当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Cadmium interferes with the degradation of ATF5 via a post-ubiquitination step of the proteasome degradation pathway.

Cadmium interferes with the degradation of ATF5 via a post-ubiquitination step of the proteasome degradation pathway.

Abstract：

:ATF5 is a member of the CREB/ATF family of transcription factors. In the current study, using a transient transfection system to express FLAG epitope fusion proteins of ATF5, we have shown that CdCl(2) or NaAsO(3) increases the protein levels of ATF5 in cells, and that cadmium stabilizes the ATF5 protein. Proteasome inhibitors had a similar effect to cadmium on the cellular accumulation of ATF5. Proteasome inhibition led to an increase in ubiquitinated ATF5, while cadmium did not appear to reduce the extent of ATF5 ubiquitination. ATF5 contains a putative nuclear export signal within its N-terminus. We demonstrated that whereas deletion of N-terminal region resulted in a increase of ATF5 levels, this region does not appear to be involved in the ubiquitination of ATF5. These results indicate that ATF5 is targeted for degradation by the ubiquitin-proteasome pathway, and that cadmium slows the rate of ATF5 degradation via a post-ubiquitination mechanism.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Uekusa H,Namimatsu M,Hiwatashi Y,Akimoto T,Nishida T,Takahashi S,Takahashi Y

doi

10.1016/j.bbrc.2009.01.158

subject

Has Abstract

pub_date

2009-03-13 00:00:00

pages

673-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)00206-X

journal_volume

380

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Activation of glutathione peroxidase via Nrf1 mediates genistein's protection against oxidative endothelial cell injury.

    abstract：:Cellular actions of isoflavones may mediate the beneficial health effects associated with high soy consumption. We have investigated protection by genistein and daidzein against oxidative stress-induced endothelial injury. Genistein but not daidzein protected endothelial cells from damage induced by oxidative stress. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.05.197

    authors： Hernandez-Montes E,Pollard SE,Vauzour D,Jofre-Montseny L,Rota C,Rimbach G,Weinberg PD,Spencer JP

    更新日期：2006-08-04 00:00:00

  • Accumulation and specific cleavage of 5S RNA in the isthmus of laying hen oviduct. Evidence for three chicken 5S RNA.

    abstract：:RNA extracts from the isthmus of laying hen oviduct contain truncated 5S RNA molecules that were found to be shorter at their 5' terminus as compared to native 5S RNA I and II. Moreover one of the truncated species differs from 5S RNA I by the absence of the 3' end nucleotide. The truncated forms increase of about 70%...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80439-9

    authors： Keith G,Nys Y,Fix C,Heyman T

    更新日期：1986-08-14 00:00:00

  • Calcium-dependent activation of human neutrophils by a synthetic ionophore.

    abstract：:Synthetic block copolymers composed of polyoxyethylene and poly-oxypropylene have been demonstrated to possess ionophore activity selective for monovalent cations and to cause histamine release from mouse mast cells and human basophils. We now report calcium-dependent release of granule contents from human neutrophils...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92122-0

    authors： Atkinson P,Berkow RL

    更新日期：1989-08-30 00:00:00

  • Heterogeneity of insulin-like growth factor-I affinity for the insulin-like growth factor-II receptor: comparison of natural, synthetic and recombinant DNA-derived insulin-like growth factor-I.

    abstract：:Although insulin-like growth factors (IGF) I and II bind with high affinity to structurally discrete receptors, they bind with a lesser affinity to each other's receptor. We have evaluated the affinity of five different IGF-I preparations (three natural IGF-I preparations, one synthetic preparation, and one recombinan...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)90650-4

    authors： Rosenfeld RG,Conover CA,Hodges D,Lee PD,Misra P,Hintz RL,Li CH

    更新日期：1987-02-27 00:00:00

  • Development of an affinity chromatography resin for the purification of carcinogen binding proteins from mouse liver.

    abstract：:Pyrene, a structural analog of benzo[a]pyrene, is an effective competing ligand for high affinity carcinogen binding proteins in mouse liver. A pyrene-derivatized Sepharose gel was prepared for affinity chromatography purification of these proteins, and adsorbs all detectable [3H]B[a]P-binding activity from hepatic cy...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91416-0

    authors： Collins S,Altman JD,Marletta MA

    更新日期：1985-05-31 00:00:00

  • Expression and characterization of recombinant kurtoxin, an inhibitor of T-type voltage-gated calcium channels.

    abstract：:Kurtoxin, a 63-amino acid peptide stabilized by four disulfide bonds, is the first reported peptide inhibitor of T-type voltage-gated calcium channels. Although T-type calcium channels have been implicated in a number of disease states, including epilepsy, chronic pain, hypertension and cancer, the lack of selective i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.11.003

    authors： Lee CW,Eu YJ,Min HJ,Cho EM,Lee JH,Kim HH,Nah SY,Swartz KJ,Kim JI

    更新日期：2011-12-16 00:00:00

  • Effect of Fe2+ -induced lipid peroxidation upon microsomal steroidogenic enzyme activities of porcine adrenal cortex.

    abstract：:When porcine adrenocortical microsomes were treated with Fe2+, enhanced production of malondialdehyde was observed as a result of membrane lipid peroxidation. By treatment of the microsomes with Fe2+, the activity of delta 5-3 beta-hydroxysteroid dehydrogenase coupled with delta 5-delta 4 isomerase, concentration of c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90096-8

    authors： Imataka H,Suzuki K,Tamaoki B

    更新日期：1985-04-30 00:00:00

  • MicroRNA-613 represses prostate cancer cell proliferation and invasion through targeting Frizzled7.

    abstract：:A growing number of studies have indicated that microRNAs (miRNAs) are critical regulators of carcinogenesis and cancer progression and may serve as potential therapeutic tools for cancer therapy. Frizzled7 (Fzd7), the most important receptor of the Wnt signaling pathway, is extensively involved in cancer development ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.12.054

    authors： Ren W,Li C,Duan W,Du S,Yang F,Zhou J,Xing J

    更新日期：2016-01-15 00:00:00

  • Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis.

    abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and often fatal pulmonary disorder, and its pathology is characterized by parenchymal fibrosis. To investigate the characteristics of fibroblasts in IPF, we obtained eight fibroblast cell lines from lungs with IPF and eight lines from normal lungs. We foun...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.128

    authors： Shoda H,Yokoyama A,Nishino R,Nakashima T,Ishikawa N,Haruta Y,Hattori N,Naka T,Kohno N

    更新日期：2007-02-23 00:00:00

  • An amino acid exchange in exon I of the human lecithin: cholesterol acyltransferase (LCAT) gene is associated with fish eye disease.

    abstract：:The exons of the lecithin:cholesterol acyltransferase (LCAT) gene in DNA samples from two of the original Swedish Fish Eye Disease patients have been amplified by polymerase chain reactions and sequenced by the dideoxy method. The two patients apparently were unrelated. In both patients a mutation in codon 10 of the f...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91772-i

    authors： Skretting G,Prydz H

    更新日期：1992-01-31 00:00:00

  • X-linked adrenoleukodystrophy phenotype is independent of ABCD2 genotype.

    abstract：:Strikingly variable clinical phenotypes can be found in X-linked adrenoleukodystrophy (X-ALD) even with the same ABCD1 mutation. ABCD2 is the closest homolog to ABCD1. Since ABCD2 overexpression complements the loss of ABCD1 in vivo and in vitro, we have investigated the possible role of the ABCD2 gene locus as determ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.09.092

    authors： Maier EM,Mayerhofer PU,Asheuer M,Köhler W,Rothe M,Muntau AC,Roscher AA,Holzinger A,Aubourg P,Berger J

    更新日期：2008-12-05 00:00:00

  • In silico assessment of interaction of sea anemone toxin APETx2 and acid sensing ion channel 3.

    abstract：:Acid sensing ion channels (ASICs) are proton-gated cation channels that are expressed throughout the nervous system and have been implicated in mediating sensory perception of noxious stimuli. Amongst the six ASIC isoforms, ASIC1a, 1b, 2a and 3 form proton-gated homomers, which differ in their activation and inactivat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.05.130

    authors： Rahman T,Smith ES

    更新日期：2014-07-18 00:00:00

  • Rat atrial natriuretic factor: isolation, structure and biological activities of four major peptides.

    abstract：:Four peptides possessing both natriuretic activity and smooth muscle relaxant activity were isolated from rat atrium and their amino acid sequences determined. The four peptides designated ANF-I, ANF-II, ANF-III and ANF-IV containing 35, 31, 30 and 25 amino acid residues, respectively, were obtained in a molar ratio o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90250-x

    authors： Misono KS,Grammer RT,Fukumi H,Inagami T

    更新日期：1984-09-17 00:00:00

  • Flap loop of GluD2 binds to Cbln1 and induces presynaptic differentiation.

    abstract：:Glutamate receptor delta2 (GluD2) is selectively expressed on the postsynaptic spines at parallel-fiber (PF)-Purkinje neuron (PN) synapses. GluD2 knockout mice show a reduced number of PF-PN synapses, suggesting that GluD2 is involved in synapse formation. Recent studies revealed that GluD2 induces presynaptic differe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.06.114

    authors： Kuroyanagi T,Hirano T

    更新日期：2010-07-30 00:00:00

  • Ghrelin alters neurite outgrowth and electrophysiological properties of mouse ventrolateral arcuate tyrosine hydroxylase neurons in culture.

    abstract：:While the appetite-stimulating hormone ghrelin can act to acutely modulate electrical activity of neurons in the appetite regulating network, it also has a role in regulating neuronal outgrowth, synaptic connectivity and intrinsic electrophysiological properties. In this study, we investigated whether ghrelin may caus...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.09.069

    authors： Huang S,Lee SA,Oswald KE,Fry M

    更新日期：2015-10-30 00:00:00

  • Glucose and insulin are needed for optimal defensin expression in human cell lines.

    abstract：:Many infections are associated with diabetes, as the ability of the body to fight pathogens is impaired. Recently, low levels of defensins have been found in diabetic rodents. However, whether hyperglycemia and/or insulin deficiency/insensitivity is the reason for the reduced defensin levels is still unknown. To study...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.12.158

    authors： Barnea M,Madar Z,Froy O

    更新日期：2008-03-07 00:00:00

  • Effects of folic acid deficiency and MTHFRC677T polymorphisms on cytotoxicity in human peripheral blood lymphocytes.

    abstract：:Apoptosis (APO) and necrosis (NEC) are two different types of cell death occurring in response to cellular stress factors. Cells with DNA damage may undergo APO or NEC. Folate is an essential micronutrient associated with DNA synthesis, repair and methylation. Methylenetetrahydrofolate reductase (MTHFR) regulates intr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.12.130

    authors： Wu X,Liang Z,Zou T,Wang X

    更新日期：2009-02-13 00:00:00

  • Impact of methionine oxidation on calmodulin structural dynamics.

    abstract：:We have used electron paramagnetic resonance (EPR) to examine the structural impact of oxidizing specific methionine (M) side chains in calmodulin (CaM). It has been shown that oxidation of either M109 or M124 in CaM diminishes CaM regulation of the muscle calcium release channel, the ryanodine receptor (RyR), and tha...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.11.091

    authors： McCarthy MR,Thompson AR,Nitu F,Moen RJ,Olenek MJ,Klein JC,Thomas DD

    更新日期：2015-01-09 00:00:00

  • Phorbol ester activation of phospholipase D in human monocytes but not peripheral blood lymphocytes.

    abstract：:Previous reports have shown that 12-0-tetradecanoylphorbol-13-acetate can activate phospholipase D in human peripheral blood mononuclear cells as measured by an enzyme-catalyzed transphosphatidylation reaction (phosphatidylethanol formation). In the present study, the mononuclear cells were fractionated by two procedu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92379-6

    authors： Kinsky SC,Loader JE,Benedict SH

    更新日期：1989-07-31 00:00:00

  • MicroRNA-139 suppresses proliferation in luminal type breast cancer cells by targeting Topoisomerase II alpha.

    abstract：:The classification of molecular subtypes of breast cancer improves the prognostic accuracy and therapeutic benefits in clinic. However, because of the complexity of breast cancer, more biomarkers and functional molecules need to be explored. Here, analyzing the data in a huge cohort of breast cancer patients, we found...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.06.061

    authors： Hua W,Sa KD,Zhang X,Jia LT,Zhao J,Yang AG,Zhang R,Fan J,Bian K

    更新日期：2015-08-07 00:00:00

  • Maternally-derived antibody to fibroblast growth factor-23 reduced dietary phosphate requirements in growing chicks.

    abstract：:Phosphate in manure of monogastric animals pollutes the environment if improperly applied to soil. Strategies that reduce phosphate inputs into animal production systems reduce environmental pollution. Using a novel vaccine to fibroblast growth factor-23 (FGF-23), we induced neutralizing antibodies that reduced the ph...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.03.063

    authors： Bobeck EA,Burgess KS,Jarmes TR,Piccione ML,Cook ME

    更新日期：2012-04-13 00:00:00

  • Potent inhibition of CTLA-4 expression by an anti-CTLA-4 ribozyme.

    abstract：:Blockading the negative-regulatory CTLA-4 receptor has emerged as a powerful strategy with clinical potential to enhance T-cell responses. Some experimental tumors, for example, are rejected when anti-CTLA-4 antibodies are administered in vivo. The concise target cells and downstream events, however, remain to be defi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8889

    authors： Cepero E,Hnatyszyn HJ,Kraus G,Lichtenheld MG

    更新日期：1998-06-29 00:00:00

  • Dystrophin-related protein in the fetal and denervated skeletal muscles of normal and mdx mice.

    abstract：:The amino acid sequence of the polyclonal antibodies we developed against the carboxyl terminus of the dystrophin-related protein, the putative gene product of B3 cDNA, had no homologous sequence to the dystrophin molecule except for two amino acids located at its ends for immunization. By immunohistochemical examinat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81320-8

    authors： Takemitsu M,Ishiura S,Koga R,Kamakura K,Arahata K,Nonaka I,Sugita H

    更新日期：1991-11-14 00:00:00

  • Polyamine depletion inhibits the differentiation of L6 myoblast cells.

    abstract：:Exposure to alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, inhibited the insulin induced differentiation of L6 myoblast cells. Differentiation was assessed by measuring creatine kinase activity and by determining the percentage of nuclei in myotubes. The levels of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)90651-4

    authors： Erwin BG,Ewton DZ,Florini JR,Pegg AE

    更新日期：1983-08-12 00:00:00

  • Enhanced expression of Silencer of death domains (SODD/BAG-4) in pancreatic cancer.

    abstract：:Pancreatic cancers are resistant to TNF-alpha-mediated apoptosis. Silencer of death domains (SODD) binds to TNF-alpha receptor TNFR-1, and prevents spontaneous self-association of death domains and inappropriate receptor signaling. In addition, overexpression of SODD suppresses TNF-alpha-induced cell death. In this re...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2610

    authors： Ozawa F,Friess H,Zimmermann A,Kleeff J,Büchler MW

    更新日期：2000-05-10 00:00:00

  • NF-κB subunit RELA suppression of mucosa-associated lymphoid tissue lymphoma translocation protein 1 expression in oral carcinoma cells.

    abstract：:Loss of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) expression closely associates with increased aggressive behaviors of oral carcinoma cells. It emphasizes that a mechanism to suppress the expression is an important subject for understanding carcinoma progression pathway. However, nothi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2021.01.025

    authors： Nozawa T,Mihara-Tomiyama N,Chiba T,Imai K

    更新日期：2021-01-19 00:00:00

  • Sensitization of TNF-induced cytotoxicity in lung cancer cells by concurrent suppression of the NF-kappaB and Akt pathways.

    abstract：:Blockage of either nuclear factor-kappaB (NF-kappaB) or Akt sensitizes cancer cells to TNF-induced apoptosis. In this study, we investigated the undetermined effect of concurrent blockage of these two survival pathways on TNF-induced cytotoxicity in lung cancer cells. The results show that Akt contributes to TNF-induc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.02.030

    authors： Wang X,Chen W,Lin Y

    更新日期：2007-04-13 00:00:00

  • Silencing MR-1 attenuates inflammatory damage in mice heart induced by AngII.

    abstract：:Myofibrillogenesis regulator-1(MR-1) can aggravate cardiac hypertrophy induced by angiotensin(Ang) II in mice through activation of NF-kappaB signaling pathway, and nuclear transcription factor (NF)-kappaB and activator protein-1(AP-1) regulate inflammatory and immune responses by increasing the expression of specific...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.12.130

    authors： Dai W,Chen H,Jiang J,Kong W,Wang Y

    更新日期：2010-01-15 00:00:00

  • An emerging role of deubiquitinating enzyme cylindromatosis (CYLD) in the tubulointerstitial inflammation of IgA nephropathy.

    abstract：:Immunoglobulin A (IgA) nephropathy is an important cause of end-stage kidney disease (ESKD). Tubulointerstitial inflammation and subsequent fibrosis appear to be a major contributor of the disease progression to ESKD; however, the underlying mechanism is poorly understood. Herein, we report that a unique feature of CY...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.09.119

    authors： Cui TG,Ichikawa T,Yang M,Dong X,Li J,Cui T

    更新日期：2009-12-11 00:00:00

  • FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation.

    abstract：:Intricate cross-talks exist among multiple post-translational modifications that play critical roles in various cellular events, such as the control of gene expression and regulation of protein function. Here, the cross-talk between O-GlcNAcylation and ubiquitination was investigated in HEK293T cells. By PCR array, 84...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.07.091

    authors： Feng Z,Hui Y,Ling L,Xiaoyan L,Yuqiu W,Peng W,Lianwen Z

    更新日期：2013-08-23 00:00:00