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In organello footprinting analysis of rat mitochondrial DNA: protein interaction upstream of the Ori-L.

Abstract：

:An in organello footprinting approach has been used to probe a protein-DNA interaction of a nuclear coded 25 kDa protein, previously isolated in our laboratory, that binds "in vitro" a region within the ND2 gene, located upstream of the Ori-L. Footprinting studies with the purine-modifying reagent dimethyl sulfate and the pirimidine-modifying reagent potassium permanganate were carried out in isolated mitochondria from rat liver. Dimethyl sulfate footprinting has allowed the detection of a protein-DNA interaction within the curved ND2 region with contact sites located in both the strands. Potassium permanganate footprinting allowed detection of an adjacent permanganate-reactive region. We hypothesize that the permanganate-reactive region is a single stranded DNA due to a profound helix distortion induced by a 25 kDa protein binding to the nearest region.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cingolani G,Capaccio L,D'Elia D,Gadaleta G

doi

10.1006/bbrc.1997.6203

subject

Has Abstract

pub_date

1997-02-24 00:00:00

pages

856-60

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)96203-3

journal_volume

231

pub_type

杂志文章

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