Differential expression of cytochrome P-450 in proliferating and quiescent cultures of murine lung epithelial cells.

abstract：:In human platelets, the amounts of triphosphoinositides (TPI) and diphosphoinositides (DPI) increase after 30 sec and level off after 120 sec of thrombin stimulation. After 180 sec of thrombin challenge, TPI and DPI increase accounts for 66 and 80%, respectively. Polyphosphoinositide changes roughly parallel the relea...

journal_title：Biochemical and biophysical research communications

authors： Perret BP,Plantavid M,Chap H,Douste-Blazy L

更新日期：1983-01-27 00:00:00

abstract：:The effects of omeprazole on developing rat stomach mucosa were investigated. Infant rats were given subcutaneous injections of either omeprazole (25 mg/kg body weight/day) or vehicle once a day from the day after birth. As a result, omeprazole caused an elevation of mucosal pH and suppressed an increase in mucosal pe...

journal_title：Biochemical and biophysical research communications

authors： Kakei N,Ichinose M,Tsukada S,Tatematsu M,Tezuka N,Furihata C,Yahagi N,Matsushima M,Miki K,Kurokawa K

更新日期：1993-11-30 00:00:00

abstract：:Endothelin tightly bound to rabbit aortic strips and caused a prolonged vasoconstriction both in the presence and absence of extracellular Ca2+, although only partial constriction (20-30%) developed in the latter case, indicating that its action may not be limited to the opening of a calcium channel. The endothelin-in...

journal_title：Biochemical and biophysical research communications

authors： Sugiura M,Inagami T,Hare GM,Johns JA

更新日期：1989-01-16 00:00:00

abstract：:Activation of reactive oxygen and nitrogen species (RONS) by redox-active metal ions has been proposed to contribute to oxidative damage in inflamed tissues. Here, we report a dual-function anti-oxidant conjugate comprising an anti-inflammatory agent (5-aminosalicylic acid) and a chelator with potential as a superoxid...

journal_title：Biochemical and biophysical research communications

authors： Bailey MA,Ingram MJ,Naughton DP

更新日期：2004-05-14 00:00:00

abstract：:Cav1.2 (alpha1C) and Cav1.3 (alpha1D) L-type Ca channels are co-expressed in the heart. To date, there are no pharmacological or biophysical tools to separate alpha1D from alpha1C Ca currents (I(Ca-L)) in cardiomyocytes. Here, we established a physiological model to study alpha1D I(Ca-L) in native myocytes using RNA i...

journal_title：Biochemical and biophysical research communications

authors： Karnabi E,Qu Y,Mancarella S,Yue Y,Wadgaonkar R,Boutjdir M

更新日期：2009-07-10 00:00:00

abstract：:Subpeptin JM4-A and subpeptin JM4-B are two novel antimicrobial peptides produced by Bacillus subtilis JM4. To identify putative genes involved in their production, degenerate PCR primers targeted to conserved motifs of nonribosomal peptide synthetases (NRPSs) were used. A resulting 1.2 kb PCR product had high sequenc...

journal_title：Biochemical and biophysical research communications

authors： Wu S,Zhong J,Huan L

更新日期：2006-06-16 00:00:00

abstract：:Celiptium, a cationic and amphiphilic drug currently employed in cancer chemotherapy, was found to be accumulated against its concentration gradient by the bacterium Streptococcus pneumoniae. Accumulation was reduced in Celiptium resistant amiA mutants which were also observed to have reduced electric transmembrane po...

journal_title：Biochemical and biophysical research communications

authors： Sautereau AM,Tocanne JF,Trombe MC

更新日期：1987-06-15 00:00:00

abstract：:We previously reported that novel targeted "hybrid peptide" in which epidermal growth factor receptor (EGFR) binding peptide was conjugated with lytic-type peptide had selective cytotoxic activity to EGFR expressing cancer cell lines, and in vivo analysis revealed that this EGFR-lytic peptide displayed significant ant...

journal_title：Biochemical and biophysical research communications

authors： Tada N,Horibe T,Haramoto M,Ohara K,Kohno M,Kawakami K

更新日期：2011-04-08 00:00:00

abstract：:Thymoquinone (TQ), a component derived from the bioactive constituent of black seed (Nigella sativa), has been shown to exert biological activity on various types of human cancers. However, there are few studies addressing its effects on gastric cancer. Here, we present the first report describing the chemosensitizing...

journal_title：Biochemical and biophysical research communications

authors： Lei X,Lv X,Liu M,Yang Z,Ji M,Guo X,Dong W

更新日期：2012-01-13 00:00:00

abstract：:A procedure is described for preparation of homogeneous inositol monophosphate phosphatase (EC 3.1.3.25) from beef brain in less than 2 days with an overall recovery of 15-25%. This enzyme, an essential part of the inositol phospholipid cycle in brain, is a proposed site of action of lithium ions in manic-depressive d...

journal_title：Biochemical and biophysical research communications

authors： Meek JL,Rice TJ,Anton E

更新日期：1988-10-14 00:00:00

abstract：:Three mRNA species for human muscle phophofructokinase containing heterogeneous 5' untranslated sequences were identified through cDNA cloning. Type A mRNA was essentially the same as that reported previously (Nakajima, H., et al. (1987) FEBS Lett. 223, 113). Type B mRNA was considered to be the major gene product, wh...

journal_title：Biochemical and biophysical research communications

authors： Nakajima H,Yamasaki T,Noguchi T,Tanaka T,Kono N,Tarui S

更新日期：1990-01-30 00:00:00

abstract：:Tetrodotoxin-binding sites were covalently labelled with a highly tritiated derivative of tetrodotoxin. Cross-linking experiments, using dissucinimidyl suberate, on partially purified tetrodotoxin-binding component from electroplax of Electrophorus electricus, revealed covalent labelling of a single polypeptide chain ...

journal_title：Biochemical and biophysical research communications

authors： Lombet A,Norman RI,Lazdunski M

更新日期：1983-07-18 00:00:00

abstract：:Expression of TNF-alpha gene in the retinal pigment epithelial (RPE) cells was studied by using polymerase chain reaction (PCR). PCR for human TNF-alpha gene using complementary DNA (cDNA) of control RNA prepared from non-stimulated RPE cells failed to show expression of TNF-alpha gene. However, PCR by using cDNA prep...

journal_title：Biochemical and biophysical research communications

authors： Tanihara H,Yoshida M,Yoshimura N

更新日期：1992-09-16 00:00:00

abstract：:Several fusion proteins of mouse Interleukins (mILs) and the enhanced green fluorescent protein (EGFP) were expressed in fibroblast and epithelial cells. Among these proteins, the mIL-31 derivative was the most efficiently secreted into the medium in a N-glycosylation-dependent manner. From the analysis of deletion mu...

journal_title：Biochemical and biophysical research communications

authors： Akiyama N,Ohno Y,Fukuda T,Manome Y,Saito S

更新日期：2009-04-17 00:00:00

abstract：:Recent studies from our laboratory demonstrated that Egr-1 is upregulated in the rat duodenal mucosa during cysteamine-induced duodenal ulceration and that antisense egr-1 oligonucleotide aggravates the duodenal ulcers. This study was aimed to determine the effects of cysteamine on redox-sensitive Egr-1 transcriptiona...

journal_title：Biochemical and biophysical research communications

authors： Khomenko T,Deng X,Jadus MR,Szabo S

更新日期：2003-10-03 00:00:00

abstract：:Expression of the human beta-myosin heavy chain (beta MHC) gene was studied by transient assay in culture and in situ by direct injection of plasmids into adult rat hearts. In this report we describe a unique repressor region located -326/-309 (5'-TTGGTGGTCGTGGTCAGT-3') of the human beta MHC gene that is conserved amo...

journal_title：Biochemical and biophysical research communications

authors： Edwards JG,Bahl JJ,Flink I,Milavetz J,Goldman S,Morkin E

更新日期：1992-11-30 00:00:00

abstract：:Kidney microsomes from vitamin D-deficient rats and from thyroparathyroidectomized rats converted 25-hydroxyvitamin D3 to an unidentified metabolite. The addition of the cytosolic fraction enhanced microsomal synthesis of this metabolite two-fold. The kinetics of the conversion in the presence of the cytosolic fractio...

journal_title：Biochemical and biophysical research communications

authors： Thierry-Palmer M,Gray TK,Williams ME,Talmage RV

更新日期：1983-02-10 00:00:00

abstract：:Dysregulation of the receptor tyrosine kinase Axl and its ligand Gas6 has been shown to promote multiple tumorigenic processes, as well as to correlate with worse prognosis in many different tumor types. However, studies of Axl expression and function in osteosarcoma have rarely been reported. In this study, we report...

journal_title：Biochemical and biophysical research communications

authors： Han J,Tian R,Yong B,Luo C,Tan P,Shen J,Peng T

更新日期：2013-06-07 00:00:00

abstract：:p70 S6 kinase (p70 S6k) is important in regulating a variety of cellular functions including mRNA translation and cell cycle progression and is activated by mitogens and hormones. Unexpectedly, we have found that, in adult rat cardiomyocytes, arsenite, which generally induces stress responses, markedly and rapidly act...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Proud CG

更新日期：1997-09-08 00:00:00

abstract：:Chorea-acanthocytosis (ChAc) is a hereditary neurodegenerative disorder caused by loss of function mutations in the VPS13A gene encoding chorein. Recently, using a gene-targeting technique to delete exons 60-61, we produced a ChAc-model mouse that corresponds to a human disease mutation. In this study, a comparative m...

journal_title：Biochemical and biophysical research communications

authors： Kurano Y,Nakamura M,Ichiba M,Matsuda M,Mizuno E,Kato M,Izumo S,Sano A

更新日期：2006-12-15 00:00:00

abstract：:Combined-modality treatment has improved the outcome in cases of various solid tumors, and radiosensitizers are used to enhance the radiotherapeutic efficiency. Rosiglitazone, a synthetic ligand of peroxisome proliferator-activated receptors gamma used in the treatment of type-2 diabetes, has been shown to reduce tumo...

journal_title：Biochemical and biophysical research communications

authors： Chiu SJ,Hsaio CH,Tseng HH,Su YH,Shih WL,Lee JW,Chuah JQ

更新日期：2010-04-09 00:00:00

abstract：:The vasculo-toxic effect of meglumine antimoniate (MA) was confirmed in our previous investigation. The current study investigates the association of this effect with altered VEGF-A and VEGF-R2 expression. Additional mechanisms by which MA causes vascular toxicity are not clearly understood. We hypothesized that MA ma...

journal_title：Biochemical and biophysical research communications

authors： Khosravi A,Sharifi I,Tavakkoli H,Keyhani AR,Afgar A,Salari Z,Mosallanejad SS,Bamorovat M,Sharifi F,Hassanzadeh S,Sadeghi B,Dabiri S,Mortazaeizdeh A,Sheikhshoaie Z,Salarkia E

更新日期：2018-11-02 00:00:00

abstract：:Novel conformation-specific antibodies were raised against a cyclic chimeric dodecapeptidyl multiple antigen peptide (cCD-MAP) constructed with a spacer-armed Gly-Asp dipeptide and two pentapeptides (S(169)-Q(170)-K(171)-E(172)-G(173) of CCR5 and E(179)-A(180)-D(181)-D(182)-R(183) of CXCR4) which are components of the...

journal_title：Biochemical and biophysical research communications

authors： Misumi S,Takamune N,Ido Y,Hayashi S,Endo M,Mukai R,Tachibana K,Umeda M,Shoji S

更新日期：2001-08-03 00:00:00

abstract：:We have extracted and purified proteins from calcium containing urinary stones with 4 M guanidine chloride and sequenced the amino acids of the proteins. The protein of approximately 49kDa was defined as human alpha-one antitrypsin (AT, from 23rd to 42nd amino acids of NH2-terminal) by amino acid sequence analysis. Th...

journal_title：Biochemical and biophysical research communications

authors： Umekawa T,Kohri K,Amasaki N,Yamate T,Yoshida K,Yamamoto K,Suzuki Y,Sinohara H,Kurita T

更新日期：1993-06-30 00:00:00

abstract：:Oxidative damage to DNA has been reported to occur in a wide variety of disease states. The most widely used "marker" for oxidative DNA damage is 8-hydroxyguanine. However, the use of only one marker has limitations. Exposure of calf thymus DNA to an .OH-generating system (CuCl(2), ascorbate, H(2)O(2)) or to hypochlor...

journal_title：Biochemical and biophysical research communications

authors： Whiteman M,Hong HS,Jenner A,Halliwell B

更新日期：2002-08-30 00:00:00

abstract：:Helicobacter pylori is a bacterium that causes chronic active gastritis and peptic ulcers. Drugs targeting H. pylori phosphopantetheine adenylyltransferase (HpPPAT), which is involved in CoA biosynthesis, may be useful. Herein, we report the expression in Escherichia coli and purification of recombinant HpPPAT and des...

journal_title：Biochemical and biophysical research communications

authors： Cheng CS,Chen CH,Luo YC,Chen WT,Chang SY,Lyu PC,Kao MC,Yin HS

更新日期：2011-05-06 00:00:00

abstract：:Tamoxifen, a widely used nonsteroidal antiestrogen in the treatment of breast cancer, forms several metabolites. 4-Hydroxytamoxifen (4-OHTam), a metabolite found in the bloodstream, has much higher affinity for the estrogen receptor than tamoxifen itself. Oxidative activation of 4-OHTam induces DNA damage. DNA isolate...

journal_title：Biochemical and biophysical research communications

authors： Sharma M

更新日期：2000-06-24 00:00:00

abstract：:Chemerin is a chemoattractant cytokine (chemokine) produced by adipocytes and hepatocytes; it regulates insulin sensitivity and adipocyte differentiation. The objective of this study was to investigate the effect of chemerin on the expression of genes related to lactogenesis and the regulators of chemerin signaling in...

journal_title：Biochemical and biophysical research communications

authors： Suzuki Y,Haga S,Katoh D,So KH,Choi KC,Jung US,Lee HG,Katoh K,Roh SG

更新日期：2015-10-23 00:00:00

abstract：:Rat serosal mast cells were tested for their ability to generate a nitric oxide-like factor by two bioassay systems: inhibition of platelet aggregation and stimulation of mast cell guanylate cyclase. Incubation of rat serosal mast cells with human washed platelets resulted in an inhibition of thrombin-induced platelet...

journal_title：Biochemical and biophysical research communications

authors： Salvemini D,Masini E,Anggard E,Mannaioni PF,Vane J

更新日期：1990-06-15 00:00:00

abstract：:We cloned and sequenced a full-length cDNA of human placental N-acetylgalactosamine-6-sulfate sulfatase, the enzyme deficient in Morquio disease. The 2339-nucleotide sequence contained 1566 nucleotides which encoded a polypeptide of 522 amino acid residues. The deduced amino acid sequence was composed of a 26-amino ac...

journal_title：Biochemical and biophysical research communications

authors： Tomatsu S,Fukuda S,Masue M,Sukegawa K,Fukao T,Yamagishi A,Hori T,Iwata H,Ogawa T,Nakashima Y

更新日期：1991-12-16 00:00:00