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(-)-Epigallocatechin gallate inhibition of osteoclastic differentiation via NF-kappaB.

Abstract：

:People who regularly drink tea have been found to have a higher bone mineral density (BMD) and to be at less risk of hip fractures than those who do not drink it. Green tea catechins such as (-)-epigallocatechin gallate (EGCG) have been reported to increase osteogenic functioning in mesenchymal stem cells. However, its effect on osteoclastogenesis remains unclear. In this study, we investigated the effect of EGCG on RANKL-activation osteoclastogenesis and NF-kappaB in RAW 264.7, a murine preosteoclast cell line. EGCG (10-100 microM) significantly suppressed the RANKL-induced differentiation of osteoclasts and the formation of pits in murine RAW 264.7 cells and bone marrow macrophages (BMMs). EGCG appeared to target osteoclastic differentiation at an early stage but had no cytotoxic effect on osteoclast precursors. In addition, it significantly inhibited RANKL-induced NF-kappaB transcriptional activity and nuclear translocation. We conclude that EGCG inhibits osteoclastogenesis through its activation of NF-kappaB.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lin RW,Chen CH,Wang YH,Ho ML,Hung SH,Chen IS,Wang GJ

doi

10.1016/j.bbrc.2009.01.007

subject

Has Abstract

pub_date

2009-02-20 00:00:00

pages

1033-7

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)00019-9

journal_volume

379

pub_type

杂志文章

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