The activation of cAMP-dependent protein kinase is directly linked to the regulation of osteoblast proliferation (UMR-106) by parathyroid hormone.

abstract：:Five different receptor subtypes for neuropeptide Y (NPY) have recently been cloned in mammals. We have discovered three distinct subtypes by PCR in the zebrafish, Danio rerio, and describe here one of these called zYc. The protein sequence identity is 46-51% to mammalian subtypes Y1, Y4 and Y6 and to zebrafish Ya, i....

journal_title：Biochemical and biophysical research communications

authors： Ringvall M,Berglund MM,Larhammar D

更新日期：1997-12-29 00:00:00

abstract：:Until today, 14 isoforms of mammalian calpains have been identified, including calpain-5. The C. elegans calpain-5 homologue tra-3 is reported to be essential for necrotic neuronal cell death. In this study, we cloned and characterized rat calpain-5, which is highly homologous to human and mouse sequences. The nucleot...

journal_title：Biochemical and biophysical research communications

authors： Waghray A,Wang DS,McKinsey D,Hayes RL,Wang KK

更新日期：2004-11-05 00:00:00

abstract：:G13 belongs to the G12-subfamily of heterotrimeric regulatory G-proteins. Employing specific antibodies, we isolated G alpha 13 from bovine brain by a four-step purification protocol combining conventional and affinity chromatography. The use of ethylene glycol as a protective agent influenced the elution properties o...

journal_title：Biochemical and biophysical research communications

authors： Harhammer R,Nürnberg B,Spicher K,Schultz G

更新日期：1994-10-28 00:00:00

abstract：:Quantitative and qualitative analyses of mRNAs from a small number of cells are extremely important for studies on gene expression in various physiological and pathological conditions in multicellular organisms. We present here an effective method for high-fidelity global mRNA amplification for in vivo gene expression...

journal_title：Biochemical and biophysical research communications

authors： Aoyagi K,Tatsuta T,Nishigaki M,Akimoto S,Tanabe C,Omoto Y,Hayashi Si,Sakamoto H,Sakamoto M,Yoshida T,Terada M,Sasaki H

更新日期：2003-01-24 00:00:00

abstract：:Alisol B-23-acetate (AB23A), a tetracyclic triterpenoid isolated from the rhizome of Alisma orientale, has been reported to exert anti-proliferative activities in human colon, ovarian and gastric cancer cells. However, the anti-cancer effect of this compound on human lung cancer cells has not yet been thoroughly eluci...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Li H,Wang X,Shen T,Wang S,Ren D

更新日期：2018-11-10 00:00:00

abstract：:Proteins with expanded polyglutamine domains cause eight inherited neurodegenerative diseases including Huntington's disease. In a previous paper, we identified peptides that inhibit polyglutamine protein aggregation and cell death and now describe the amino acid sequence requirements necessary for these activities. T...

journal_title：Biochemical and biophysical research communications

authors： Ren H,Nagai Y,Tucker T,Strittmatter WJ,Burke JR

更新日期：2001-11-02 00:00:00

abstract：:The human dopamine D4 receptor gene (DRD4) is an important candidate gene for schizophrenia. We identified a novel -521C>T polymorphism in the 5'-promoter region of DRD4. A transient expression method revealed that the T allele of this polymorphism reduces the transcriptional efficiency by 40% compared with the C alle...

journal_title：Biochemical and biophysical research communications

authors： Okuyama Y,Ishiguro H,Toru M,Arinami T

更新日期：1999-05-10 00:00:00

abstract：:In a number of cell lines responsive to basic fibroblast growth factor (bFGF), two major tyrosine phosphorylated proteins, of molecular weights around 120kDa and 90kDa, are precipitated along with the tyrosine phosphatase SHP2 from the lysates of stimulated cells. The docker protein Gab-1 represents at least part of t...

journal_title：Biochemical and biophysical research communications

authors： Ong SH,Lim YP,Low BC,Guy GR

更新日期：1997-09-08 00:00:00

abstract：:Previous studies have shown that DNA strand breaks are an early consequence of nitric oxide toxicity in pancreatic islet cells. We show here that exposure of islet cells to chemical NO donors causes the formation of ADP-ribose polymers in cell nuclei, with concomitant depletion of intracellular NAD+. Islet cell lysis ...

journal_title：Biochemical and biophysical research communications

authors： Radons J,Heller B,Bürkle A,Hartmann B,Rodriguez ML,Kröncke KD,Burkart V,Kolb H

更新日期：1994-03-30 00:00:00

abstract：:Multidrug-resistant cells are characterized by the presence of P-glycoprotein on the plasma membrane, which binds and probably transports antitumor agents outside the cells. P-glycoprotein is also present in various normal tissues such as the adrenal gland. To investigate the physiological function of P-glycoprotein, ...

journal_title：Biochemical and biophysical research communications

authors： Naito M,Yusa K,Tsuruo T

更新日期：1989-02-15 00:00:00

abstract：:The phosphorylation status of the cardiac sarcoplasmic reticular (SR) protein phospholamban determines the activity of the SR Ca(2+)-ATPase. In order to predict SR Ca2+ transport in vivo, it is vital that techniques used to measure the phosphorylation status of phospholamban adequately clamp the endogenous kinases and...

journal_title：Biochemical and biophysical research communications

authors： Calaghan S,White E,Colyer J

更新日期：1998-07-30 00:00:00

abstract：:Interleukin-10 (IL-10) is a cytokine with many regulatory functions. In particular, IL-10 exerts neutralizing effect on other cytokines, and therefore IL-10 is thought to have important therapeutic implications. Recent reports suggest that IL-10 regulates not only immunocytes but also collagen and collagenase gene exp...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto T,Eckes B,Krieg T

更新日期：2001-02-16 00:00:00

abstract：:The fusion of myoblasts to myotubes requires an endogenous soluble metalloendoprotease. To determine whether this protease is released by fusing myoblasts, or stays within the cell, we examined the effects of membrane-impermeant and a membrane-permeant metalloendoprotease inhibitors. Membrane-permeant 1,10-phenanthrol...

journal_title：Biochemical and biophysical research communications

authors： Farach HA Jr,Strittmatter WJ

更新日期：1987-08-31 00:00:00

abstract：:Glucocorticoid receptors (GRs) are extensively studied members of the steroid hormone receptor superfamily that regulate the transcription rates of numerous genes. Notwithstanding, the role of each GR amino acid in the various steps of transactivation is still unknown. A recent report shows that linear DNA has the sam...

journal_title：Biochemical and biophysical research communications

authors： Chen J,Blackford JA Jr,Simons SS Jr

更新日期：2004-09-03 00:00:00

abstract：:Chlamydia trachomatis (C. trachomatis) is an obligate intracellular organism that depends on nutrients from the host cell for their replication and proliferation. Therefore, the interaction between this pathogen and host induces sustained endoplasmic reticulum (ER) stress in the infected cells. Unfolded protein respon...

journal_title：Biochemical and biophysical research communications

authors： Wen Y,Luo F,Zhao Y,Su S,Shu M,Li Z

更新日期：2020-06-30 00:00:00

abstract：:We have identified two types of homologous DNA pairing activity in mouse cell extracts by a strand-transfer assay. Both activities are separated from each other by anion-exchange chromatography; neither of them needs ATP. One requires magnesium ion and is stimulated by Escherichia coli single-stranded DNA binding prot...

journal_title：Biochemical and biophysical research communications

authors： Mishina Y,Shimokawa T,Kawasaki K,Arai N,Shibata T,Koyama H

更新日期：1992-06-30 00:00:00

abstract：:The molecular mechanisms by which chronic hypoxia, whether constant (CCH) or intermittent (CIH), alters the heart rhythm are still under debate. Expression level, control, maturational profile and intercoordination of 54 genes encoding heart rhythm determinants (HRDs) were analyzed in 36 mice subjected for 1, 2 or 4 w...

journal_title：Biochemical and biophysical research communications

authors： Iacobas DA,Iacobas S,Haddad GG

更新日期：2010-01-22 00:00:00

abstract：:A calcium-calmodulin (Ca2(+)-CaM) stimulated histone H3 phosphorylating activity was identified as a component of a nuclear protein complex purified from a 150 mM NaCl extract of calf thymus chromatin. This activity bound to a CaM-Sepharose affinity column in a Ca2+ dependent manner and was eluted off the column in th...

journal_title：Biochemical and biophysical research communications

authors： Wakim BT,Picken MM,DeLange RJ

更新日期：1990-08-31 00:00:00

abstract：BACKGROUND:During implantation, the blastocyst trophectoderm attaches to the endometrial epithelium and continues to differentiate into all trophoblast subtypes, which are the major components of a placenta. Aberrant trophoblast proliferation and differentiation are associated with placental diseases. However, due to e...

journal_title：Biochemical and biophysical research communications

authors： Chen Y,Wang K,Chandramouli GV,Knott JG,Leach R

更新日期：2013-07-12 00:00:00

abstract：:Apoptosis and autophagy are crucial mechanisms regulating cell death, and the relationship between apoptosis and autophagy in the liver has yet to be thoroughly explored. TIGAR (TP53-induced glycolysis and apoptosis regulator), which is a p53-inducible gene, functions in the suppression of ROS (reactive oxygen species...

journal_title：Biochemical and biophysical research communications

authors： Ye L,Zhao X,Lu J,Qian G,Zheng JC,Ge S

更新日期：2013-07-26 00:00:00

abstract：:Thrombin induced tyrosine phosphorylation of 41-kDa and 43-kDa mitogen-activated protein (MAP) kinases in human platelets which was detectable at 1 min and peaked at 2 min after thrombin stimulation as assessed by immunoprecipitation and immunoblotting. The kinase activity, measured by phosphorylation of myelin basic ...

journal_title：Biochemical and biophysical research communications

authors： Nakashima S,Chatani Y,Nakamura M,Miyoshi N,Kohno M,Nozawa Y

更新日期：1994-01-28 00:00:00

abstract：:Oxidative stress plays a key role in the pathogenesis of diabetic nephropathy (DN). The anti-aging protein Klotho has been demonstrated to have antioxidant capacity. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating antioxidant responses. The present study aimed to explore...

journal_title：Biochemical and biophysical research communications

authors： Xing L,Guo H,Meng S,Zhu B,Fang J,Huang J,Chen J,Wang Y,Wang L,Yao X,Wang H

更新日期：2021-01-01 00:00:00

abstract：:The C-terminus of Hsp70 interacting protein (CHIP) is being considered to be a cellular quality control E3 ubiquitin ligase because of its ability to degrade misfolded proteins in association with heat shock chaperones. The neuroprotective role of CHIP also has been implicated in several familial neurodegenerative dis...

journal_title：Biochemical and biophysical research communications

authors： Dikshit P,Jana NR

更新日期：2007-06-08 00:00:00

abstract：:The effect of nicotinamide and flavin coenzymes on the 5-lipoxygenase activity has been determined in cell-free extracts from rat polymorphonuclear leukocytes. 5-lipoxygenase was assayed in the presence of 5-hydroperoxyeicosatetraenoic acid (5-HPETE), which caused a 3 to 4-fold stimulation in the maximal conversion of...

journal_title：Biochemical and biophysical research communications

authors： Riendeau D,Leblanc Y

更新日期：1986-12-15 00:00:00

abstract：:Lysophosphatidic acid (LPA), an extracellular lipid mediator, exerts various cellular effects through activation of LPA receptors, LPA1-LPA6, in many types of cells including cancer cells. We recently found several missense mutations of Lpar1 in rat cancer tissues. One of these mutations is located at the extracellula...

journal_title：Biochemical and biophysical research communications

authors： Ishii S,Tsujiuchi T,Fukushima N

更新日期：2017-05-06 00:00:00

abstract：:Neuroblastoma (NB) expresses the tyrosine kinase receptors c-Kit, PDGFR-alpha and -beta-targets for STI-571. We investigated a possible combination therapy of STI-571 with retinoic acid (RA) and gamma-irradiation on NB cell viability in vitro. Expression of tyrosine kinase receptors and their ligands was examined in 6...

journal_title：Biochemical and biophysical research communications

authors： Rössler J,Zambrzycka I,Lagodny J,Kontny U,Niemeyer CM

更新日期：2006-04-21 00:00:00

abstract：:Parathyroid hormone (PTH) has a central role in the regulation of serum calcium and phosphate, while parathyroid hormone-related peptide (PTHrP) has important developmental roles. Both peptides signal through the same receptor, the PTH/PTHrP receptor (a class B G-protein-coupled receptor). The different biological eff...

journal_title：Biochemical and biophysical research communications

authors： Gensure RC,Gardella TJ,Jüppner H

更新日期：2005-03-18 00:00:00

abstract：:Wnt/beta-catenin signaling plays an important role not only in cancer, but also in cancer stem cells. In this study, we found that beta-catenin and OCT-4 was highly expressed in cisplatin (DDP) selected A549 cells. Stimulating A549 cells with lithium chloride (LiCl) resulted in accumulation of beta-catenin and up-regu...

journal_title：Biochemical and biophysical research communications

authors： Teng Y,Wang X,Wang Y,Ma D

更新日期：2010-02-12 00:00:00

abstract：:Acute lung injury (ALI) is a severe clinical condition with high morbidity and mortality. Apoptosis is a key pathologic feature of ALI, and Bcl-2 plays an important role during the pathogenesis of ALI via the regulation of apoptosis. However, the regulation of Bcl-2 during ALI, particularly through microRNAs, remains ...

journal_title：Biochemical and biophysical research communications

authors： Zhao J,Li X,Zou M,He J,Han Y,Wu D,Yang H,Wu J

更新日期：2014-10-03 00:00:00

abstract：:The conformational dependence of the interresidue interproton distances in peptides, C alpha H ... Ni + 1 H and NiH ... Ni + 1 H, have been used to identify zones of sterically allowed phi, psi space, where both distances are less than 3A and expected to yield nuclear Overhauser effects (NOEs). L-residues in left-hand...

journal_title：Biochemical and biophysical research communications

authors： Ramakrishnan C,Sukumar M,Balaram P

更新日期：1987-12-31 00:00:00