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Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosis.

Abstract：

:Streptococcus pneumoniae is a major pathogen of community-acquired pneumonia and one of its major virulence factors is pneumolysin, which functions as a cholesterol-dependent cytolytic pore-forming toxin. In this study, we identified the ply-like gene spd0729 in a BLAST search. Unexpectedly, hemolytic and cytotoxic assays showed no significant differences between a Deltaspd0729 mutant strain and the wild-type strain, whereas the mutant strain exhibited weaker anti-phagocytic activity in human peripheral blood. In addition, real-time RT-PCR analysis revealed that four capsular biosynthesis genes in the mutant strain had expressions 7- to 432-fold greater than those of the wild type, while an enzyme-linked immunoassay showed a mean 3-fold greater amount of total capsular polysaccharide in the mutant strain. These results suggest that Spd0729 is not a cytolysin, though it plays crucial roles in anti-phagocytosis and regulation of capsule expression. Thus, we named Spd0729 as a negative regulator of capsular polysaccharide synthesis (Nrc).

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yamaguchi M,Minamide Y,Terao Y,Isoda R,Ogawa T,Yokota S,Hamada S,Kawabata S

doi

10.1016/j.bbrc.2009.09.099

subject

Has Abstract

pub_date

2009-12-04 00:00:00

pages

155-60

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)01916-0

journal_volume

390

pub_type

杂志文章

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