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NF-kappaB blockade reduces the O2-evoked rise in Na+ conductance in fetal alveolar cells.

Abstract：

:Electrophoretic mobility shift assays revealed minimal levels of NF-kappaB activity in rat distal lung epithelial cells cultured at fetal (23 mmHg) or adult alveolar (100 mmHg) P(O2), but revealed significant activation of this transcription factor in cells exposed to a rise in P(O2) mimicking that experienced at birth. This response was entirely abolished by pretreating cells with 5 mM sulfasalazine (SSA). This shift in P(O2) also evoked a rise in apical Na+ conductance (G(Na+)) that may underlie the O2-evoked stimulation of Na+ transport seen in these cells. Pretreatment with SSA had no effect upon G(Na+) in cells cultured continually at adult or fetal P(O2) but did inhibit the increase in G(Na+) seen in cells that had experienced the rise in P(O2). O2-evoked activation of NF-kappaB may thus mediate the increased Na+ transport that occurs when the distal lung epithelial cells are exposed to a physiologically-relevant increase in P(O2).

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Haddad JJ,Collett A,Land SC,Olver RE,Wilson SM

doi

10.1006/bbrc.2001.4453

subject

Has Abstract

pub_date

2001-03-09 00:00:00

pages

987-92

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(01)94453-5

journal_volume

281

pub_type

杂志文章

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