当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Genetics of subpeptin JM4-A and subpeptin JM4-B production by Bacillus subtilis JM4.

Genetics of subpeptin JM4-A and subpeptin JM4-B production by Bacillus subtilis JM4.

Abstract：

:Subpeptin JM4-A and subpeptin JM4-B are two novel antimicrobial peptides produced by Bacillus subtilis JM4. To identify putative genes involved in their production, degenerate PCR primers targeted to conserved motifs of nonribosomal peptide synthetases (NRPSs) were used. A resulting 1.2 kb PCR product had high sequence similarity to genes of NRPSs, and then a 2.8 kb DNA fragment flanking it was cloned subsequently. Gene disruption of the resulting 4 kb DNA fragment produced subpeptin-deficient mutant, suggesting that subpeptin JM4-A and subpeptin JM4-B were biosynthesized by NRPSs. Based on this result, a 48 kb gene cluster was cloned, which consisted of nine coding sequences (CDSs) involved in antimicrobial peptide biosynthesis, regulation, and resistance. Disruption of two relatively large CDSs subA and subC led to subpeptin-deficient mutants, which supported the involvement of the cloned gene cluster in subpeptin biosynthesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wu S,Zhong J,Huan L

doi

10.1016/j.bbrc.2006.04.022

subject

Has Abstract

pub_date

2006-06-16 00:00:00

pages

1147-54

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)00828-X

journal_volume

344

pub_type

杂志文章

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