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Pax2a is expressed in oocytes and is responsible for early development and oogenesis in zebrafish.

Abstract：

:Eleven genes, including pax2a, were selected as candidate ovulation-inducing genes on the basis of microarray analysis and RNA sequencing in our previous study. The purpose of this study was to investigate the role of the pax2a gene in the ovulation-inducing process. F2 pax2a homozygous mutant zebrafish possessing a deletion of 6 nucleotides were established in this study. However, the deletion included the start codon (ATG) of the pax2a gene, and the Pax2a protein was still detected, which indicated that the deletion caused a shift in the start codon to the next ATG, resulting in a 12-amino acid deletion. F2 pax2a homozygous mutant zebrafish showed ovulation. However, the embryos showed an abnormal oval shape at the epiboly stage that resulted in yolk and tail formation abnormalities and heart edema. The surviving F3 homozygous mutants did not develop ovaries. Pax2a was detected in oocytes and eggs but not after the Prim-22 stage. It is suggested that pax2a is expressed as a maternal gene in oocytes and is necessary for oogenesis and early development.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Pachoensuk T,Fukuyo T,Wanlada K,Rezanujjaman M,Rahaman MM,Sasaoka K,Sarwar Jyoti MM,Rana MR,Ali MH,Tokumoto T

doi

10.1016/j.bbrc.2020.09.059

subject

Has Abstract

pub_date

2020-12-10 00:00:00

pages

592-599

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)31800-3

journal_volume

533

pub_type

杂志文章

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