Statins inhibit expression of thioredoxin reductase 1 in rat and human liver and reduce tumour development.

abstract：:The mechanism(s) involved in the generation of free radicals in human leukocytes by phorbol myristate acetate (PMA), formyl-methionyl-leucyl-phenylalanine (FMP), lipopolysaccharide (LPS), arachidonic acid (AA), and recombinant-tumor necrosis factor-1-alpha (r-TNF-1 alpha) was investigated. Calmodulin antagonists, chlo...

journal_title：Biochemical and biophysical research communications

authors： Das UN,Padma M,Sagar PS,Ramesh G,Koratkar R

更新日期：1990-03-30 00:00:00

abstract：:The target tissues of TCDD, the dysfunctions that result in death in experimental animals, and the ultimate biochemical lesion(s) caused by TCDD are not known despite numerous studies. We have shown by the thiobarbituric acid and conjugated diene methods that TCDD induces hepatic lipid peroxidation in rats. The lipid ...

journal_title：Biochemical and biophysical research communications

authors： Stohs SJ,Hassan MQ,Murray WJ

更新日期：1983-03-29 00:00:00

abstract：:The pluripotency of embryonic stem cells (ESCs) is maintained by core pluripotency transcription factors, cofactors and several signaling pathways. RBM14 is a component of the para-speckle complex, which has been implicated in multiple important biological processes. The role of RBM14 in ESCs and lineage differentiati...

journal_title：Biochemical and biophysical research communications

authors： Chen G,Zhang D,Zhang L,Feng G,Zhang B,Wu Y,Li W,Zhang Y,Hu B

更新日期：2018-06-18 00:00:00

abstract：:In a chicken B cell line, DT40, the disruption of HDAC2 (chHDAC2) gene causes an alteration of several gene expressions including chicken IgM light chain (chIgM-L) gene by 2D-PAGE analysis. To investigate the transcriptional function of chHDAC2, we employed the chIgM-L promoter reporter plasmid. We found that chHDAC2 ...

journal_title：Biochemical and biophysical research communications

authors： Takechi S,Adachi M,Nakayama T

更新日期：2002-11-29 00:00:00

abstract：:Norepinephrine (NE) modulates brain functions depending on both the internal and external environment. While the neuromodulatory actions of NE have been well characterized, the response and involvement of cortical astrocytes to physiological noradrenergic systems remain largely unknown, especially at the molecular lev...

journal_title：Biochemical and biophysical research communications

authors： Nuriya M,Morita A,Shinotsuka T,Yamada T,Yasui M

更新日期：2018-10-12 00:00:00

abstract：:In the assay of glutamate and gamma-aminobutyric acid (GABA) with a high-performance liquid chromatography, spontaneous release of glutamate and GABA from rat hippocampal slices was significantly enhanced by mecamylamine, an inhibitor of non-alpha7 ACh receptors, or alpha-bungarotoxin, an inhibitor of alpha7 ACh recep...

journal_title：Biochemical and biophysical research communications

authors： Kanno T,Yaguchi T,Yamamoto S,Nagata T,Yamamoto H,Fujikawa H,Nishizaki T

更新日期：2005-12-16 00:00:00

abstract：:Macroautophagy is a conserved degradative pathway and its deterioration is linked to disturbances in cellular proteostasis and multiple diseases. Here, we show that the RAB GTPase RAB18 modulates autophagy in primary human fibroblasts. The knockdown of RAB18 results in a decreased autophagic activity, while its overex...

journal_title：Biochemical and biophysical research communications

authors： Feldmann A,Bekbulat F,Huesmann H,Ulbrich S,Tatzelt J,Behl C,Kern A

更新日期：2017-05-06 00:00:00

abstract：:Cartilage-derived growth factors, enhance proteoglycan synthesis in cultured chick-embryo chondrocytes, and have almost no effect on cell proliferation. Addition of cartilage derived growth factors to cartilage cells loaded with the fluorescent Ca2+ indicator quin 2, caused a rapid, concentration dependent decrease in...

journal_title：Biochemical and biophysical research communications

authors： Eilam Y,Beit-Or A,Nevo Z

更新日期：1985-10-30 00:00:00

abstract：:Lanosterol was converted to a 14-demethylated metabolite, 4,4-dimethylzymosterol by Saccharomyces cerevisiae microsomes. This metabolism was mediated by a cytochrome P-450 (P-450/14DM). However, a reconstituted system consisting of P-450/14DM and its reductase converted lanosterol to the 14-desaturated derivative of 4...

journal_title：Biochemical and biophysical research communications

authors： Aoyama Y,Yoshida Y

更新日期：1986-01-29 00:00:00

abstract：:The synthetic-peptide strategy was used to generate antibodies raised against calcium-dependent lectins of vertebrates. We demonstrate that a synthetic peptide predicted from the amino acid sequence of the carbohydrate recognition domain can induce blocking antibodies which would react with, or in close vicinity of, t...

journal_title：Biochemical and biophysical research communications

authors： Blanck O,Thibault V,Granier C,Van Rietschoten J,Courageot J,Miquelis R

更新日期：1990-06-29 00:00:00

abstract：:We found that pyridoxal phosphate shows considerable inhibition of cathepsins. CLIK-071, in which the phosphate ester of position 3 of pyridoxal phosphate was replaced by propionate, strongly inhibited cathepsin B. Three new types of synthetic pyridoxal propionate derivatives showing specific inhibition of cathepsin K...

journal_title：Biochemical and biophysical research communications

authors： Katunuma N,Matsui A,Inubushi T,Murata E,Kakegawa H,Ohba Y,Turk D,Turk V,Tada Y,Asao T

更新日期：2000-01-27 00:00:00

abstract：:FGF1 and FGF2 support hematopoietic stem and progenitor cells (HSPCs) under stress conditions. In this study, we show that fibroblast growth factor (FGF7) may be a novel niche factor for HSPC support and leukemic growth. FGF7 expression was attenuated in mouse embryonic fibroblasts (MEFs) deficient for the MED1 subuni...

journal_title：Biochemical and biophysical research communications

authors： Ishino R,Minami K,Tanaka S,Nagai M,Matsui K,Hasegawa N,Roeder RG,Asano S,Ito M

更新日期：2013-10-11 00:00:00

abstract：:We investigated the effect of chronic alcohol ingestion on buccal mucosal ulcer healing by analyzing the interplay between mucosal expression of tumor necrosis factor-alpha (TNF-alpha), endothelin-1 (ET-1), and interleukin-4 (IL-4). Chronic ulceration was induced in rats maintained for 5 weeks on alcohol-containing or...

journal_title：Biochemical and biophysical research communications

authors： Slomiany BL,Piotrowski J,Slomiany A

更新日期：1999-04-13 00:00:00

abstract：:The aorta-gonad-mesonephros (AGM) region is involved in the generation and maintenance of the first definitive hematopoietic stem cells (HSCs). A mouse AGM-derived cell line, AGM-S3, was shown to support the development of HSCs. To elucidate the molecular mechanisms regulating early hematopoiesis, we obtained subclone...

journal_title：Biochemical and biophysical research communications

authors： Nagao K,Ohta T,Hinohara A,Tahara T,Hagiwara T,Maeda Y,Yoneya T,Sohma Y,Heike T,Nakahata T,Inagaki Y,Nishikawa M

更新日期：2008-12-05 00:00:00

abstract：:The in vitro heat effect on protein characteristics of thermostable enzyme was examined using a cyclodextrin glucanotransferase (CGTase, EC 2.4.1.19) from the hyperthermophilic archaeon Thermococcus sp. B1001 as a model protein. The recombinant form of CGTase was obtained as an inclusion body from Escherichia coli cel...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto T,Shiraki K,Fujiwara S,Takagi M,Fukui K,Imanaka T

更新日期：1999-11-01 00:00:00

abstract：:The mitochondrial respiratory chain (MRC) supplies the majority of the energy requirements of most eucaryotic cells. A null mutation in the Caenorhabditis elegans nuo-1 gene encoding a subunit of complex I (NADH-ubiquinone oxidoreductase) is lethal, leading to a developmental arrest at the third larval stage. To ident...

journal_title：Biochemical and biophysical research communications

authors： Ndegwa S,Lemire BD

更新日期：2004-07-09 00:00:00

abstract：:Amyloid-beta (Abeta) is the core component of senile plaques, which are the pathological markers for Alzheimer's disease and cerebral amyloid angiopathy. DNA methylation/demethylation plays a crucial role in gene regulation and could also be responsible for presentation of senescence. Oxidative stress, which may be in...

journal_title：Biochemical and biophysical research communications

authors： Chen KL,Wang SS,Yang YY,Yuan RY,Chen RM,Hu CJ

更新日期：2009-01-02 00:00:00

abstract：:An apparently novel human plasma and urinary protein of low molecular weight was isolated from several highly purified preparations of protein HC by gel chromatography and high voltage electrophoresis with a yield of about 8 mg/g. The protein has a molecular weight of about 20,000, neutral electrophoretic mobility at ...

journal_title：Biochemical and biophysical research communications

authors： López-Otin C,Grubb AO,Méndez E

更新日期：1983-11-30 00:00:00

abstract：:Adipose tissue is an active endocrine organ producing a variety of cytokines and chemokines, which may be involved in the deregulation of glucose and lipid homeostasis as well as in the inflammatory state observed in obesity. We have shown previously that differentiated human adipocytes secrete a variety of cytokines ...

journal_title：Biochemical and biophysical research communications

authors： Sell H,Dietze-Schroeder D,Eckardt K,Eckel J

更新日期：2006-05-12 00:00:00

abstract：:Voltage-gated ion channels (VGCs) mediate selective diffusion of ions across cell membranes to enable many vital cellular processes. Three-dimensional structure data are lacking for VGC proteins; hence, to better understand their function, there is a need to identify the conserved motifs using sequence analysis method...

journal_title：Biochemical and biophysical research communications

authors： Guda P,Bourne PE,Guda C

更新日期：2007-01-12 00:00:00

abstract：:A method to prepare amyloid-like fibrils functionalized with magnetic nanoparticles has been developed. The amyloid-like fibrils are prepared in a two step procedure, where insulin and magnetic nanoparticles are mixed simply by grinding in the solid state, resulting in a water soluble hybrid material. When the hybrid ...

journal_title：Biochemical and biophysical research communications

authors： Andersson BV,Skoglund C,Uvdal K,Solin N

更新日期：2012-03-23 00:00:00

abstract：:The N-terminal leucine residue of snake venom cardiotoxin II (CTX II) (Naja naja atra) was systematically replaced with D-leucine (CTXII-L1-D-L), glycine (CTXII-L1G) or deleted [CTXII-(2-60)] to study the role of leucine residue in CTX II molecule. CTX II, CTXL1-D-L, CTXL1G and CTX(2-60) were produced by chemical synt...

journal_title：Biochemical and biophysical research communications

authors： Wu CY,Chen WC,Ho CL,Chen ST,Wang KT

更新日期：1997-04-28 00:00:00

abstract：:Plants possess several defense mechanisms against pathogenic attack. One of these defenses is the use of protease inhibitor proteins, which interfere in the development and growth of pathogens. Sugarcane productivity can be impacted by the plant's susceptibility to fungal diseases that result in production losses. A r...

journal_title：Biochemical and biophysical research communications

authors： Soares-Costa A,Beltramini LM,Thiemann OH,Henrique-Silva F

更新日期：2002-09-06 00:00:00

abstract：:Eleven genes, including pax2a, were selected as candidate ovulation-inducing genes on the basis of microarray analysis and RNA sequencing in our previous study. The purpose of this study was to investigate the role of the pax2a gene in the ovulation-inducing process. F2 pax2a homozygous mutant zebrafish possessing a d...

journal_title：Biochemical and biophysical research communications

authors： Pachoensuk T,Fukuyo T,Wanlada K,Rezanujjaman M,Rahaman MM,Sasaoka K,Sarwar Jyoti MM,Rana MR,Ali MH,Tokumoto T

更新日期：2020-12-10 00:00:00

abstract：:Large tumor suppressor kinase 1 (LATS1) is a serine/threonine kinase of the AGC kinase family in mammals and involved in various biological processes, it is a key regulator of cell cycle progression. However, the role of LATS1 in central nervous system trauma is still unknown. In present study, we performed an acute s...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Chen M

更新日期：2018-10-20 00:00:00

abstract：:Pretreatment of brain synaptic membrane homogenates with Triton X-100 resulted in a drastic disclosure of [3H] glutamate (Glu) binding activity which was sensitive to one of the central Glu receptor agonists, N-methyl-D-aspartic acid (NMDA). The NMDA-sensitive binding was inversely dependent on the incubation temperat...

journal_title：Biochemical and biophysical research communications

authors： Ogita K,Yoneda Y

更新日期：1988-06-16 00:00:00

abstract：:Septic shock induced by lipopolysaccharide (LPS) is characterized by serious systemic inflammatory response and robust production of pro-inflammatory cytokines from activated macrophages. Damage-associated molecular patterns (DAMPs) secreted by activated macrophages are key contributors to septic shock. However, the c...

journal_title：Biochemical and biophysical research communications

authors： He Y,Peng Y,Tao L,Peng Z,Yang H

更新日期：2020-07-05 00:00:00

abstract：:CAD/DFF40, the nuclease responsible for DNA fragmentation during apoptosis, exists as a heterodimeric complex with DFF45/ICAD. This study determines the molecular mechanisms of regulation of DFF40 via the chaperone and inhibition activities of DFF45. We analyze proteins corresponding to the fragments (D1, D2, and D3) ...

journal_title：Biochemical and biophysical research communications

authors： McCarty JS,Toh SY,Li P

更新日期：1999-10-14 00:00:00

abstract：:Sorting motifs are involved in the transport of diverse proteins. In the present study, we identified a hydrophobic peptide (WRPWRNFWWSIRVPWRRN) that was able to target enhanced green fluorescent protein- or DsRed2-enriched vesicular-like sub-compartments of the endoplasmic reticulum (ER). Analysis of mutation constru...

journal_title：Biochemical and biophysical research communications

authors： Nie YW,Wang M,Zhang P,Huan L,Liu DJ

更新日期：2016-04-22 00:00:00

abstract：:We have identified by protein sequencing the precursor of beta protein in newborn rat brain. A rabbit antibody was raised against a synthetic peptide corresponding to the carboxyl-terminal 30 residues (666-695) of the putative beta-amyloid protein precursor (Kang et al. 1987). The antiserum recognized multiple bands a...

journal_title：Biochemical and biophysical research communications

authors： Takio K,Hasegawa M,Titani K,Ihara Y

更新日期：1989-05-15 00:00:00