SECReT of the eukaryotic large ribosomal subunit.

abstract：:aDNA extraction and amplification procedures have been optimized for Pompeian human bone remains whose diagenesis has been determined by histological analysis. Single copy genes amplification (X and Y amelogenin loci and Y specific alphoid repeat sequences) have been performed and compared with anthropometric data on ...

journal_title：Biochemical and biophysical research communications

authors： Cipollaro M,Di Bernardo G,Galano G,Galderisi U,Guarino F,Angelini F,Cascino A

更新日期：1998-06-29 00:00:00

abstract：:Glutaredoxin 3 (GLRX3) is a member of monothiol glutaredoxins with a CGFS active site that has been demonstrated to function in cellular iron sensing and trafficking via its bound iron-sulfur cluster. Human GLRX3 has been shown to form a dimer that binds two bridging [2Fe-2S] clusters with glutathione (GSH) as a ligan...

journal_title：Biochemical and biophysical research communications

authors： Xia H,Li B,Zhang Z,Wang Q,Qiao T,Li K

更新日期：2015-09-25 00:00:00

abstract：:The P-type ATPases affected in Menkes and Wilson diseases, ATP7A and ATP7B, respectively, are key copper transporters that regulate copper homeostasis. The N termini of these proteins are critical in regulating their function and activity, and contain six copper-binding motifs MxCxxC. In this study, we describe the id...

journal_title：Biochemical and biophysical research communications

authors： Lim CM,Cater MA,Mercer JF,La Fontaine S

更新日期：2006-09-22 00:00:00

abstract：:The Notch3 N-terminal sequence is conserved across several mammalian species but diverges from the three other Notch proteins. We determined the significance of the N-terminal sequence using deletion mutants. The first 39 amino acids are required for Notch3 receptor expression, processing, and functional activity. In ...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Jia L,Lee SJ,Wang MM

更新日期：2007-03-30 00:00:00

abstract：:The integrity and the surface charge distribution of native low density lipoprotein (LDL) are prerequisites of its binding to the LDL receptor. Oxidation is one of the most important physiological effects resulting in an altered structure and metabolism of LDL. To reveal forces responsible for maintaining the intact s...

journal_title：Biochemical and biophysical research communications

authors： Lakatos S,Fürész J,Pállinger E,Rischák K,Schweitzer K,Szollár L

更新日期：1995-11-02 00:00:00

abstract：:Selected purinoceptor modulators were previously shown to prevent glutamate-evoked cytotoxicity in cerebellar granule neurons. In the same cellular system, we now identify and characterize the presence of P2 receptors. The binding of [3H]ATP to membranes of cerebellar granule neurons grows monotonically as a function ...

journal_title：Biochemical and biophysical research communications

authors： Merlo D,Volonté C

更新日期：1996-08-23 00:00:00

abstract：:Fas-associated protein with death domain (FADD) has been implicated in T lymphocytes, but the nature of FADD-dependent mechanism in early T cell development has not been completely elucidated. In this study, using T-cell specific deletion mice, we observed that FADD deficiency in thymocytes led to increased apoptosis ...

journal_title：Biochemical and biophysical research communications

authors： Zhang XY,Yang BY,Wang JY,Mo X,Zhang J,Hua ZC

更新日期：2014-08-22 00:00:00

abstract：:There is increasing evidence to suggest that Ca2+-calmodulin dependent protein kinase (CaMK) regulates the sarcoplasmic reticulum (SR) function and thus plays an important role in modulating the cardiac performance. Because intracellular Ca2+-overload is an important factor underlying cardiac dysfunction in a heart di...

journal_title：Biochemical and biophysical research communications

authors： Netticadan T,Temsah RM,Kawabata K,Dhalla NS

更新日期：2002-05-03 00:00:00

abstract：:Macroautophagy (autophagy) is an intracellular catalytic process. We examined the effect of running exercise, which stimulates cardiac work physiologically, on the expression of microtubule-associated protein 1 light chain 3 (LC3)-II, an indicator of autophagy, as well as some autophagy-related proteins in rat cardiac...

journal_title：Biochemical and biophysical research communications

authors： Ogura Y,Iemitsu M,Naito H,Kakigi R,Kakehashi C,Maeda S,Akema T

更新日期：2011-11-04 00:00:00

abstract：:Bone is a rigid yet dynamic organ, and this dynamism is mediated by the delicate balance between osteoclastic bone resorption and osteoblastic bone formation. However, excessive activation of osteoclasts is responsible for many bone diseases such as osteoporosis, Paget disease, and tumor bone metastasis. Agents that c...

journal_title：Biochemical and biophysical research communications

authors： Zhou F,Shen Y,Liu B,Chen X,Wan L,Peng D

更新日期：2017-03-18 00:00:00

abstract：:The protein kinase C inhibitor C-I reduced superoxide production by human neutrophils in response to phorbol myristate acetate by greater than 50%. In contrast to its effects in oxidative metabolism, 100 microM C-I caused minimal inhibition (5-18%) of lysozyme release in response to phorbol myristate acetate. Enzyme r...

journal_title：Biochemical and biophysical research communications

authors： Salzer W,Gerard C,McCall C

更新日期：1987-10-29 00:00:00

abstract：:Arginine kinase catalyzes the reversible transfer of a phosphoryl group between ATP and l-arginine and is a monomeric homolog of the human enzyme creatine kinase. Arginine and creatine kinases belongs to the phosphagen kinase family of enzymes, which consists of eight known members, each of which is specific for its o...

journal_title：Biochemical and biophysical research communications

authors： Clark SA,Davulcu O,Chapman MS

更新日期：2012-10-12 00:00:00

abstract：:The decomposition of peroxynitrite in the presence of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) generated 5,5-dimethylpyrrolidone-(2)-oxy-(1) (DMPOX) without formation of DMPO/OH. Formate enhanced the peroxynitrite decomposition but did not generate any detectable amount of formate-derived free radicals. Glutathione, cy...

journal_title：Biochemical and biophysical research communications

authors： Shi X,Lenhart A,Mao Y

更新日期：1994-09-30 00:00:00

abstract：:A rapid and easy method for the production of both the 4R and 4S tritium labeled isomers of either NADH or NADPH has been developed. The method requires the use of only a single labeled compound (D-[1(-3)H] glucose), and two enzymes (glucose dehydrogenase from Bacillus sp. and alcohol dehydrogenase from Thermoanaerobi...

journal_title：Biochemical and biophysical research communications

authors： Valera V,Fung M,Wessler AN,Richards WR

更新日期：1987-10-14 00:00:00

abstract：:Triple A syndrome is an autosomal recessive neurological disease, mimicking motor neuron disease, and is caused by mutant ALADIN, a nuclear-pore complex component. We recently discovered that the pathogenesis involved impaired nuclear import of DNA repair proteins, including DNA ligase I and the cerebellar ataxia caus...

journal_title：Biochemical and biophysical research communications

authors： Kiriyama T,Hirano M,Asai H,Ikeda M,Furiya Y,Ueno S

更新日期：2008-10-03 00:00:00

abstract：:As studied by intravital microscopy, local challenge with the mast cell secretagogue compound 48/80 was found to increase the leukocyte rolling fraction, decrease rolling velocity and induce firm leukocyte adhesion in postcapillary venules of the rat mesentery. These effects of compound 48/80 were inhibited by a monoc...

journal_title：Biochemical and biophysical research communications

authors： Thorlacius H,Raud J,Rosengren-Beezley S,Forrest MJ,Hedqvist P,Lindbom L

更新日期：1994-09-15 00:00:00

abstract：:The biological significance of isoprenoid compounds such as ubiquinones, prenols and sterols have been well established. The presence and biological function of the two quinones Q6 and Q8 in the cattle filarial parasite Setaria digitata have already been reported. Inhibition of the function of quinone was already show...

journal_title：Biochemical and biophysical research communications

authors： Kumari GA,Santhamma KR,Raj RK

更新日期：1994-11-30 00:00:00

abstract：:In this study we examined the influence on AlF4- and GTP gamma S on amylase secretion from alpha toxin permeabilized pancreatic acini. AlF4- only activates heterotrimeric G-proteins, whereas GTP gamma S activates both small ras-like GTP-binding proteins and heterotrimeric G-proteins (Kahn, R. A., J. Biol. Chem., 266, ...

journal_title：Biochemical and biophysical research communications

authors： Padfield PJ,Panesar N

更新日期：1998-04-17 00:00:00

abstract：:The effects of a synthetic protein kinase C (PKC) activator, (-)-indolactam V (ILV), were studied in SH-SY5Y human neuroblastoma cells. (-)-ILV induced a translocation of PKC from cytosol to plasma membrane and displaced 3H-phorbol dibutyrate binding in the micromolar range. In addition, (-)-ILV caused a decreased sen...

journal_title：Biochemical and biophysical research communications

authors： Heikkilä J,Akerman KE

更新日期：1989-08-15 00:00:00

abstract：:Amyloid β (Aβ) oligomers may be a real culprit in the pathogenesis of Alzheimer's disease (AD); therefore, the elimination of these toxic oligomers may be of great significance for AD therapy. Autophagy is the catabolic process by which lysosomes degrade cytosolic components, and heat shock cognate 70 kDa protein (Hsc...

journal_title：Biochemical and biophysical research communications

authors： Dou J,Su P,Xu C,Wen Z,Mao Z,Li W

更新日期：2020-04-16 00:00:00

abstract：:An in organello footprinting approach has been used to probe a protein-DNA interaction of a nuclear coded 25 kDa protein, previously isolated in our laboratory, that binds "in vitro" a region within the ND2 gene, located upstream of the Ori-L. Footprinting studies with the purine-modifying reagent dimethyl sulfate and...

journal_title：Biochemical and biophysical research communications

authors： Cingolani G,Capaccio L,D'Elia D,Gadaleta G

更新日期：1997-02-24 00:00:00

abstract：:Epidemiologic studies suggest that low to moderate consumption of red wine is inversely associated with the risk of coronary heart disease; the protection is in part attributed to grape-derived polyphenols, notably trans-resveratrol, present in red wine. It is not clear whether the cardioprotective effects of resverat...

journal_title：Biochemical and biophysical research communications

authors： Wang Z,Chen Y,Labinskyy N,Hsieh TC,Ungvari Z,Wu JM

更新日期：2006-07-21 00:00:00

abstract：:MOTS-c, as a mitochondria derived peptide, exerts benefits for insulin resistance in HFD mice and against various stresses in an AMPK dependent way. Here, in the D-galactose chronic injection models, exogenous MOTS-c was given to determine its direct anti-aging effects. The body weight, insulin sensitivity and blood g...

journal_title：Biochemical and biophysical research communications

authors： Li Q,Lu H,Hu G,Ye Z,Zhai D,Yan Z,Wang L,Xiang A,Lu Z

更新日期：2019-05-28 00:00:00

abstract：:The characterization of a 20 kilodalton (20 kD) variant of rat growth hormone is reported. The 20 kD variant from rat pituitary gland extracts was identified on Western immunoblots of polyacrylamide gels. It was also shown that pituitary tissue maintained in culture secretes the 20 kD form. A rat growth hormone cDNA f...

journal_title：Biochemical and biophysical research communications

authors： Howland DS,Farrington MA,Taylor WD,Hymer WC

更新日期：1987-09-15 00:00:00

abstract：:To investigate the role of myotonin-protein kinase (MT-PK) in the pathophysiology of myotonic dystrophy (DM), we developed specific antibodies against synthetic MT-PK peptides. The antibody identified a 53kDa protein in skeletal muscle and recognized decreases in the amount of the protein in both adult and congenital ...

journal_title：Biochemical and biophysical research communications

authors： Koga R,Nakao Y,Kurano Y,Tsukahara T,Nakamura A,Ishiura S,Nonaka I,Arahata K

更新日期：1994-07-15 00:00:00

abstract：:Stimulation of human T cell line Jurkat results in rapid tyrosine phosphorylation of a 35-38 kDa protein that is found in large and buoyant detergent-resistant membrane microdomains containing also glycosylphosphatidylinositol (GPI)-anchored proteins, glycolipids and Src-family protein tyrosine kinases ("GPI-microdoma...

journal_title：Biochemical and biophysical research communications

authors： Brdiĉka T,Cerný J,Horejŝí V

更新日期：1998-07-20 00:00:00

abstract：:Pluripotent human embryonic stem cells (hESCs) have the distinguishing feature of innate capacity to allow indefinite self-renewal. This attribute continues until specific constraints or restrictions, such as DNA methylation, are imposed on the genome, usually accompanied by differentiation. With the aim of utilizing ...

journal_title：Biochemical and biophysical research communications

authors： Yeo S,Jeong S,Kim J,Han JS,Han YM,Kang YK

更新日期：2007-08-03 00:00:00

abstract：:Fecal supernatant or serum containing TT virus (TTV) of genotype 1a (10(5) copies/ml) from patients with acute TTV infection was inoculated intravenously into two naive chimpanzees. Serum samples were obtained weekly and tested for TTV DNA by genotype 1-specific polymerase chain reaction. TTV DNA was detected in chimp...

journal_title：Biochemical and biophysical research communications

authors： Tawara A,Akahane Y,Takahashi M,Nishizawa T,Ishikawa T,Okamoto H

更新日期：2000-11-19 00:00:00

abstract：:Osteopontin (OPN) is involved in exacerbating various inflammatory diseases. A severe pulmonary inflammation is frequently found in lethal influenza A virus (IAV) infection. However, the function of OPN against the infection was poorly understood. Here, we demonstrate an importance of OPN on immune response and diseas...

journal_title：Biochemical and biophysical research communications

authors： Sato K,Iwai A,Nakayama Y,Morimoto J,Takada A,Maruyama M,Kida H,Uede T,Miyazaki T

更新日期：2012-01-06 00:00:00

abstract：:Using circular dichroism, fluorescence, and infrared spectroscopies, we studied the secondary structure of purified hamster PrP(C) in the presence of the mild, nonionic detergent octylglucoside. Under these native conditions, PrP(C) displayed an unexpectedly high beta-sheet component, intermediate between the values p...

journal_title：Biochemical and biophysical research communications

authors： Pergami P,Bramanti E,Ascoli GA

更新日期：1999-11-02 00:00:00