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Omega-3 free fatty acids inhibit tamoxifen-induced cell apoptosis.

Abstract：

:Fish oil, which contains omega-3 fatty acids mainly in the form of triglycerides, has benefits for reducing breast cancer risk, similar to tamoxifen action. However, it remains to be elucidated whether the combination of omega-3 free fatty acid (ω-3FFA) with tamoxifen leads to improved treatment in breast cancer. In this study, we observed that ω-3FFA induces MCF-7 cell apoptosis to suppress cell growth. The treatment of breast cancer cells with ω-3FFA attenuated tamoxifen-induced cell apoptosis. ω-3FFA and tamoxifen significantly increased Erk1/2 and Akt phosphorylation levels in a dose and time dependent manner. Compared to ω-3FFA alone, the combination of tamoxifen with ω-3FFA significantly increased Erk1/2 and Akt phosphorylation levels. Because Erk1/2 and Akt activation has been linked to tamoxifen-related anti-estrogen resistance in breast cancer patients, these results indicate that ω-3FFA may interfere with the effects of tamoxifen in the prevention of breast cancer risk.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wu S,Guo Y,Wu Y,Zhu S,He Z,Chen YQ

doi

10.1016/j.bbrc.2015.02.103

subject

Has Abstract

pub_date

2015-04-03 00:00:00

pages

294-299

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)00343-5

journal_volume

459

pub_type

杂志文章

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