Receptor for 1,25-dihydroxyvitamin D in a vascular smooth muscle cell line derived from rat aorta.

Abstract:

:The presence of a specific receptor for 1,25-dihydroxyvitamin D (1,25(OH)2D) was investigated in a cell line A7r5 derived from fetal aorta. 1,25(OH)2[3H]D3 binding to cytosol was saturated at 0.6-1 nM, and Scatchard analysis yielded dissociation constant and binding sites, (3.02 +/- 0.4) X 10(-11) M and 33.9 +/- 5.8 fmol/mg protein, respectively. Sucrose density gradient analysis revealed the sedimentation constant 3.2 S. Furthermore, the receptor protein had affinity for DNA-cellulose column and eluted with 0.2 M KCl. These data suggest that vascular smooth muscle cell may be a target tissue of vitamin D.

authors

Kawashima H

doi

10.1016/0006-291x(87)90681-4

subject

Has Abstract

pub_date

1987-07-15 00:00:00

pages

1-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90681-4

journal_volume

146

pub_type

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