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Context-dependent role of ATG4B as target for autophagy inhibition in prostate cancer therapy.

Abstract：

:ATG4B belongs to the autophagin family of cysteine proteases required for autophagy, an emerging target of cancer therapy. Developing pharmacological ATG4B inhibitors is a very active area of research. However, detailed studies on the role of ATG4B during anticancer therapy are lacking. By analyzing PC-3 and C4-2 prostate cancer cells overexpressing dominant negative ATG4B(C74A)in vitro and in vivo, we show that the effects of ATG4B(C74A) are cell type, treatment, and context-dependent. ATG4B(C74A) expression can either amplify the effects of cytotoxic therapies or contribute to treatment resistance. Thus, the successful clinical application of ATG4B inhibitors will depend on finding predictive markers of response.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tran E,Chow A,Goda T,Wong A,Blakely K,Rocha M,Taeb S,Hoang VC,Liu SK,Emmenegger U

doi

10.1016/j.bbrc.2013.10.117

subject

Has Abstract

pub_date

2013-11-29 00:00:00

pages

726-31

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(13)01808-1

journal_volume

441

pub_type

杂志文章

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