Analysis of a 762-bp proximal leptin promoter to drive and control regulation of transgene expression of growth hormone receptor in mice.

abstract：:C-type natriuretic peptide (CNP) which potently stimulates particulate guanylate cyclase activity in cultured rat vascular smooth muscle cells (VSMC) inhibited serum-induced DNA synthesis of the cells 10-fold more effectively than alpha-human atrial natriuretic peptide (alpha-hANP). The inhibitory effect of CNP was mi...

journal_title：Biochemical and biophysical research communications

authors： Furuya M,Yoshida M,Hayashi Y,Ohnuma N,Minamino N,Kangawa K,Matsuo H

更新日期：1991-06-28 00:00:00

abstract：:Histamine induced a concentration-dependent increase in intracellular cyclic-AMP of the two human melanoma cell lines SK23 and DX3.LT5.1; maximal stimulation was obtained with 17.8 microM histamine which consistently produced greater than 50-fold increases in the cyclic AMP content of both cell lines. The dose-respons...

journal_title：Biochemical and biophysical research communications

authors： Whitehead RJ,Taylor DJ,Evanson JM,Hart IR,Woolley DE

更新日期：1988-02-29 00:00:00

abstract：:ATG4B belongs to the autophagin family of cysteine proteases required for autophagy, an emerging target of cancer therapy. Developing pharmacological ATG4B inhibitors is a very active area of research. However, detailed studies on the role of ATG4B during anticancer therapy are lacking. By analyzing PC-3 and C4-2 pros...

journal_title：Biochemical and biophysical research communications

authors： Tran E,Chow A,Goda T,Wong A,Blakely K,Rocha M,Taeb S,Hoang VC,Liu SK,Emmenegger U

更新日期：2013-11-29 00:00:00

abstract：:Reactive oxygen species (ROS) are an important factor in the development of skin lesions in diabetes. A new antioxidant, hydrogen, can selectively neutralize hydroxyl radicals (()OH) and peroxynitrite (ONOO(-)) in cell-free systems, whereas it seldom reacts with other ROS. Fibroblasts are a key component of skin. In t...

journal_title：Biochemical and biophysical research communications

authors： Yu P,Wang Z,Sun X,Chen X,Zeng S,Chen L,Li S

更新日期：2011-06-03 00:00:00

abstract：:A human thyroid cDNA library was screened by hybridization with a dog thyrotropin receptor (TSHr) cDNA. Sequencing of the resulting clones identified a 2292 residue open reading frame encoding a 744 amino acid mature polypeptide presenting 90.3% similarity with the dog TSHr. Two major transcripts (4.6 and 4.4 kilobase...

journal_title：Biochemical and biophysical research communications

authors： Libert F,Lefort A,Gerard C,Parmentier M,Perret J,Ludgate M,Dumont JE,Vassart G

更新日期：1989-12-29 00:00:00

abstract：:We have investigated the effect of PARP gene inactivation on the expression of wild-type (wt) p53 protein. Using immortalized fibroblasts from control and PARP knock-out mice we have found by immunoblotting with the PAb421 antibody a profound decrease of the p53 expression to a barely detectable level in PARP knock-ou...

journal_title：Biochemical and biophysical research communications

authors： Schmid G,Wang ZQ,Wesierska-Gadek J

更新日期：1999-02-16 00:00:00

abstract：:This communication reports the isolation, purification and characterization of key enzymes involved in dissimilatory sulfate reduction of a sulfate reducing bacterium classified as Desulfovibrio desulfuricans subspecies desulfuricans New Jersey (NCIMB 8313) (Ddd NJ). The chosen strain, originally recovered from a corr...

journal_title：Biochemical and biophysical research communications

authors： Pereira AS,Franco R,Feio MJ,Pinto C,Lampreia J,Reis MA,Calvete J,Moura I,Beech I,Lino AR,Moura JJ

更新日期：1996-04-16 00:00:00

abstract：:Ghrelin, a gastric-derived peptide, has recently been identified as an endogenous natural ligand for the growth hormone (GH) secretagogue receptor. However, secretory characteristics of ghrelin are still obscure in ruminants. To investigate the diurnal rhythm in ghrelin secretion and its relationship to GH secretion, ...

journal_title：Biochemical and biophysical research communications

authors： Sugino T,Hasegawa Y,Kikkawa Y,Yamaura J,Yamagishi M,Kurose Y,Kojima M,Kangawa K,Terashima Y

更新日期：2002-07-12 00:00:00

abstract：:Several rich sources of polyphenols stimulate the endothelial formation of nitric oxide (NO), a potent vasoprotecting factor, via the redox-sensitive activation of the PI3-kinase/Akt pathway leading to the phosphorylation of endothelial NO synthase (eNOS). The present study examined the molecular mechanism underlying ...

journal_title：Biochemical and biophysical research communications

authors： Auger C,Kim JH,Chabert P,Chaabi M,Anselm E,Lanciaux X,Lobstein A,Schini-Kerth VB

更新日期：2010-02-26 00:00:00

abstract：:Lipases are widely present in various plants, animals and microorganisms, constituting a large category of enzymes. They have the ability to catalyze the cleavage of ester bonds. The lipase CinB from Enterobacter asburiae (E. asburiae) is an acetyl esterase. The primary amino acid sequence suggests that the EaCinB pro...

journal_title：Biochemical and biophysical research communications

authors： Shang F,Lan J,Liu W,Chen Y,Wang L,Zhao J,Chen J,Gao P,Ha NC,Quan C,Nam KH,Xu Y

更新日期：2019-11-05 00:00:00

abstract：:We have demonstrated binding sites for LTB4 in guinea pig lung membranes. Binding of [3H]-LTB4 was of high affinity (Kd = 0.76 nM), saturable and linear with protein concentration (0.2-1.2 mg/ml). Scatchard and Hill's plot analysis indicated a single class of binding site with a Hill's coefficient of 0.99 +/- 0.08 (n ...

journal_title：Biochemical and biophysical research communications

authors： Saad M,Wong K

更新日期：1987-02-27 00:00:00

abstract：:Chlorpromazine is a potent inhibitor of calmodulin and can alter the accumulation, metabolism, and incorporation into RNA of several fluoropyrimidine drugs. Using S-180 murine sarcoma cells, the accumulation of the base Fluorouracil and its metabolism to ribonucleotides is enhanced by chlorpromazine treatment, as meas...

journal_title：Biochemical and biophysical research communications

authors： Tseng A Jr,Brooks M,Cadman E

更新日期：1986-07-31 00:00:00

abstract：:The carnitine/acylcarnitine carrier from rat liver mitochondria was overexpressed in Escherichia coli. The expressed protein, recovered as inclusion bodies, was solubilized with sarkosyl and purified by Sephadex G-200 and celite chromatography. A yield of 15 mg of purified transport protein per liter of cell culture w...

journal_title：Biochemical and biophysical research communications

authors： Indiveri C,Iacobazzi V,Giangregorio N,Palmieri F

更新日期：1998-08-28 00:00:00

abstract：:Polycomb Group (PcG) genes encode proteins that form large multimeric and chromatin-associated complexes implicated in the stable repression of developmentally essential genes. HPH2, the Homo sapiens polyhomeotic homologue 2, functions as one of the subunits of PcG complex 1. In our study, SIAH-1, an E3 ligase, could ...

journal_title：Biochemical and biophysical research communications

authors： Wu H,Lin Y,Shi Y,Qian W,Tian Z,Yu Y,Huo K

更新日期：2010-07-02 00:00:00

abstract：:Epidemiologic studies suggest that low to moderate consumption of red wine is inversely associated with the risk of coronary heart disease; the protection is in part attributed to grape-derived polyphenols, notably trans-resveratrol, present in red wine. It is not clear whether the cardioprotective effects of resverat...

journal_title：Biochemical and biophysical research communications

authors： Wang Z,Chen Y,Labinskyy N,Hsieh TC,Ungvari Z,Wu JM

更新日期：2006-07-21 00:00:00

abstract：:Direct chemical acetylation of an oligonucleosomal template for bacteriophage T7 RNA polymerase is accompanied by a substantial increase in its capability to support RNA synthesis. The template was assembled from a plasmid, containing a promoter and a terminator for T7 RNA polymerase, plus one (H3-H4)2 tetramer and tw...

journal_title：Biochemical and biophysical research communications

authors： Hernández F,Puerta C,López-Alarcón L,Palacián E

更新日期：1995-08-04 00:00:00

abstract：:Ischemic injury is a primary contributor to the initiation of renal tubular epithelial cell damage in sickle cell disease (SCD). In this study, we investigated the effects of bilateral ischemia-reperfusion injury, which is a common type of acute kidney injury (AKI), in male and female genetic mouse model of SCD. Bilat...

journal_title：Biochemical and biophysical research communications

authors： Park F,Soni H,Pressly JD,Adebiyi A

更新日期：2019-07-12 00:00:00

abstract：:We describe a method for the removal of endogenous troponin (Tn) complex from bundles of detergent-treated cardiac fibers. After 70 min treatment with cTnT-cTnI most of the endogenous Tn complex was removed from fiber bundles. Complete reconstitution of the Tn complex was achieved by reconstituting with cardiac tropon...

journal_title：Biochemical and biophysical research communications

authors： Chandra M,Kim JJ,Solaro RJ

更新日期：1999-09-16 00:00:00

abstract：:Simple polyesters derived from poly(ethylene glycol)s and alpha, omega-dicarboxylic acids exhibit a broad range of activity in disrupting phospholipid membranes. This activity has been analyzed by measuring the release of liposome-encapsulated 5(6)-carboxy-fluorescein (CF). Comparison with an analogous monomeric surfa...

journal_title：Biochemical and biophysical research communications

authors： Regen SL,Jayasuriya N,Fabianowski W

更新日期：1989-03-15 00:00:00

abstract：:Matrin 3, a nuclear matrix protein has potential (1) to withhold promiscuously edited RNAs within the nucleus in cooperation with p54(nrb) and PSF, (2) to mediate NMDA-induced neuronal death, and (3) to modulate promoter activity of genes proximal to matrix/scaffold attachment region (MAR/SAR). We identified a biparti...

journal_title：Biochemical and biophysical research communications

authors： Hisada-Ishii S,Ebihara M,Kobayashi N,Kitagawa Y

更新日期：2007-03-02 00:00:00

abstract：:Kinetic studies of the reduction of Pseudomonas aeruginosa ferricytochrome c551 by Fe(EDTA)2- have been made. The reaction was found to follow a second-order rate law: k 4.2 x 10(3) M(-1) s(-1) [25 degrees, micro0.1 M, pH 7.0 (phosphate)]; deltaH+/+ 3.2 kcal/ mol; AS+/+ -30 cal/mol-deg. The electrostatics-corrected se...

journal_title：Biochemical and biophysical research communications

authors： Coyle CL,Gray HB

更新日期：1976-12-20 00:00:00

abstract：:Using PAGE--Autoradioblotting technique we have characterized an E--FABP in human epidermal cells that is distinct from liver-, heart-, intestine- and adipose tissue-FABPs. FABP radiobinding analysis was performed directly on protein extracts without prior partial purification. E-FABP has a Mr of approximately 15 kDa ...

journal_title：Biochemical and biophysical research communications

authors： Siegenthaler G,Hotz R,Chatellard-Gruaz D,Jaconi S,Saurat JH

更新日期：1993-01-29 00:00:00

abstract：:To repair bone defects, we evaluate the in-vitro and in-vivo osteogenic activities of a novel tissue-engineered bone (TEB) by elaborately combining biomimetic calcium phosphate (BioCaP) granules with internally-incorporated simvastatin (SIM) and human adipose-derived stem cells (hASCs). First, we constructed BioCaP wi...

journal_title：Biochemical and biophysical research communications

authors： Zhang X,Jiang W,Liu Y,Zhang P,Wang L,Li W,Wu G,Ge Y,Zhou Y

更新日期：2018-01-01 00:00:00

abstract：:Proteoglycans (PGs) are complex glycohydrates, which are composed of core proteins and glycosaminoglycans and widely distributed in connective tissues and on the cell surface of mammalian tissues. We investigated the effect of PG extracted from salmon cartilage on cytokine responses to stimulation with heat-killed Esc...

journal_title：Biochemical and biophysical research communications

authors： Sashinami H,Takagaki K,Nakane A

更新日期：2006-12-29 00:00:00

abstract：:Intestinal N-acetylglucosamine 6-O-sulfotransferase (I-GlcNAc6ST, GST-4alpha) and corneal N-acetylglucosamine 6-O-sulfotransferases (C-GlcNAc6ST, GST-4beta) are two highly homologous GlcNAc 6-O-sulfotransferase isozymes encoded by two intronless open reading frames that reside approximately 50 kb apart on human chromo...

journal_title：Biochemical and biophysical research communications

authors： Bartes A,Bhakta S,Hemmerich S

更新日期：2001-04-13 00:00:00

abstract：:Prostaglandin (PG)E(2) is a critical lipid mediator connecting chronic inflammation to cancer. The anti-carcinogenic epigallocatechin-3-gallate (EGCG) from green tea (Camellia sinensis) suppresses cellular PGE(2) biosynthesis, but the underlying molecular mechanisms are unclear. Here, we investigated the interference ...

journal_title：Biochemical and biophysical research communications

authors： Koeberle A,Bauer J,Verhoff M,Hoffmann M,Northoff H,Werz O

更新日期：2009-10-16 00:00:00

abstract：:Strategies that antagonize growth factor signaling are attractive candidates for the biological therapy of brain tumors. HGF/NK2 is a secreted truncated splicing variant and potential antagonist of scatter factor/hepatocyte growth factor (SF/HGF), a multifunctional cytokine involved in the malignant progression of sol...

journal_title：Biochemical and biophysical research communications

authors： Guerin C,Luddy C,Abounader R,Lal B,Laterra J

更新日期：2000-06-24 00:00:00

abstract：:Human natural killer enhancing factor genes (NKEF-A and B) share extensive homology with several genes from other organisms known to be induced by oxidative stress and to protect organisms and proteins from oxidative destruction. In this study, we have identified natural killer enhancing factor as an abundant protein ...

journal_title：Biochemical and biophysical research communications

authors： Shau H,Kim A

更新日期：1994-02-28 00:00:00

abstract：:Rats were fed for 15 days a diet containing ammonium acetate (20% w/w) and then injected i. p. with ammonium acetate (7 mmol/Kg). Only 1 out of 18 control rats but 9 of 18 rats fed ammonium survived, indicating a protective effect of ammonium ingestion against an acute ammonia challenge. Blood ammonia returned to norm...

journal_title：Biochemical and biophysical research communications

authors： Miñana MD,Felipo V,Grisolía S

更新日期：1988-06-30 00:00:00

abstract：BACKGROUND AND AIM:Aberrant expression of miR-107 is involved in the development of several human cancers. However, the role of miR-107 in hepatocellular carcinoma (HCC) is not well documented. In the present study, we aim to explore the function of miR-107 in hepatocarcinogenesis. METHODS:Bioinformatics analysis was ...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Chen F,Zhao M,Yang Z,Zhang S,Ye L,Gao H,Zhang X

更新日期：2016-11-18 00:00:00