Regulation of progastricsin mRNA levels in sea bass (Dicentrarchus labrax) in response to fluctuations in food availability.

abstract：:The RNA binding proteins (RBPs) have multiple roles in human cancer. However, their molecular target and function have not been clearly identified. Our genomic analysis derived from patients reveals that NONO is a potential oncogenic gene in lung cancer. NONO is highly expressed in lung cancer tissues compared with no...

journal_title：Biochemical and biophysical research communications

authors： Kim SJ,Ju JS,Park SS,Suh YA,Yoo HJ,Choi EK,Seong-Yun Jeong,Shin Y,Park YY

更新日期：2020-07-23 00:00:00

abstract：:The ATP-sensitive potassium channel of insulin-secreting pancreatic beta-cells is a complex of Kir6.2, a member of the inwardly rectifying potassium channel superfamily, and the sulfonylurea receptor. We have isolated cDNA clones encoding rat Kir6.2. Co-expression of rat Kir6.2 and sulfonylurea receptor in human embry...

journal_title：Biochemical and biophysical research communications

authors： Tokuyama Y,Fan Z,Furuta H,Makielski JC,Polonsky KS,Bell GI,Yano H

更新日期：1996-03-27 00:00:00

abstract：:In this study, an endogenous factor(s) involved in the suppression of the induction of CYP1A1 was studied. Analyzing the sequences, we found that the sequence of xenobiotic responsive element (XRE) in the upstream region of the human CYP1A1 gene was overlapped with that of the upstream stimulatory factor 1 (USF1)-bind...

journal_title：Biochemical and biophysical research communications

authors： Takahashi Y,Nakayama K,Itoh S,Kamataki T

更新日期：1997-11-17 00:00:00

abstract：:RING finger (C3HC4-type zinc finger) is a variant zinc finger motif present in a large family of functionally distinct proteins. We describe the cloning and characterization of a novel human transcript RNF38 encoding a new member of the RING finger protein family. The complete mRNA consists of about 6.8 kb widely expr...

journal_title：Biochemical and biophysical research communications

authors： Eisenberg I,Hochner H,Levi T,Yelin R,Kahan T,Mitrani-Rosenbaum S

更新日期：2002-06-28 00:00:00

abstract：:The vanilloid receptor type 1 (VR1) is a novel membrane receptor activated by heat or chemical ligands conveying information about chemosensitive and thermosensitive pain. We have overexpressed and purified wild type VR1 (wtVR1) as well as several mutant forms using the yeast strain Saccharomyces cerevisiae with the g...

journal_title：Biochemical and biophysical research communications

authors： Moiseenkova VY,Hellmich HL,Christensen BN

更新日期：2003-10-10 00:00:00

abstract：:Platelet-derived growth factor (PDGF)-BB elicits a migratory response including reorganization of the actin cytoskeleton in different cell types. Here we have investigated the effects of PDGF-BB stimulation on beta(1) integrin containing focal adhesions in human diploid fibroblasts adhered to collagen type I. Stimulat...

journal_title：Biochemical and biophysical research communications

authors： Ahlén K,Ring P,Tomasini-Johansson B,Holmqvist K,Magnusson KE,Rubin K

更新日期：2004-01-30 00:00:00

abstract：:Our results show that in the intact normal animal cell mitochondrial ATP is directly connected to nuclear PARP-1 by way of a specific adenylate kinase enzymatic path. This mechanism is demonstrated in two models: (a) by its inhibition with a specific inhibitor of adenylate kinase, and (b) by disruption of ATP synthesi...

journal_title：Biochemical and biophysical research communications

authors： Kun E,Kirsten E,Hakam A,Bauer PI,Mendeleyev J

更新日期：2008-02-08 00:00:00

abstract：:Fasting triggers a complex array of adaptive metabolic and hormonal responses including an augmentation in the capacity for mitochondrial fatty acid (FA) oxidation in skeletal muscle. This study hypothesized that this adaptive response is mediated by increased mRNA of key genes central to the regulation of fat oxidati...

journal_title：Biochemical and biophysical research communications

authors： Tunstall RJ,Mehan KA,Hargreaves M,Spriet LL,Cameron-Smith D

更新日期：2002-06-07 00:00:00

abstract：:A secondary structure has been predicted for the hemorrhagic metalloproteases using a method developed in Zurich that extracts structural information from patterns of conservation and variation in homologous protein sequences. This prediction tests the limits of the method when applied to a small number of homologous ...

journal_title：Biochemical and biophysical research communications

authors： Gerloff DL,Jenny TF,Knecht LJ,Benner SA

更新日期：1993-07-15 00:00:00

abstract：:A monoclonal antibody (MaB) against mouse sarcoma DNA polymerase alpha was isolated from the culture medium of an IgG-secreting hybridoma. The MaB demonstrated reactivity against two murine DNA polymerase alpha preparations and a calf thymus DNA polymerase alpha. Murine sarcoma polymerase was activated in vitro by pho...

journal_title：Biochemical and biophysical research communications

authors： Sylvia VL,Norman JO,Curtin GM,Busbee DL

更新日期：1986-11-26 00:00:00

abstract：:We have previously identified the region containing transcriptional enhancer in mouse immunoglobulin heavy chain (IgH) gene as an initiation region of DNA replication. The octamer sequence therein has been found to be essential for initiation of DNA replication as well as for transcription. Octamer-binding protein fam...

journal_title：Biochemical and biophysical research communications

authors： Ogawa N,Ariga H,Iguchi-Ariga SM

更新日期：1994-05-16 00:00:00

abstract：:The transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is regulated by oxygen availability as well as various inflammatory mediators, including tumor necrosis factor alpha (TNFalpha). Early work suggested that the phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling...

journal_title：Biochemical and biophysical research communications

authors： Kuo HP,Lee DF,Xia W,Wei Y,Hung MC

更新日期：2009-11-27 00:00:00

abstract：:This study aimed to investigate possible feedback mechanisms in the control of collagenase (matrix metalloproteinase-1) and tissue inhibitor of metalloproteinases (TIMP-1). Procollagenase, active collagenase, TIMP-1 and collagenase-TIMP complex were applied to human skin and synovial fibroblasts for 48 hours, the cell...

journal_title：Biochemical and biophysical research communications

authors： Clark IM,Powell LK,Cawston TE

更新日期：1994-09-15 00:00:00

abstract：:The murine 3T3-L1 preadipocyte cell line is well characterized for its capacity to undergo differentiation into adipocytes under appropriate hormonal stimulation. p107, a member of the retinoblastoma tumor suppressor gene family has been shown to be dramatically upregulated during the early requisite clonal expansion ...

journal_title：Biochemical and biophysical research communications

authors： May JS,Prince AM,Lyle RE,McGehee RE Jr

更新日期：2001-05-18 00:00:00

abstract：:The rat hemopexin (Hx) gene was isolated and studies of its transcriptional regulation initiated. For analysis by a transient expression assay, the sequence between -2400 and +21 and sequential 5' truncates were linked to the chloramphenicol acetyltransferase (CAT) gene. HepG2 cells transfected with these CAT construc...

journal_title：Biochemical and biophysical research communications

authors： Nagae Y,Muller-Eberhard U

更新日期：1992-05-29 00:00:00

abstract：:Groucho is a protein implicated in Notch signaling and involved in segmentation and neural development in Drosophila. Groucho forms transcription complexes with the basic helix-loop-helix proteins encoded by the hairy/Enhancer of split ("hairy-like") gene family. These interactions are mediated by the carboxyl-termina...

journal_title：Biochemical and biophysical research communications

authors： Grbavec D,Stifani S

更新日期：1996-06-25 00:00:00

abstract：:ADAMTS13 cleaves multimeric von Willebrand factor (VWF) to regulate VWF-mediated thrombus formation. To search ADAMTS13 peptide sequences binding to VWF, a lambda-phage library expressing various peptides of ADAMTS13 on the surface was screened using VWF either immobilized or in solution under static condition. By the...

journal_title：Biochemical and biophysical research communications

authors： Moriki T,Maruyama IN,Igari A,Ikeda Y,Murata M

更新日期：2010-01-01 00:00:00

abstract：:Removal of parts of a known calmodulin binding site at the C-terminus of HIV-1 envelope glycoprotein, gp160, can result in diminished infectivity. We investigated whether expression of full length gp160 would result in changes in intracellular calmodulin compared to expression of gp160 truncated to remove both known c...

journal_title：Biochemical and biophysical research communications

authors： Radding W,Pan ZQ,Hunter E,Johnston P,Williams JP,McDonald JM

更新日期：1996-01-05 00:00:00

abstract：:Autophagy has been associated with a variety of diseases especially aging. Human dermal fibroblasts (HDFs) can internalize and then degrade elastin, collagen and advanced glycation end products (AGEs) in lysosomes, which plays prominent roles in extracellular matrix homeostasis and AGEs removal in the dermis. Although...

journal_title：Biochemical and biophysical research communications

authors： Huang Y,Li Y,Qu Y,Zheng Y,Ouyang M,Zhang Y,Lai W,Xu Q

更新日期：2019-10-22 00:00:00

abstract：:The 32/20-kDa two-chain form of protective protein/cathepsin A (CathA) secreted by human platelets was thermostable in the aggregation supernatant at acidic pH, but was denatured at neutral pH. Leupeptin partly protected the CathA against denaturation, which was not observed in the supernatant after depletion of the c...

journal_title：Biochemical and biophysical research communications

authors： Itoh K,Naganawa Y,Kamei S,Shimmoto M,Sakuraba H

更新日期：1998-12-18 00:00:00

abstract：:Plasma membrane receptors can undergo translocation in the plane of plasma membrane after binding of polyvalent ligands. Ligand/receptor clusters, named patches, can collect into a polar cap, presumably due to their association with the submembrane actin-based cytoskeleton. We found that the assembly of Fcgamma recept...

journal_title：Biochemical and biophysical research communications

authors： Kwiatkowska K,Sobota A

更新日期：1999-06-07 00:00:00

abstract：:Excessive oxidative stress induces significant injury and cytotoxicity to neuronal cells. The current study tested expression and the potential function of the circular RNA PRKCI (circPRKCI) in oxidative stress-injured neuronal cells. In cultured SH-SY5Y neuronal cells, hydrogen peroxide (H2O2) downregulated circPRKCI...

journal_title：Biochemical and biophysical research communications

authors： Cheng Q,Cao X,Xue L,Xia L,Xu Y

更新日期：2019-06-25 00:00:00

abstract：:Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human and mouse embryonic stem cells express Kit transcripts. Stem cell factor exists as both a soluble and a membrane-bound glycoprotein while Kit...

journal_title：Biochemical and biophysical research communications

authors： Roskoski R Jr

更新日期：2005-12-23 00:00:00

abstract：:Lysenin, a hemolytic protein derived from the body fluid of earthworm, was incorporated into artificial bilayer membranes. Upon insertion, it formed a voltage-dependent large conductance channel in asolectin bilayers in a sphingomyelin-dependent manner. The channel had low ion-selectivity. Single-channel conductance w...

journal_title：Biochemical and biophysical research communications

authors： Ide T,Aoki T,Takeuchi Y,Yanagida T

更新日期：2006-07-21 00:00:00

abstract：:The catalytic and immunological properties of acid phosphatases (EC 3.1.3.2.) in different tissues were studied. It was demonstrated that high uptake forms of lysosomal enzymes like beta-galactosidase isolated from human platelets and bovine testis are mature enzymes, which have not lost their mannose-6phosphate marke...

journal_title：Biochemical and biophysical research communications

authors： Hu P,Parenti G,Keulemans J,Hoogeveen AT

更新日期：1990-03-16 00:00:00

abstract：:Measurement and validation of microarray gene signatures in routine clinical samples is problematic and a rate limiting step in translational research. In order to facilitate measurement of microarray identified gene signatures in routine clinical tissue a novel method combining quantum dot based oligonucleotide in si...

journal_title：Biochemical and biophysical research communications

authors： Tholouli E,MacDermott S,Hoyland J,Yin JL,Byers R

更新日期：2012-08-24 00:00:00

abstract：:Various dehydrogenation polymers (the so-called synthetic lignins) were synthesized from four different phenylpropenoids by endwise and bulk polymerizations and investigated for their anti-influenza virus activity. All of these materials suppressed the plaque formation of influenza virus infecting MDCK cells and the R...

journal_title：Biochemical and biophysical research communications

authors： Sakagami H,Nagata K,Ishihama A,Oh-hara T,Kawazoe Y

更新日期：1990-11-15 00:00:00

abstract：:Using red cells as an experimental model, we previously showed that a limited degradation of certain membrane proteins by calpain (Ca2+-activated thiol protease) was a necessary prerequisite for cell fusion and that fusibility depended on the ratio of calpain to its endogenous inhibitor calpastatin. Here we show that ...

journal_title：Biochemical and biophysical research communications

authors： Barnoy S,Glasner T,Kosower NS

更新日期：1996-03-27 00:00:00

abstract：:cDNA clones encoding a precursor of the alpha-subunit of the mitochondrial ATP synthase complex have been isolated from a bovine liver cDNA library using the alpha-subunit gene from Saccharomyces cerevisiae as a probe. Analyses of the nucleotide sequence of these cDNA clones reveal that the bovine liver ATP synthase a...

journal_title：Biochemical and biophysical research communications

authors： Breen GA

更新日期：1988-04-15 00:00:00

abstract：:Oxysterols are 27-carbon oxidation products of cholesterol metabolism. Oxysterols possess several biological actions, including the promotion of cell death. Here, we examined the ability of several oxysterols to induce short-term death in cancerous (human breast cancer and mouse skin melanoma cells) and non-cancerous ...

journal_title：Biochemical and biophysical research communications

authors： Levy D,Correa de Melo T,Ohira BY,Fidelis ML,Ruiz JLM,Rodrigues A,Bydlowski SP

更新日期：2018-11-10 00:00:00