Abstract：
:Aging is associated with extensive cognitive impairments, although the biochemical and physiological basis of these deficits are unknown. As the hippocampus plays a vital role in cognitive functions, we have selected this tissue to analyze changes in gene expression at two different ages. Array technology is utilized to explore how gene expression in hippocampus is affected by accelerated cognitive impairment in Senescence-Accelerated Mouse (SAM P8) strain. We show that the expression of genes associated with stress response and xenobiotic metabolism are strongly affected at a time when cognitive impairment occurs. Affected genes include those involved both in signaling and chaperone function. The effector and regulator family of chaperones, which play an important role in protein folding, and also the xenobiotic metabolizing enzymes that play crucial role in antioxidant systems, show significant changes in gene expression between 4 and 12 months.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Kumar VB,Franko MW,Farr SA,Armbrecht HJ,Morley JEdoi
10.1006/bbrc.2000.2719subject
Has Abstractpub_date
2000-06-16 00:00:00pages
657-61issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(00)92719-0journal_volume
272pub_type
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journal_title：Biochemical and biophysical research communications
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