4) axis is involved in various aspects of tissue repair, regeneration and development. However, the role of SDF-1/CXCR4 in acute lung injury (ALI) remains largely unknown. The aim of the present investigation is to examine pathological changes in...

journal_title：Biochemical and biophysical research communications

authors： Guo W,Li Z,Xie X,Tan T,Wang S,Xie N,Fu M,Zhu H,Qin T

更新日期：2014-09-12 00:00:00

abstract：:Adriamycin was used in situ, in isolated liver mitochondria of hyperthyroid rats to study the role of cardiolipin in the functioning of FAD-linked L-glycerol-3-phosphate dehydrogenase. The apparent kinetic parameters of the reaction catalyzed by the enzyme were affected by adriamycin. The effect of adriamycin was depe...

journal_title：Biochemical and biophysical research communications

authors： Beleznai Z,Jancsik V

更新日期：1989-02-28 00:00:00

abstract：:Differences in insulin-like growth factor binding proteins (IGFBPs) expressed within estrogen receptor positive (ER+, MCF-7/6) and negative (ER-, MDA-MB-231) human breast cancer cells cultured in chemically defined medium were observed. In the absence of insulin, 17 beta-estradiol affects this expression in ER+ cells ...

journal_title：Biochemical and biophysical research communications

authors： Dubois V,Couissi D,Schonne E,Schneider YJ,Remacle C,Trouet A

更新日期：1993-04-15 00:00:00

abstract：:The octaheme cytochrome c3 (Mr 26000) from Desulfovibrio desulfuricans Norway was studied using cyclic voltammetry at the pyrolytic graphite electrode. The kinetics of reduction of the octaheme cytochrome c3 (Mr 26000) from D. desulfuricans Norway by the Ni-Fe-Se hydrogenase purified from the same organism was investi...

journal_title：Biochemical and biophysical research communications

authors： Haladjian J,Bianco P,Guerlesquin F,Bruschi M

更新日期：1991-08-30 00:00:00

abstract：:Human thymidine phosphorylase (dThdPase) is thought to be identical to an angiogenesis factor, platelet-derived endothelial cell growth factor (PD-ECGF). However, the whole amino acid sequence of dThdPase is still unknown. N-terminal amino acid sequencing of dThdPase isolated from human placenta gave the sequence Ac-A...

journal_title：Biochemical and biophysical research communications

authors： Miyadera K,Dohmae N,Takio K,Sumizawa T,Haraguchi M,Furukawa T,Yamada Y,Akiyama S

更新日期：1995-07-26 00:00:00

abstract：:A polymerizable gel superaggregate has been formed from low concentrations (6 mM) of phospholipid mixtures of polymerizable 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine and 1,2-bis(dinonoyl)-sn-glycero-3-phosphocholine. Transmission electron microscopy (TEM) revealed that the superaggregate structure con...

journal_title：Biochemical and biophysical research communications

authors： Markowitz MA,Singh A,Chang EL

更新日期：1994-08-30 00:00:00

abstract：:The 3' untranslated region (UTR) of the hepatitis C virus (HCV) is believed to function in the initiation and regulation of viral RNA replication and protein translation by interacting with the viral and host components. To examine host proteins interacting with the HCV 3'UTR, biotinylated 3'(+)UTR, and its reverse co...

journal_title：Biochemical and biophysical research communications

authors： Tingting P,Caiyun F,Zhigang Y,Pengyuan Y,Zhenghong Y

更新日期：2006-09-01 00:00:00

abstract：:We have recently reported that Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion, unveiling the first underlying mechanism of a linker protein required for maintenance of centrosome cohesion. The minichromosome maintenance (MCM) proteins 2-7 have long been noticed to lo...

journal_title：Biochemical and biophysical research communications

authors： Kong L,Yin H,Yuan L

更新日期：2017-08-05 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that are emerging as important post-transcriptional gene regulators. miR-206 is unique in that it is expressed only in skeletal muscle, including the myoblastic C2C12 cell line. In C2C12 cells, miR-206 expression was reduced dramatically after bone morphogenetic protein (BM...

journal_title：Biochemical and biophysical research communications

authors： Sato MM,Nashimoto M,Katagiri T,Yawaka Y,Tamura M

更新日期：2009-05-22 00:00:00

abstract：:Although proteins are generally composed of l-alpha-amino acids, biologically uncommon D-beta-aspartic acid (Asp)-containing proteins have been reported in various tissues from elderly individuals. Our previous study indicated that the N/N1003A cell line, derived from rabbit lens, includes D-beta-Asp-containing protei...

journal_title：Biochemical and biophysical research communications

authors： Takata T,Shimo-Oka T,Miki K,Fujii N

更新日期：2005-09-09 00:00:00

abstract：:In adrenalectomized rats, diacylglycerol, a potent activator of protein kinase C, specifically enhanced the induction of tyrosine aminotransferase and ornithine decarboxylase by even maximally effective doses of dexamethasone phosphate, but itself had no effect on these enzyme inductions in the absence of glucocortico...

journal_title：Biochemical and biophysical research communications

authors： Kido H,Fukusen N,Ishidoh K,Katunuma N

更新日期：1986-07-16 00:00:00

abstract：:Deregulation of the expression of human papillomavirus (HPV) oncogenes E6 and E7 plays a pivotal role in cervical carcinogenesis because the E6 and E7 proteins neutralize p53 and Rb tumor suppressor pathways, respectively. In approximately 90% of all cervical carcinomas, HPVs are found to be integrated into the host g...

journal_title：Biochemical and biophysical research communications

authors： Lee K,Lee AY,Kwon YK,Kwon H

更新日期：2011-08-26 00:00:00

abstract：:Migration of surviving kidney tubule cells after sub-lethal injury, for example ischemia/reperfusion (I/R), plays a critical role in recovery. Exocytosis is known to be involved in cell migration, and a key component in exocytosis is the highly-conserved eight-protein exocyst complex. We investigated the expression of...

journal_title：Biochemical and biophysical research communications

authors： Noh MR,Jang HS,Song DK,Lee SR,Lipschutz JH,Park KM,Kim JI

更新日期：2018-02-05 00:00:00

abstract：:Hepatitis delta virus (HDV) is a human pathogen causing fulminant hepatitis and liver cirrhosis. HDV has a circular single-stranded RNA genome, which encodes only a single protein, hepatitis delta antigen (HDAg), from the antigenomic strand. Although the functional roles of HDAg have been extensively studied, the mole...

journal_title：Biochemical and biophysical research communications

authors： Hwang SB,Park KJ,Kim YS

更新日期：1998-03-27 00:00:00

abstract：BACKGROUND:Statins have been reported to have anti-carcinogenic properties in addition to their cholesterol-lowering effects, but the mechanism is unknown. Thioredoxin reductases (TrxR) are selenium-containing enzymes of great importance for carcinogenesis and their levels are increased in neoplastic cells. The aim of ...

journal_title：Biochemical and biophysical research communications

authors： Skogastierna C,Johansson M,Parini P,Eriksson M,Eriksson LC,Ekström L,Björkhem-Bergman L

更新日期：2012-01-20 00:00:00

abstract：:Extracellular acidic pH-activated chloride channel I(Cl, acid), has been characterized in HEK 293 cells and mammalian cardiac myocytes. This study was designed to characterize I(Cl,acid) in human umbilical vein endothelial cells(HUVECs). The activation and deactivation of the current rapidly and repeatedly follows the...

journal_title：Biochemical and biophysical research communications

authors： Ma ZY,Zhang W,Chen L,Wang R,Kan XH,Sun GZ,Liu CX,Li L,Zhang Y

更新日期：2008-07-04 00:00:00

abstract：:Tankyrases (TNKS and TNKS2) are members of poly(ADP-ribose) polymerase (PARP) family proteins. Tankyrase has multiple ankyrin repeat cluster (ARC) domains, which recognize the tankyrase-binding motifs in proteins including the telomeric protein, TRF1 and Wnt signal regulators, AXINs. However, the functional significan...

journal_title：Biochemical and biophysical research communications

authors： Mizutani A,Seimiya H

更新日期：2020-02-19 00:00:00

abstract：:Runt-related transcription factor 2 (Runx2), also known as core binding factor 1 (Cbfa1), is a multifunctional transcription factor and an essential master gene controlling osteoblast differentiation. We previously demonstrated the in vivo functions of Runx2 in mesoderm-derived cells. However, no studies have been con...

journal_title：Biochemical and biophysical research communications

authors： Shirai Y,Kawabe K,Tosa I,Tsukamoto S,Yamada D,Takarada T

更新日期：2019-02-19 00:00:00

abstract：:The bacterial toxin Shiga toxin (Stx) is transported retrogradely from early endosomes to the Golgi apparatus on its way to the endoplasmic reticulum (ER) and the cytosol. In this study we explored the functions of the two phosphoinositide binding proteins Sorting nexin 1 (SNX1) and Sorting nexin 2 (SNX2) in endosomal...

journal_title：Biochemical and biophysical research communications

authors： Utskarpen A,Slagsvold HH,Dyve AB,Skånland SS,Sandvig K

更新日期：2007-06-29 00:00:00

abstract：:Infection with the highly pathogenic avian influenza H5N1 virus results in a high incidence of mortality in humans. Severe complications from infection are often associated with hypercytokinemia. However, current neuraminidase inhibitors (NAIs) have several limitations including the appearance of oseltamivir-resistant...

journal_title：Biochemical and biophysical research communications

authors： Cho J,Yi H,Jang EY,Lee MS,Lee JY,Kang C,Lee CH,Kim K

更新日期：2017-12-09 00:00:00