当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Loss of O-GlcNAc transferase in neural stem cells impairs corticogenesis.

Loss of O-GlcNAc transferase in neural stem cells impairs corticogenesis.

Abstract：

:The proper development of the cerebral cortex is essential for brain formation and functioning. O-GlcNAcylation, an important posttranslational modification, regulates the pathways critical for neuronal health and the survival of the cerebral cortex in neurodegenerative diseases. However, the role of O-GlcNAcylation in regulating cerebral cortical development at the embryonic and early postnatal (0-21 days) stages is still largely unknown. Here we report that the selective deletion of O-GlcNAc transferase (OGT) in neural stem cells (NSCs) in mice led to a series of severe brain developmental deficits, including dramatic shrinkage of cortical and hippocampal histoarchitecture, widespread neuronal apoptosis, decrease in cell proliferation, induction of endoplasmic reticulum (ER) stress, and inhibition of neuronal dendritic and axonal differentiation. The pathology of corticogenesis deficits caused by OGT deletion may largely rely on complicated biological processes, such as proliferation, apoptosis and differentiation. Our results suggest that dysfunctional O-GlcNAcylation in NSCs may be an important contributor to neurodevelopmental diseases.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cheng J,Wu Y,Chen L,Li Y,Liu F,Shao J,Huang M,Fan M,Wu H

doi

10.1016/j.bbrc.2020.08.084

subject

Has Abstract

pub_date

2020-11-19 00:00:00

pages

541-547

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)31681-8

journal_volume

532

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Protective effect of recombinant soluble neprilysin against β-amyloid induced neurotoxicity.

    abstract：:A few decades ago, researchers found emerging evidence showing that a number of sequential events lead to the pathological cascade of Alzheimer's disease (AD) which is caused by the accumulation of amyloid beta (Aβ), a physiological peptide, in the brain. Therefore, regulation of Aβ represents a crucial treatment appr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.06.103

    authors： Oh JH,Choi S,Shin J,Park JS

    更新日期：2016-09-02 00:00:00

  • In silico assessment of interaction of sea anemone toxin APETx2 and acid sensing ion channel 3.

    abstract：:Acid sensing ion channels (ASICs) are proton-gated cation channels that are expressed throughout the nervous system and have been implicated in mediating sensory perception of noxious stimuli. Amongst the six ASIC isoforms, ASIC1a, 1b, 2a and 3 form proton-gated homomers, which differ in their activation and inactivat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.05.130

    authors： Rahman T,Smith ES

    更新日期：2014-07-18 00:00:00

  • Glutathione S-transferase in yeast: induction of mRNA, cDNA cloning and expression in Escherichia coli.

    abstract：:Glutathione S-transferase Y-2 mRNA synthesis was induced in yeast Issatchenkia orientalis approximately 37-fold by cultivation with o-dinitrobenzene. A cDNA library complementary to poly (A)+RNA of I. orientalis grown with o-dinitrobenzene was screened by colony hybridization. Twenty positive clones were obtained from...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90726-4

    authors： Tamaki H,Kumagai H,Tochikura T

    更新日期：1990-10-30 00:00:00

  • Tissue distribution and characterization of prorenin-converting enzyme in mouse.

    abstract：:Renin is produced from an inactive precursor, prorenin, through endoproteolytic cleavage at paired basic amino-acid residues. Using (35S)methionine-labeled prorenin, that was synthesized with Xenopus oocyte expression system, as a substrate, we have determined the tissue distribution and the nature of prorenin-convert...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(89)80057-9

    authors： Nakayama K,Kim WS,Hatsuzawa K,Hashiba K,Murakami K

    更新日期：1989-01-31 00:00:00

  • Up-regulated expression of beta3 integrin induced by dengue virus serotype 2 infection associated with virus entry into human dermal microvascular endothelial cells.

    abstract：:Permeability alteration of microvascular endothelia is a factor in the plasma leakage produced by dengue virus (DV) infection, and beta3 integrin plays central roles in maintaining capillary integrity and regulating vascular permeability. In this study, interaction between beta3 integrin and DV serotype 2 (DV2) was in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.03.051

    authors： Zhang JL,Wang JL,Gao N,Chen ZT,Tian YP,An J

    更新日期：2007-05-11 00:00:00

  • Characterisation of two novel CYP4 genes from the marine polychaete Nereis virens and their involvement in pyrene hydroxylase activity.

    abstract：:Cytochrome P450 enzymes (CYP enzymes) catalyse the initial step in biotransformation of xenobiotics like polycyclic aromatic hydrocarbons (PAHs). The marine polychaete Nereis virens has a high capacity for biotransformation of PAHs. In the present study, the complete cDNA sequences of two novel CYP genes isolated from...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.08.189

    authors： Jørgensen A,Rasmussen LJ,Andersen O

    更新日期：2005-10-28 00:00:00

  • Serine/threonine/tyrosine-interacting-like protein 1 (STYXL1), a pseudo phosphatase, promotes oncogenesis in glioma.

    abstract：:Phosphatases play an important role in cellular signaling and are often found dysregulated in cancers including glioblastoma (GBM). A comprehensive bioinformatics analysis of phosphatases (n = 403) in multiple datasets revealed their deregulation in GBM. Among the differentially regulated phosphatases (n = 186; 46.1%)...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2019.05.093

    authors： Tomar VS,Baral TK,Nagavelu K,Somasundaram K

    更新日期：2019-07-12 00:00:00

  • The motilin antagonist ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit.

    abstract：:Studies on the physiological role of motilin, and more recently, on the relationship between motilin and erythromycin A, have been hampered by the lack of antagonists. We now have discovered such a compound. ANQ-11125 displaces motilin bound to an homogenate of rabbit antral smooth muscle tissue. The dissociation cons...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1060

    authors： Peeters TL,Depoortere I,Macielag MJ,Dharanipragada R,Marvin MS,Florance JR,Galdes A

    更新日期：1994-01-28 00:00:00

  • Cyclic AMP decreases LDL catabolism and cholesterol synthesis in the human hepatoma cell line HepG2.

    abstract：:A 24h pretreatment of the human hepatoma cell line HepG2 with dibutyryl cyclic AMP in the presence of theophylline induced a dose dependent decrease in low density lipoprotein binding, uptake and degradation. This effect is most likely due to a reduction of the LDL receptor number. Sterol synthesis from sodium acetate...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80858-1

    authors： Maziere C,Maziere JC,Salmon S,Auclair M,Mora L,Moreau M,Polonovski J

    更新日期：1988-10-14 00:00:00

  • C-terminal phosphorylation of SPAK and OSR1 kinases promotes their binding and activation by the scaffolding protein MO25.

    abstract：:SPAK and OSR1 are two protein kinases that play important roles in regulating the function of numerous ion co-transporters. They are activated by two distinct mechanisms that involve initial phosphorylation at their T-loops by WNK kinases and subsequent binding to a scaffolding protein termed MO25. To understand this ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.07.128

    authors： Mehellou Y,Alamri MA,Dhiani BA,Kadri H

    更新日期：2018-09-10 00:00:00

  • Biochemical thresholds for pathological presentation of ATP synthase deficiencies.

    abstract：:Mitochondrial ATP synthase is responsible for production of the majority of cellular ATP. Disorders of ATP synthase in humans can be caused by numerous mutations in both structural subunits and specific assembly factors. They are associated with variable pathogenicity and clinical phenotypes ranging from mild to the m...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.033

    authors： Nuskova H,Mikesova J,Efimova I,Pecinova A,Pecina P,Drahota Z,Houstek J,Mracek T

    更新日期：2020-01-22 00:00:00

  • The two phases of regulated exocytosis in permeabilized pancreatic acini are modulated differently by heterotrimeric G-proteins.

    abstract：:In this study we examined the influence on AlF4- and GTP gamma S on amylase secretion from alpha toxin permeabilized pancreatic acini. AlF4- only activates heterotrimeric G-proteins, whereas GTP gamma S activates both small ras-like GTP-binding proteins and heterotrimeric G-proteins (Kahn, R. A., J. Biol. Chem., 266, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8350

    authors： Padfield PJ,Panesar N

    更新日期：1998-04-17 00:00:00

  • A histone 1-like antigen is a component of the nuclear envelope.

    abstract：:Rabbit antibodies have been raised against rat liver nuclear envelopes. An enzyme-linked immunosorbent assay (ELISA) demonstrated high titer antiserum specific for the nuclear envelope preparation. Immunocytochemical studies showed that the antiserum stained the nuclear envelopes, but not intra-nuclear components of H...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80895-7

    authors： Venkatraman JT,Gohill J,Fritzler MJ,Lefebvre YA

    更新日期：1988-10-31 00:00:00

  • Stimulation of the class-A scavenger receptor induces neutrophil extracellular traps (NETs) by ERK dependent NOX2 and ROMO1 activation.

    abstract：:Neutrophil extracellular traps (NETs) play a critical role in host antimicrobial response whereas they are also implicated in the pathogenesis of inflammatory and autoimmunediseases. Generation of reactiveoxygen species (ROS) is key to NETs formation. A variety of stimulatory ligands have been found to enhance ROS pro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.02.142

    authors： Zhu Y,Yang Y,Li F,Fan S,Chen X,Lu Y,Wei Y,Chen Q,Xia L,Tang J,Huang Q,Zhu Q,Zheng J,Liu X

    更新日期：2019-04-16 00:00:00

  • The N-terminal domain of tumor suppressor p53 is involved in the molecular interaction with the anti-apoptotic protein Bcl-Xl.

    abstract：:Emerging evidences suggest that transcription-independent mechanism of p53 appears to make an important contribution to the overall p53-dependent apoptosis. Recently, it has been postulated that the DNA-binding domain of p53 can interact with Bcl-Xl, and subsequently the proposed molecular interaction has been shown b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.12.227

    authors： Xu H,Tai J,Ye H,Kang CB,Yoon HS

    更新日期：2006-03-24 00:00:00

  • Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation.

    abstract：:Leucine-rich repeat kinase 2 (LRRK2) is the molecule responsible for autosomal-dominant Parkinson's disease (PD), PARK8, but the etiologic effects of its mutation remain unknown. In the present study, we investigated a novel mechanism for the neurodegeneration induced by I2020T mutant LRRK2. Using native gel electroph...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.11.113

    authors： Ohta E,Kawakami F,Kubo M,Obata F

    更新日期：2013-01-11 00:00:00

  • Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptor.

    abstract：:A cDNA encoding non-selective type (ETB) of endothelin receptor was isolated from a human liver cDNA library. The cDNA had an open reading frame encoding a protein of 442 amino acid residues with a relative Mr of 49,643. The deduced amino acid sequence of human ETB receptor was 88% and 64% identical to those of rat lu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91944-8

    authors： Nakamuta M,Takayanagi R,Sakai Y,Sakamoto S,Hagiwara H,Mizuno T,Saito Y,Hirose S,Yamamoto M,Nawata H

    更新日期：1991-05-31 00:00:00

  • cDNA cloning and expression of timothy grass (Phleum pratense) pollen profilin in Escherichia coli: comparison with birch pollen profilin.

    abstract：:Profilin, an actin-binding protein, was previously described as a ubiquitous allergen which is responsible for cross-reactivities in about 20% of pollen and food allergic patients. A complete cDNA clone coding for timothy grass (Phelum pratense) pollen profilin was isolated using allergic patients IgE. The deduced ami...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1201

    authors： Valenta R,Ball T,Vrtala S,Duchêne M,Kraft D,Scheiner O

    更新日期：1994-02-28 00:00:00

  • Loss of MURC/Cavin-4 induces JNK and MMP-9 activity enhancement in vascular smooth muscle cells and exacerbates abdominal aortic aneurysm.

    abstract：:Abdominal aortic aneurysm (AAA) is relatively common in elderly patients with atherosclerosis. MURC (muscle-restricted coiled-coil protein)/Cavin-4 modulating the caveolae function of muscle cells is expressed in cardiomyocytes, skeletal muscle cells and smooth muscle cells. Here, we show a novel functional role of MU...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.04.096

    authors： Miyagawa K,Ogata T,Ueyama T,Kasahara T,Nakanishi N,Naito D,Taniguchi T,Hamaoka T,Maruyama N,Nishi M,Kimura T,Yamada H,Aoki H,Matoba S

    更新日期：2017-06-03 00:00:00

  • Molecular characterization of human and bovine ceruloplasmin using MALDI-TOF mass spectrometry.

    abstract：:Using SDS-PAGE and MALDI-TOF mass spectrometry, we investigated the difference in the molecular structure between human and bovine ceruloplasmin. In both cases, we found that the protein is present in two majors forms of different molecular mass. The difference between human and bovine ceruloplasmin was more obvious w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5881

    authors： Boivin S,Aouffen M,Fournier A,Mateescu MA

    更新日期：2001-11-09 00:00:00

  • Effects of replacement of tryptophan-140 by phenylalanine or glycine on the function of Escherichia coli aspartate aminotransferase.

    abstract：:Trp140 of E. coli aspartate aminotransferase has been converted to Phe or Gly by site-directed mutagenesis. As compared to the wild-type enzyme, either of the mutant enzymes showed 10- to 100-fold increase in Km's for natural dicarboxylic substrates, but did not show appreciable changes in Km's for aromatic substrates...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)92037-z

    authors： Hayashi H,Inoue Y,Kuramitsu S,Morino Y,Kagamiyama H

    更新日期：1990-03-16 00:00:00

  • Ambra1 modulates starvation-induced autophagy through AMPK signaling pathway in cardiomyocytes.

    abstract：:Recent research has revealed a role for Ambra1, an autophagy-related gene-related (ATG) protein, in the autophagic pro-survival response, and Ambra1 has been shown to regulate Beclin1 and Beclin1-dependent autophagy in embryonic stem cells and cancer cells. However, whether Ambra1 plays an important role in the autoph...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.08.017

    authors： Shi C,Wu J,Fu M,Zhang B,Wang J,Yang X,Chi Y

    更新日期：2014-09-26 00:00:00

  • A novel role for PTK2B in cultured beige adipocyte differentiation.

    abstract：:Adipocyte differentiation is a tightly regulated process which requires the sequential and organized expression of numerous genes and proteins. Phosphorylation of cytoplasmic proteins and key transcription factors represents a critical regulatory mechanism of the process leading to adipocyte maturation and modulation ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.05.021

    authors： Ni B,Farrar JS,Chen S,Lownik JC,Celi FS

    更新日期：2018-07-02 00:00:00

  • Uncoupling of mitochondrial oxidative phosphorylation by hexetidine.

    abstract：:To gain further insight into the biochemical properties of the antibacterial hexetidine, isolated rat liver mitochondria were added with this drug and investigation made of certain features related to mitochondrial bioenergetics. Hexetidine was found to cause oxidation of intramitochondrial pyridine nucleotides and st...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91001-1

    authors： D'Arcangelo G,Barile M,Passarella S,Quagliariello E

    更新日期：1987-09-15 00:00:00

  • Characterization of a rat variant alpha-fetoprotein.

    abstract：:The rat adult liver and hepatocyte lines express an 1.7-kb variant alpha-fetoprotein (AFP) mRNA which differs from the 2.2-kb fetal AFP transcript in sequence in the 5' region. Here we report the characterization of a variant AFP cDNA, ARFP9, which is 1349 bp in length and encodes a 325 amino acid polypeptide. Nucleot...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91674-f

    authors： Watanabe T,Jimenez-Molina JL,Chou JY

    更新日期：1992-06-15 00:00:00

  • Nickel(II) acetate-treated Chinese hamster ovary cells differentially express Vimentin, hSNF2H homologue, and H ferritin.

    abstract：:In probing the possible non-genotoxic molecular mechanism(s) of nickel(II)-induced carcinogenesis, we performed a non-radioactive mRNA differential display analysis for nickel(II) acetate-treated Chinese hamster ovary cells (CHO-K1-BH4). Three out of thirty differentially expressed cDNAs had sequences highly similar t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0692

    authors： Lee SH,Shiao YH,Plisov SY,Kasprzak KS

    更新日期：1999-05-19 00:00:00

  • RETRACTED: Anti-angiogenic effect of Interleukin-26 in oxygen-induced retinopathy mice via inhibiting NFATc1-VEGF pathway.

    abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of authors. The Journal received an expression of concern from a reader, which noted that: “The problem is that there is no IL-26 gene in t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,收录出版

    doi：10.1016/j.bbrc.2018.04.004

    authors： Bao J,Lv Z,Wang S

    更新日期：2018-05-23 00:00:00

  • Gambogic acid activates AMP-activated protein kinase in mammalian cells.

    abstract：:AMP-activated protein kinase (AMPK) plays a key role in maintaining intracellular and whole-body energy homeostasis. Activation of AMPK has been shown to ameliorate the symptoms of metabolic diseases, such as type 2 diabetes and obesity. Here we show that gambogic acid (GB), a known antitumor agent, activates AMPK by ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.06.078

    authors： Zhao B,Shen H,Zhang L,Shen Y

    更新日期：2012-07-20 00:00:00

  • RAP80 binds p32 to preserve the functional integrity of mitochondria.

    abstract：:RAP80, a member of the BRCA1-A complex, is a well-known crucial regulator of cell cycle checkpoint and DNA damage repair in the nucleus. However, it is still unclear whether Rap80 localizes to another region outside the nucleus and plays different roles with its partners. Here, we found mitochondrial p32 as a novel bi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.08.077

    authors： Chung HJ,Korm S,Lee SI,Phorl S,Noh S,Han M,Naskar R,Kim H,Lee JY

    更新日期：2017-10-21 00:00:00

  • Fad104, a positive regulator of adipogenesis, negatively regulates osteoblast differentiation.

    abstract：:Fad104 (factor for adipocyte differentiation 104) is a novel gene expressed temporarily in the early stages of adipocyte differentiation. Previously, we showed that fad104 promotes adipocyte differentiation in mouse 3T3-L1 cells and mouse embryonic fibroblasts (MEFs). Furthermore, we reported that implanted wild-type ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.05.077

    authors： Kishimoto K,Kato A,Osada S,Nishizuka M,Imagawa M

    更新日期：2010-06-25 00:00:00